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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATPase, Ca++ transporting, plasma membrane 2

PMCA2
Top mentioned proteins: ATPase, PMCA, PMCA1, PMCA4, PMCA3
Papers on PMCA2
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
New
Wysolmerski et al., New Haven, United States. In Proc Natl Acad Sci U S A, Feb 2016
In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium.
Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition.
New
Zylinska et al., Łódź, Poland. In Mol Cell Biochem, Sep 2015
From four PMCA isoforms, PMCA2, and PMCA3 respond to a rapid removal of Ca(2+) and are expressed predominantly in excitable cells.
Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy.
Ohlendieck et al., Ireland. In Clin Proteomics, 2014
Decreased proteins were identified as the nervous system-specific proteins syntaxin-1B and syntaxin-binding protein 1, as well as the plasma membrane Ca(2+)-transporting ATPase PMCA2 that is mostly found in the brain cortex.
Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population.
Zhang et al., Suzhou, China. In Biomed Environ Sci, 2014
In the present study, eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23), rs1695 (GSTP1), rs137852540 (GJB2), rs2289274 (PMCA2), rs4880 (SOD2), rs7943316, and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers.
Disrupted calcium homeostasis is involved in elevated zinc ion-induced photoreceptor cell death.
Bi et al., Jinan, China. In Arch Biochem Biophys, 2014
In the present study, using zinc chloride (ZnCl2) as a stressor, we investigated the effect of exogenous Zn(2+) in regulating murine photoreceptor cell viability, reactive oxygen species (ROS), cell cycle distribution and calcium homeostasis as well as plasma membrane calcium ATPase (PMCA) isoforms (PMCA1 and PMCA2, i.e., ATP2B1, ATP2B2) expression.
Changes in cochlear PMCA2 expression correlate with the maturation of auditory sensitivity.
Tempel et al., Seattle, United States. In J Assoc Res Otolaryngol, 2014
The plasma membrane Ca(2+) ATPase 2 (PMCA2) is necessary for auditory transduction and serves as the primary Ca(2+) extrusion mechanism in auditory stereocilia bundles.
Plasma membrane Ca2+-ATPase isoforms composition regulates cellular pH homeostasis in differentiating PC12 cells in a manner dependent on cytosolic Ca2+ elevations.
Zylinska et al., Łódź, Poland. In Plos One, 2013
PMCA exists in four isoforms (PMCA1-4) but only PMCA2 and PMCA3, due to their unique localization and features, perform more specialized function.
Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice.
Hernandez et al., Madison, United States. In Plos One, 2013
Here we demonstrate that serotonin deficiency decreases the expression and disrupts the normal localization of calcium transporters located in the apical (PMCA2) and basolateral (CaSR, ORAI-1) membranes of the lactating mammary gland.
Silencing of plasma membrane Ca2+-ATPase isoforms 2 and 3 impairs energy metabolism in differentiating PC12 cells.
Zylinska et al., Łódź, Poland. In Biomed Res Int, 2013
From four PMCA isoforms, the fastest PMCA2 and PMCA3 are expressed predominantly in excitable cells.
The plasma membrane calcium pump in health and disease.
Review
Carafoli et al., Padova, Italy. In Febs J, 2013
Genetic defects of PMCA function produce disease phenotypes: the best characterized is a form of deafness in mice and in humans linked to PMCA2 mutations.
Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in β-cell function and diabetes.
Review
Pachera et al., Brussels, Belgium. In Adv Exp Med Biol, 2012
Gain of function studies show that overexpression of NCX1 or PMCA2 leads to endoplasmic reticulum (ER) Ca(2+) depletion with subsequent ER stress, decrease in β-cell proliferation and β-cell death by apoptosis.
Hair cells, plasma membrane Ca²⁺ ATPase and deafness.
Review
Carafoli et al., Padova, Italy. In Int J Biochem Cell Biol, 2012
Cadherin 23 and the plasma membrane calcium ATPase isoform 2 (PMCA2) are defective in human and murine cases of deafness.
The plasma membrane calcium pump in the hearing process: physiology and pathology.
Review
Carafoli, Padova, Italy. In Sci China Life Sci, 2011
Two (PMCA2 and PMCA4) have tissue restricted distribution.
Ca2+ homeostasis defects and hereditary hearing loss.
Review
Mammano, Padova, Italy. In Biofactors, 2011
Another district where Ca(2+) signaling alterations link to hearing loss is hair cell apex, where ablation or missense mutations of the PMCA2 Ca(2+) -pump of the stereocilia cause deafness and loss of balance.
Modification of human hearing loss by plasma-membrane calcium pump PMCA2.
Impact
Griffith et al., Rockville, United States. In N Engl J Med, 2005
Genetic evaluation revealed that a homozygous mutation in CDH23 (which encodes cadherin 23) caused the hearing loss in all five siblings and that a heterozygous, hypofunctional variant (V586M) in plasma-membrane calcium pump PMCA2, which is encoded by ATP2B2, was associated with increased loss in the three severely affected siblings.
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