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Phospholipid transfer protein

PLTP
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HDL, CETP, fibrillin-1, HAD, CAN
Papers using PLTP antibodies
Measurement of human plasma phospholipid transfer protein by sandwich ELISA
Supplier
Leon Carlos G et al., In Lipids in Health and Disease, 1999
... PLTP Activity Assay Kit's were obtained from Roar Biomedical (New York, NY, USA) ...
Papers on PLTP
Proteomic analysis of HDL from inbred mice strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway.
New
Heinecke et al., Washington, D.C., United States. In J Lipid Res, Jan 2016
Cholesterol efflux capacity with macrophages strongly and positively correlated with RBP4 and PLTP, but not APOA1.
Paraoxonase-1 activity is positively related to phospholipid transfer protein activity in type 2 diabetes mellitus: Role of large HDL particles.
New
Dallinga-Thie et al., Groningen, Netherlands. In Clin Biochem, Jan 2016
OBJECTIVES: High density lipoprotein (HDL)-associated paraoxonase-1 (PON-1) exerts anti-oxidative properties, whereas phospholipid transfer protein (PLTP) is able to convert mature HDL into larger and smaller HDL particles.
Intake of grape procyanidins during gestation and lactation impairs reverse cholesterol transport and increases atherogenic risk indexes in adult offspring.
New
Caimari et al., Reus, Spain. In J Nutr Biochem, Dec 2015
Conversely, GSPE programming also resulted in up-regulated gene expression of different key components of the RCT process, such as hepatic Npc1, Abcg1, Abca1, Lxra, Srebp2, Lcat, Scarb1 and Pltp, and the repression of microRNA miR-33a expression, a key negative controller of hepatic RCT at the gene expression level.
Optimizing a Male Reproductive Aging Mouse Model by d-Galactose Injection.
New
Lin et al., Taipei, Taiwan. In Int J Mol Sci, Dec 2015
The d-gal-injected groups exhibited RNA transcripts of nine spermatogenesis-related genes (Cycl2, Hk1, Pltp, Utp3, Cabyr, Zpbp2, Speer2, Csnka2ip and Katnb1) that were up- or down-regulated by at least two-fold compared to the control group.
Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.
New
Impact
Cucca et al., Cagliari, Italy. In Nat Genet, Nov 2015
Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3.
RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.
New
Vaidya et al., Boston, United States. In J Am Soc Nephrol, Nov 2015
Using targeted selected reaction monitoring mass spectrometry, we detected three of the ten candidates in human urine: cadherin 11 (CDH11), macrophage mannose receptor C1 (MRC1), and phospholipid transfer protein (PLTP).
Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment.
New
Watanabe et al., Japan. In J Obstet Gynaecol Res, Oct 2015
These genes included PTGDS, GRP, APLP2, PLTP, and FGFRL1.
HDL biogenesis, remodeling, and catabolism.
Review
Chroni et al., Boston, United States. In Handb Exp Pharmacol, 2014
Remodeling and catabolism of HDL is the result of interactions of HDL with cell receptors and other membrane and plasma proteins including hepatic lipase (HL), endothelial lipase (EL), phospholipid transfer protein (PLTP), cholesteryl ester transfer protein (CETP), apolipoprotein M (apoM), scavenger receptor class B type I (SR-BI), ATP-binding cassette transporter G1 (ABCG1), the F1 subunit of ATPase (Ecto F1-ATPase), and the cubulin/megalin receptor.
PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle.
Yan et al., Lanzhou, China. In Genet Mol Res, 2014
In cattle, the mRNA level of PLTP was positively correlated with SFA (P < 0.05), and LPL was positively correlated with MUFA (P < 0.05).
Phospholipid transfer protein in diabetes, metabolic syndrome and obesity.
Review
Yu et al., Taishan, China. In Cardiovasc Hematol Disord Drug Targets, 2013
It has been reported that phospholipid transfer protein (PLTP) is an independent risk factor for human coronary artery disease.
Ox-LDL-induced TGF-β1 production in human alveolar epithelial cells: involvement of the Ras/ERK/PLTP pathway.
GeneRIF
Wen et al., Chengdu, China. In J Cell Physiol, 2012
we provide evidences that induction of TGF-B1 production and Smad3 phosphorylation by Ox-LDL is mediated by Ras/ERK/PLTP pathway in human alveolar epithelial cells.
Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice.
GeneRIF
Jiang et al., United States. In Hepatology, 2012
Our results suggest, for the first time, that the major function of liver PLTP is to drive VLDL production and makes a small contribution to plasma PLTP activity.
Phospholipid transfer protein is differentially expressed in human arterial and venous placental endothelial cells and enhances cholesterol efflux to fetal HDL.
GeneRIF
Panzenboeck et al., Graz, Austria. In J Clin Endocrinol Metab, 2012
PLTP mediates PL transfer and participates in reverse cholesterol transport pathways at the fetoplacental barrier.
Type 2 diabetes mellitus interacts with obesity and common variations in PLTP to affect plasma phospholipid transfer protein activity.
GeneRIF
Dallinga-Thie et al., Groningen, Netherlands. In J Intern Med, 2012
diabetes-environment and diabetes-gene interactions govern plasma PLTP activity
Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism.
Review
Cheung et al., Seattle, United States. In Biochim Biophys Acta, 2012
The understanding of the physiological and pathophysiological role of PLTP has greatly increased since the discovery of PLTP more than a quarter of century ago.
Phospholipid transfer protein in the placental endothelium is affected by gestational diabetes mellitus.
GeneRIF
Panzenboeck et al., Graz, Austria. In J Clin Endocrinol Metab, 2012
Pltp expression is increased in GDM with hyperglycemia and/or hyperinsulinemia contributing. High PLTP activity in fetal serum may enhance conversion of HDL into cholesterol-accepting particles, thereby increasing maternal-fetal cholesterol transfer.
Bioinformatics of the TULIP domain superfamily.
Review
Lupas et al., Tübingen, Germany. In Biochem Soc Trans, 2011
Bioinformatic analyses show that, in addition to its known members, which include BPI, LBP [LPS (lipopolysaccharide)-binding protein)], CETP (cholesteryl ester-transfer protein), PLTP (phospholipid-transfer protein) and PLUNC (palate, lung and nasal epithelium clone) protein, this family also includes other, more divergent groups containing hypothetical proteins from fungi, nematodes and deep-branching unicellular eukaryotes.
Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transport.
Review
Jiang et al., United States. In Curr Atheroscler Rep, 2011
It is known that phospholipid transfer protein (PLTP) impacts both HDL cholesterol level and biological quality of the HDL molecule.
Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency.
Impact
Tall et al., New York City, United States. In Nat Med, 2001
The plasma phospholipid-transfer protein (PLTP) is known to mediate transfer of phospholipids between BLp and HDL during their intravascular metabolism.
Plasma lipid transfer proteins.
Review
Impact
Tall, New York City, United States. In Annu Rev Biochem, 1994
The cholesteryl ester transfer protein (CETP) and the phospholipid transfer protein (PLTP) are members of the lipid transfer/lipopolysaccharide binding gene family.
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