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ATPase, Ca++ transporting, plasma membrane 1

PMCA1, ATP2B1, plasma membrane calcium-ATPase
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, PMCA, PMCA4, PMCA2, PMCA3
Papers on PMCA1
Genetic loci associated with nonobstructive coronary artery disease in Caucasian women.
Cooper-DeHoff et al., Gainesville, United States. In Physiol Genomics, Jan 2016
However, SNP rs2301753 on chromosome 6 in RNF39 was associated with reduced likelihood of nonobstructive CAD [odds ratio (OR) 0.42 and 95% confidence interval (CI) of 0.29 to 0.68], at a nominal level of P = 5.6 × 10(-6), while SNP rs12818945 in the ATP2B1 locus on chromosome 12 was associated with increased odds for nonobstructive CAD (OR 2.38 and 95% CI of 1.63 to 3.45) and nominal P = 5.8 × 10(-6).
Multifaceted plasma membrane Ca(2+) pumps: From structure to intracellular Ca(2+) handling and cancer.
Enyedi et al., Budapest, Hungary. In Biochim Biophys Acta, Jan 2016
In mammals four genes (PMCA1-4) are expressed, and alternative RNA splicing generates more than twenty variants.
Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.
Kumar et al., Rochester, United States. In Biochem Biophys Res Commun, Dec 2015
The physiological importance of the intestinal plasma membrane calcium pump, isoform 1, (Pmca1, Atp2b1), in calcium absorption and homeostasis has not been previously demonstrated in vivo.
Calcium transport in bovine rumen epithelium as affected by luminal Ca concentrations and Ca sources.
Breves et al., Hannover, Germany. In Physiol Rep, Nov 2015
Standard RT-PCR method was used to characterize TRPV6 and PMCA1 as potential contributors to transepithelial active Ca transport.
Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes.
Liang et al., Milwaukee, United States. In Hypertension, Oct 2015
The result indicated significant suppression of the abundance of mRNA encoded by ADM by endogenous miR-181a-5p, ATP2B1 by the miR-27 family, FURIN by miR-125a-5p, FGF5 by the let-7 family, GOSR2 by miR-27a-3p, JAG1 by miR-21-5p, SH2B3 by miR-30a-5p, miR-98, miR-181a-5p, and the miR-125 family, TBX3 by the miR-92 family, ADRA1B by miR-22-3p, ADRA2A by miR-30a-5p and miR-30e-5p, ADRA2B by miR-30e-5p, ADRB1 by the let-7 family and miR-98, EDNRB by the miR-92 family, and NOX4 by the miR-92 family, miR-100-5p, and miR-99b-5p (n=3-9; P<0.05 versus scrambled anti-miR).
Arterial α2-Na+ pump expression influences blood pressure: lessons from novel, genetically engineered smooth muscle-specific α2 mice.
Blaustein et al., Baltimore, United States. In Am J Physiol Heart Circ Physiol, Sep 2015
Several arterial Ca(2+) transporters, including Na(+)/Ca(2+) exchanger 1 (NCX1) and sarcoplasmic reticulum and plasma membrane Ca(2+) pumps [sarco(endo)plasmic reticulum Ca(2+)-ATPase 2 (SERCA2) and plasma membrane Ca(2+)-ATPase 1 (PMCA1)], were also reduced (>50%).
Relevance of the plasma membrane calcium-ATPase in the homeostasis of calcium in the fetal liver.
Mas-Oliva et al., Mexico. In Organogenesis, 2013
During the early stages of development, the embryo depends on the placenta as provider of oxygen and calcium, among other essential compounds.
ATP2B1 and blood pressure: from associations to pathophysiology.
Umemura et al., Yokohama, Japan. In Curr Opin Nephrol Hypertens, 2013
PURPOSE OF REVIEW: Recent genome-wide association studies (GWAS) have revealed that the ATP2B1 gene is associated with hypertension not only in people of European origin, but also in Japanese, Chinese, and Koreans.
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
Gu et al., Beijing, China. In Nat Genet, 2012
These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1.
Hunting for genes for hypertension: the Millennium Genome Project for Hypertension.
Millennium Genome Project for Hypertension et al., Japan. In Hypertens Res, 2012
These multilateral approaches identified ATP2B1 as a gene responsible for hypertension in not only Japanese but also Caucasians.
Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians: a meta-analysis involving 15 909 cases and 18 529 controls.
Wang et al., Jinan, China. In Blood Press, 2012
Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians.
Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation.
Umemura et al., Yokohama, Japan. In Hypertension, 2012
ATP2B1 plays important roles in the regulation of blood pressure through alteration of calcium handling and vasoconstriction in vascular smooth muscle cells.
STIM1 is required for attenuation of PMCA-mediated Ca2+ clearance during T-cell activation.
Soboloff et al., Philadelphia, United States. In Embo J, 2012
The authors provide data revealing both functional and physical links between the activation of stromal interacting molecule 1 (STIM1) and PMCA-mediated Ca(2+) clearance.
Trafficking of presynaptic PMCA signaling complexes in mouse photoreceptors requires Cav1.4 α1 subunits.
Križaj et al., Salt Lake City, United States. In Adv Exp Med Biol, 2011
Cav1.4alpha1 is required for proper targeting of the presynaptic PMCA1 complex in retinal photoreceptors.
Regulation and molecular mechanisms of calcium transport genes: do they play a role in calcium transport in the uterine endometrium?
Jeung et al., Ch'ŏngju, South Korea. In J Physiol Pharmacol, 2011
Ca transport genes, i.e., transient receptor potential cation channel subfamily V members 5/6 (TRPV5/6), calbindins, plasma membrane Ca(2+)-ATPase 1 (PMCA1), and NCX1/NCKX3, may play roles in the uterus for Ca transport and reproductive function.
Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle.
Jeung et al., Ch'ŏngju, South Korea. In Mol Reprod Dev, 2011
Immunohistochemical analysis of the distribution of TRPV6 and PMCA1 in the uterus revealed that both proteins are abundantly expressed in the cytoplasm of endometrial and glandular epithelial cells during menstrual phases.
Genome-wide association study of blood pressure and hypertension.
van Duijn et al., Framingham, United States. In Nat Genet, 2009
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
Kim et al., Seoul, South Korea. In Nat Genet, 2009
For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 x 10(-7)).
CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.
Wortis et al., Boston, United States. In Nat Immunol, 2004
Inhibition of plasma membrane calcium-ATPase (PMCA) attenuated these effects, as did disruption by homologous recombination of the gene encoding PMCA4a and PMCA4b.
Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.
Zacharias et al., Rochester, United States. In Physiol Rev, 2001
During mouse embryonic development, PMCA1 is ubiquitously detected from the earliest time points, and all isoforms show spatially overlapping but distinct expression patterns with dynamic temporal changes occurring during late fetal development.
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