Nonclassical Testosterone Signaling: A New Pathway Controlling Spermatogenesis?
In Biol Reprod, Feb 2016
Wider impacts were also uncovered, revealing that germ cell gene expression can be modulated differentially by the actions of each pathway in Sertoli cells, with some genes activated by both classical and non-classical signaling (cKit), whilst others are more effectively induced by the classical pathway (Plzf).
Balancing Stem Cell Self-renewal and Differentiation with PLZF.
Singapore, Singapore. In Stem Cells, Jan 2016
UNASSIGNED: In recent years, the highly conserved promyelocytic leukemia zinc finger (PLZF, also known as ZBTB16, ZNF145) has attracted attention as a multifunctional transcription factor involved in major biological processes during development.
Gene expression during gonocyte transformation into spermatogonial stem cells is not androgen dependent.
Australia. In J Pediatr Surg, Dec 2015
METHODS: Testes from androgen-receptor knockout (ARKO) and wild-type (WT) littermates were collected at postnatal day P0 (birth), P4, P8 for real-time PCR to measure gene expression of mouse VASA homolog (Mvh), anti-Mullerian hormone (Amh), kit oncogene (c-Kit), matrix metalloproteinase-1 (Mt1-mmp), zinc finger, and BTB domain-containing 16 (Plzf) and octamer-binding protein 4 (Oct4).
The transcriptional programs of iNKT cells.
Boston, United States. In Semin Immunol, Feb 2015
The transcription factors EGR2 and PLZF (and microRNA like miR-150) are key regulators of the iNKT cell transcriptome during development.