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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Polo-like kinase 3

Plk3, FNK, Polo-like kinase 3, CNK
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Plk1, SNK, CAN, KSR, Bcl-xL
Papers on Plk3
Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells.
Rupasinghe et al., Truro, Canada. In Chem Biol Interact, Jan 2016
Cell cycle essential aurora kinases (AURKα, AURKβ) and polo-like kinases (PLK1, PLK2, PLK3) were also modulated by CUR3d.
Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors.
Hong et al., Taejŏn, South Korea. In Bioorg Med Chem Lett, Dec 2015
Enzymatic kinase assays and docking simulation studies have shown that the natural product wrightiadione displays inhibitory activity toward TrkA and PLK3.
Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma.
Fingas et al., Essen, Germany. In Liver Int, Nov 2015
However, only PLK1 and especially PLK3 were expressed in higher amounts within CCA cells as compared to normal liver.
Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression.
De et al., Nanjing, China. In Oncotarget, Nov 2015
Furthermore, HOXA-AS2 could epigenetically repress the expression of P21, PLK3, and DDIT3 via binding with EZH2 (enhaner of zeste homolog 2), a key component of PRC2; ChIP assays demonstrated that EZH2 could directly bind to the promoter of P21, PLK3 and DDIT3, inducing H3K27 trimethylated.
Toward the development of transcriptional biodosimetry for the identification of irradiated individuals and assessment of absorbed radiation dose.
Kruszewski et al., Warsaw, Poland. In Radiat Environ Biophys, Aug 2015
The mRNA level of 16 genes (ATF3, BAX, BBC3, BCL2, CDKN1A, DDB2, FDXR, GADD45A, GDF15, MDM2, PLK3, SERPINE1, SESN2, TNFRSF10B, TNFSF4, and VWCE) was assessed by reverse transcription quantitative PCR 6, 12, 24, and 48 h after exposure with ITFG1 and DPM1 used as a reference genes.
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
Kirik et al., Lund, Sweden. In Neurobiol Dis, Jun 2015
For this purpose, we took advantage of recombinant adeno-associated viral (rAAV) vectors to deliver polo-like kinase (PLK) 2 or PLK3 in the substantia nigra and investigated whether increased levels of P(S129)-α-syn compromised the function and survival of nigral dopaminergic neurons.
Volasertib for the treatment of acute myeloid leukemia: a review of preclinical and clinical development.
Fiedler et al., Hamburg, Germany. In Future Oncol, 2014
Volasertib is a potent inhibitor of Polo-like kinase (PLK) 1 and to lesser extent also PLK2 and PLK3.
[Genome-wide molecular screening for the identification of new targets in human hepatocellular carcinoma].
Longerich, Heidelberg, Germany. In Pathologe, 2012
For instance, Polo-like kinase 3 (PLK3) is frequently inactivated via promoter hypermethylation in combination with a loss of the second allele at 1p34.1.
Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.
Pinna et al., Padova, Italy. In Biotechniques, 2012
However PLK2 and PLK3 kinases recognize an acidic consensus similar to CK2 when tested on peptide libraries.
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.
Eick et al., München, Germany. In Embo J, 2012
Here, the authors report phosphorylation of Thr4 by Polo-like kinase 3 in mammalian cells.
Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.
Bertrand et al., Montréal, Canada. In Cell Signal, 2011
Bcl-xL phosphorylation at Ser49 by polo-like kinase 3 during cell cycle progression and checkpoints
Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.
Lu et al., Torrance, United States. In J Biol Chem, 2011
hyperosmotic stress can activate the Plk3 signaling pathway that subsequently regulates the AP-1 complex by directly phosphorylating ATF-2 independent from the effects of JNK and p38 activation.
Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
Naik et al., Newark, United States. In Int J Biochem Cell Biol, 2011
Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.
Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.
Naik et al., Newark, United States. In Plos One, 2010
Calcium- and integrin-binding protein 1 is involved in regulating endomitosis, perhaps through its interaction with Plk3
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.
Strebhardt, Frankfurt am Main, Germany. In Nat Rev Drug Discov, 2010
Although the roles of the closely related PLK2, PLK3 and PLK4 in cancer are less well understood, there is evidence showing that PLK2 and PLK3 act as tumour suppressors through their functions in the p53 signalling network, which guards the cell against various stress signals.
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
Geijtenbeek et al., Amsterdam, Netherlands. In Nat Immunol, 2009
DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1.
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Piwnica-Worms et al., Saint Louis, United States. In Cancer Cell, 2008
Phosphorylation by GSK-3beta requires priming of Cdc25A, and this can be catalyzed by polo-like kinase 3 (Plk-3).
KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
Therrien et al., Montréal, Canada. In Oncogene, 2007
Here, through the angle of studies conducted in Drosophila and C. elegans, we present two such proteins, the kinase suppressor of RAS (KSR) and connector enhancer of KSR (CNK) scaffolds, and highlight their implication in a novel mechanism regulating RAS-mediated RAF activation.
Polo-like kinases: a team in control of the division.
Medema et al., Utrecht, Netherlands. In Cell Cycle, 2006
Multiple Plks are present in mammalian cells (Plk1, Plk2/Snk, Plk3/Fnk/Prk, and Plk4/Sak) and Xenopus (Plx1-3), whereas in other species only one member has been identified, like Polo in Drosophila, Cdc5 in budding yeast and Plo1 in fission yeast.
CNK, a RAF-binding multidomain protein required for RAS signaling.
Rubin et al., Berkeley, United States. In Cell, 1998
A screen for mutations that modify a ksr-dependent phenotype identified a novel gene, connector enhancer of ksr (cnk), that functions upstream or in parallel to RAF in the RAS pathway.
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