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Pancreatic lipase-related protein 1

PLRP1, pancreatic lipase-related protein 1
hydrolyzes dietary triacylglycerols in the duodenum; may play a role in fat metabolism [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: pancreatic lipase-related protein 2, colipase, HAD, ACID, Inactive
Papers on PLRP1
Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1.
GeneRIF
Fei et al., Shanghai, China. In J Nutr Biochem, 2011
We propose that PLRP1 may function as a metabolic inhibitor in vivo of pancreatic triglyceride lipase-colipase-mediated dietary triglyceride digestion.
Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.
Ma et al., Shanghai, China. In Oncol Rep, 2010
Two proteins were up-regulated, serine proteinase-2 (PRSS2) preproprotein and pancreatic lipase-related protein-1 (PLRP1), and two proteins were down-regulated, chymotrypsinogen B (CTRB) precursor and elastase 3B (ELA3B) preproprotein.
Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules.
Crenon et al., Marseille, France. In Mol Nutr Food Res, 2009
Pancreatic lipase (PL) and pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2) display different functional properties, despite close structures.
Pancreatic lipase-related protein (PY-PLRP) highly expressed in the vitellogenic ovary of the scallop, Patinopecten yessoensis.
Kim et al., Pusan, South Korea. In Comp Biochem Physiol B Biochem Mol Biol, 2008
Sequence analysis of the catalytic domains of PY-PLRP with members of the pancreatic triglyceride lipase (PTL) family suggested that PY-PLRP was related to mammalian PLRP1, PLRP2, and PTL.
Occurrence of pancreatic lipase-related protein-2 in various species and its relationship with herbivore diet.
De Caro et al., France. In Comp Biochem Physiol B Biochem Mol Biol, 2008
The pancreas of carnivorous animals (dogs and cats) does not have any detectable PLRP2, but contains high levels of PL and PLRP1.
Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA.
De Caro et al., Marseille, France. In Biochim Biophys Acta, 2006
Specific antibodies were raised in rabbits using a synthetic HPLRP2 peptide selected for its weak amino acid homology with the corresponding peptides of classical human pancreatic lipase (HPL) and human pancreatic lipase-related protein 1 (HPLRP1).
Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat.
Birk et al., Beersheba, Israel. In Br J Nutr, 2006
Using the exocrine pancreas in vitro AR42J cell model, we studied the direct effects of leptin on pancreatic lipase (PL) secretion and on the mRNA levels of PL and PL-related proteins 1 and 2 (PLRP1, PLRP2).
Constitutive expression of human pancreatic lipase-related protein 1 in Pichia pastoris.
Carrière et al., Marseille, France. In Protein Expr Purif, 2006
High-level constitutive expression of the human pancreatic lipase-related protein 1 (HPLRP1) was achieved using the methylotrophic yeast Pichia pastoris.
Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions.
Borel et al., Marseille, France. In Biochim Biophys Acta, 2006
It has been shown that classical pancreatic lipase (PL) is involved in the luminal hydrolysis of retinyl palmitate (RP), but it is not known whether pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2), two other lipases recovered in the human pancreatic juice, are also involved.
Crystallization of a proteolyzed form of the horse pancreatic lipase-related protein 2: structural basis for the specific detergent requirement.
Hermoso et al., Madrid, Spain. In Acta Crystallogr D Biol Crystallogr, 2004
Horse pancreatic lipase-related proteins PLRP1 and PLRP2 are produced by the pancreas together with pancreatic lipase (PL).
Characterization of pancreatic lipase-related protein 2 isolated from human pancreatic juice.
De Caro et al., Marseille, France. In Biochim Biophys Acta, 2004
Western blotting analysis showed that these antibodies did not react with classical human pancreatic lipase (HPL) or human pancreatic lipase-related protein 1 (HPLRP1) but cross-reacted with native rat PLRP2 (RPLRP2), as well as with recombinant rat and guinea-pig PLRP2 (GPLRP2).
Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats.
Brannon et al., Beersheba, Israel. In Pediatr Res, 2004
The developmental gene expression of pancreatic lipase (PL) and its related proteins (PLRP1 and PLRP2) is anticoordinate.
[Analysis of gene expression profiles among 3 epithelial ovarian tumor subtypes using cDNA and tissue microarrays].
Moch et al., Guangzhou, China. In Ai Zheng, 2004
EPHB6, PTPRF, GFER, ERG25, PLRP1, FLJ22060, and WISP2 were further validated by RNA in situ hybridization in tissue microarray.
Regulation of pancreatic lipase by dietary medium chain triglycerides in the weanling rat.
Brannon et al., Beersheba, Israel. In Pediatr Res, 2004
Pancreatic lipase (PL) and its related protein 1 (PLRP1) are regulated by the amount of dietary fat through an apparent transcriptional mechanism.
The triglyceride lipases of the pancreas.
Review
Lowe, Saint Louis, United States. In J Lipid Res, 2002
In addition to PTL, pancreatic acinar cells synthesize two pancreatic lipase related proteins (PLRP1 and PLRP2), which have a high degree of sequence and structural homology with PTL.
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