gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger and BTB domain containing 16

PLZF, ZBTB16
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RAR, ACID, CAN, PML, Histone
Papers using PLZF antibodies
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
Supplier
Higashiyama Shigeki et al., In The Journal of Cell Biology, 2001
... A plasmid for recombinant expression of CFP-tagged PLZF was generated by subcloning the human PLZF cDNA into pECFP-C1 (CLONTECH Laboratories, Inc.) ...
Papers on PLZF
Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.
New
Impact
Golub et al., Chicago, United States. In Nat Immunol, Feb 2016
Using single-cell multiplex transcriptional analysis of 100 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common proximal precursor to these lineages and found that its bifurcation was marked by differential induction of the transcription factors PLZF and TCF1.
Enrichment and culture of spermatogonia from cryopreserved adult bovine testis tissue.
New
Zhang et al., Changchun, China. In Anim Reprod Sci, Feb 2016
The enriched bovine spermatogonia were large round CD9 and promyelocytic leukemia zinc finger protein (PLZF) positive cells, with high nucleocytoplasmic ratios and multiple types including single, paired-, aligned-cells or grape cluster-like colonies in vitro.
Nonclassical Testosterone Signaling: A New Pathway Controlling Spermatogenesis?
New
Smith, In Biol Reprod, Feb 2016
Wider impacts were also uncovered, revealing that germ cell gene expression can be modulated differentially by the actions of each pathway in Sertoli cells, with some genes activated by both classical and non-classical signaling (cKit), whilst others are more effectively induced by the classical pathway (Plzf).
Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.
New
Boudinot et al., Jouy-le-Moutier, France. In Dev Comp Immunol, Jan 2016
UNASSIGNED: The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse.
Balancing Stem Cell Self-renewal and Differentiation with PLZF.
New
Shyh-Chang et al., Singapore, Singapore. In Stem Cells, Jan 2016
UNASSIGNED: In recent years, the highly conserved promyelocytic leukemia zinc finger (PLZF, also known as ZBTB16, ZNF145) has attracted attention as a multifunctional transcription factor involved in major biological processes during development.
Amodiaquine-induced reproductive toxicity in adult male rats.
New
Ma et al., Zhanjiang, China. In Mol Reprod Dev, Jan 2016
Interestingly, AQ-induced damage of spermatogenesis recovered over time, as promyelocytic leukemia zinc-finger (PLZF)-positive, undifferentiated spermatogonia survived AQ treatments.
Acute Promyelocytic Leukemia: A Review and Discussion of Variant Translocations.
Review
New
Nassiri et al., Indianapolis, United States. In Arch Pathol Lab Med, Oct 2015
With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenotypic features as classic APL.
Integrative clinical genomics of advanced prostate cancer.
New
Impact
Chinnaiyan et al., Ann Arbor, United States. In Cell, Jun 2015
We identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.
New
Impact
Singer et al., Bethesda, United States. In Nat Immunol, May 2015
We found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post-transcriptionally regulate PLZF expression and thereby the effector functions of natural killer T cells (NKT cells).
Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review).
Review
New
Jiang et al., Jinan, China. In Oncol Rep, May 2015
C/EBPα expression is suppressed as a result of common leukemia-associated genetic and epigenetic alterations such as AML1-ETO, RARα-PLZF or gene promoter methylation.
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
Review
New
McKenzie et al., Cambridge, United Kingdom. In Genes Immun, Apr 2015
PLZF(-) (promyelocytic leukaemia zinc-finger) CHILPs give rise to lymphoid tissue inducer cells, while PLZF(+) CHILPs have multilineage potential and could give rise to ILCs 1, 2 and 3.
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
New
Impact
Bryceson et al., Huddinge, Sweden. In Immunity, Apr 2015
Functional interrogation demonstrated altered cytokine responsiveness in adaptive NK cells that was linked to reduced expression of the transcription factor PLZF. Furthermore, subsets of adaptive NK cells demonstrated significantly reduced functional responses to activated autologous T cells.
The transcriptional programs of iNKT cells.
Review
New
Brenner et al., Boston, United States. In Semin Immunol, Feb 2015
The transcription factors EGR2 and PLZF (and microRNA like miR-150) are key regulators of the iNKT cell transcriptome during development.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Impact
Brenner et al., Boston, United States. In Nat Immunol, 2015
Invariant natural killer T cells (iNKT cells) are lipid-sensing innate T cells that are restricted by the antigen-presenting molecule CD1d and express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their anti-inflammatory nature, as well as their targets in adipose tissue, are unknown.
[Retrotransposons: selfish DNA or active epigenetic players in somatic cells?].
Review
Guidez, Paris, France. In Med Sci (paris), 2014
However, somatic cells are also proned to TE transposition and use specific mechanisms involving tumor suppressor proteins including p53, Rb and PLZF.
Functional antagonism between Sall4 and Plzf defines germline progenitors.
Impact
GeneRIF
Pandolfi et al., Boston, United States. In Cell Stem Cell, 2012
Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression
Far-infrared therapy induces the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in human umbilical vein endothelial cells.
GeneRIF
Chen et al., Taipei, Taiwan. In Plos One, 2011
Far infrared rays induce the nuclear translocation of PLZF which inhibits VEGF-induced proliferation in HUVECs.
Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.
GeneRIF
Inagami et al., Nashville, United States. In Plos One, 2011
PLZF is an important AT2 receptor binding protein in mediating Ang II induced cardiac hypertrophy through an AT2 receptor-dependent signal pathway.
A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger.
GeneRIF
Bendelac et al., Chicago, United States. In J Immunol, 2011
Although PLZF is known to direct the effector program of natural killer (NK)T cells, this study shows that CD1d naive-like cells express it at a significantly lower amount than NKT cells.
Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient.
GeneRIF
Sant'Angelo et al., New York City, United States. In Plos One, 2010
PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs.
share on facebooktweetadd +1mail to friends