The plethora of PMCA isoforms: Alternative splicing and differential expression.
Göttingen, Germany. In Biochim Biophys Acta, Sep 2015
In this review the four different genes of the mammalian plasma membrane calcium ATPase (PMCA) and their spliced isoforms are discussed with respect to their tissue distribution, their differences during development and their importance for regulating Ca²⁺ homeostasis under different conditions.
Ionic homeostasis in brain conditioning.
Napoli, Italy. In Front Neurosci, 2014
The present article will review the role of protein transporters and ionic channels involved in the control of ionic homeostasis in the neuroprotective effect of ischemic preconditioning and post-conditioning in adult brain, with particular regards to the Na(+)/Ca2(+) exchangers (NCX), the plasma membrane Ca2(+)-ATPase (PMCA), the Na(+)/H(+) exchange (NHE), the Na(+)/K(+)/2Cl(-) cotransport (NKCC) and the acid-sensing cation channels (ASIC).
Prions in the urine of patients with variant Creutzfeldt-Jakob disease.
Micronesia. In N Engl J Med, 2014
METHODS: To investigate whether PrP(Sc) can be detected in the urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfolding cyclic amplification (PMCA) technique to amplify minute quantities of PrP(Sc), enabling highly sensitive detection of the protein.
A bimodular mechanism of calcium control in eukaryotes.
Århus, Denmark. In Nature, 2012
However, the structural basis for the activation mechanism is unknown and a key remaining question is how calmodulin-mediated PMCA regulation can cover both basal Ca(2+) levels in the nanomolar range as well as micromolar-range Ca(2+) transients generated by cell stimulation.
Calcium pumps in health and disease.
Padova, Italy. In Physiol Rev, 2009
Two of the pumps have been known for decades (the SERCA and PMCA pumps); one (the SPCA pump) has only become known recently.