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Proteolipid protein 2

PLP2, phosducin-like protein 2
This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010] (from NCBI)
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Top mentioned proteins: PLP, CAN, Ubiquitin, ACID, NSP2
Papers on PLP2
Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury.
Valle et al., Cleveland, United States. In Hum Mol Genet, Jan 2016
Previously, we identified a promoter variant (-113C>A) in PLP2 (proteolipid protein 2) that results in an ∼4-fold reduction of transcript and protein and is overly represented in males with X-linked ID (XLID).
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.
Mesecar et al., West Lafayette, United States. In J Biol Chem, Nov 2015
We report here the x-ray structure of three tandemly linked domains of MHV nsp3, including the papain-like protease 2 (PLP2) catalytic domain, the ubiquitin-like domain 2 (Ubl2), and a third domain that we call the DPUP (domain preceding Ubl2 and PLP2) domain.
Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2.
Zhou et al., Guangzhou, China. In Medicine (baltimore), Aug 2015
Proteolipid protein 2 (PLP2) has been shown to be upregulated in several cancers, including breast cancer, hepatocellular carcinoma, osteosarcoma, and melanoma.
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Kikkert et al., Leiden, Netherlands. In Vet Microbiol, Aug 2015
We have recently shown that the deubiquitinase (DUB) activity of EAV papain-like protease 2 (PLP2) is important for the inhibition of innate immune activation during infection.
Functional architecture of two exclusively late stage pollen-specific promoters in rice (Oryza sativa L.).
Meng et al., Beijing, China. In Plant Mol Biol, Jul 2015
Here, pollen-late-stage-promoter 1 (PLP1) and pollen-late-stage-promoter 2 (PLP2) were characterized using a stable transformation system in rice.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Baker et al., Maywood, United States. In J Virol, May 2015
Here, we tested the effect of altering the Ubl adjacent to PLP2 of MHV on enzyme activity, viral replication, and pathogenesis.
miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia.
Shao et al., Suzhou, China. In Biochem Biophys Res Commun, May 2015
Here, we identified miR-664 and its predicted target gene PLP2 were differentially expressed in T-ALL using bioinformatics methods.
Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom".
van Griensven et al., Belgrade, Serbia. In J Ethnopharmacol, Apr 2015
All the extracts demonstrated cytotoxic effect on four tumor cell lines and not on primary porcine liver cells PLP2.
p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling.
Zhang et al., Dalian, China. In J Biol Chem, Mar 2015
Here, we provide evidence that PLP2, a catalytic domain of the nonstructural protein 3 of human coronavirus NL63 (HCoV-NL63), deubiquitinates and stabilizes the cellular oncoprotein MDM2 and induces the proteasomal degradation of p53.
Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements.
Ferreira et al., Portugal. In Molecules, 2014
The cytotoxicity was determined in four human tumor cell lines (MCF-7, NCI-H460, HeLa and HepG2, and also in non-tumor cells (porcine liver primary cells, PLP2)).
Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunity.
Chen et al., Beijing, China. In Protein Cell, 2014
Here, we show that the membrane-associated papain-like protease PLP2 (PLP2-TM) of coronaviruses acts as a novel autophagy-inducing protein.
New insights into the effects of formulation type and compositional mixtures on the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants.
Ferreira et al., Portugal. In Food Funct, 2014
None of the assayed mixtures resulted to be toxic (up to the maximum assayed dose) for liver primary cells (PLP2), but some samples, especially infusions, showed toxicity for the hepatocellular carcinoma cell line (HepG2).
[Establishment and functional identification of a stable cell line overexpression heme oxygenase-1].
Liu et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2014
The recombinant plasmids were transfected into HEK293T cells to produce the viruses, with the helping plasmids including plp1, plp2, and VSVG.
Cytotoxicity of Portuguese propolis: the proximity of the in vitro doses for tumor and normal cell lines.
Ferreira et al., Portugal. In Biomed Res Int, 2013
To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7-breast adenocarcinoma, NCI-H460-non-small cell lung carcinoma, HCT15-colon carcinoma, HeLa-cervical carcinoma, and HepG2-hepatocellular carcinoma), and non-tumor primary cells (PLP2).
Proteolipid protein 2 is associated with melanoma metastasis.
Kasahara et al., Tokyo, Japan. In Oncol Rep, 2010
PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo.
Yeast phosducin-like protein 2 acts as a stimulatory co-factor for the folding of actin by the chaperonin CCT via a ternary complex.
Willison et al., London, United Kingdom. In J Mol Biol, 2009
In a single ATP-driven cycle, PLP2-CCT-ACT1 complexes yield 30-fold more native actin than CCT-ACT1 complexes.
Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeletal protein function and cell cycle progression.
Leroux et al., Canada. In Mol Biol Cell, 2007
Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2.
X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation.
Wang et al., Baltimore, United States. In Genome Res, 2007
PLP2 is expressed abundantly in the pyramidal cells of hippocampus and granular cells of the cerebellum in the brains of a cohort of males with probable X-linked mental retardation.
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth.
Xiong et al., Augusta, United States. In Nat Cell Biol, 2005
Netrin-1 stimulates PlTPalpha binding to DCC and to phosphatidylinositol (5) phosphate [Pl(5)P], increases its lipid-transfer activity and elevates hydrolysis of phosphatidylinositol bisphosphate (PlP2).
PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells.
Kim et al., South Korea. In Biochem Biophys Res Commun, 2004
PLP2/A4 has a role in the chemotactic processes via CCR1
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