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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Polo-like kinase 1

Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, PCNA, CDC2, V1a, Aurora
Papers using Plk1 antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Supplier
Polymenis Michael, In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
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Yu Chun-Zhao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
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Barr Francis A. et al., In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
Supplier
Preiss Thomas, In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
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Papers on Plk1
Functional specialization of chordate CDK1 paralogs during oogenic meiosis.
New
Thompson et al., Bergen, Norway. In Cell Cycle, 25 Mar 2015
Differential spatiotemporal dynamics of the odCDK1a, d and e paralogs and the meiotic polo-like kinase 1 (Plk1) and aurora kinase determine the subset of meiotic nuclei in prophase I arrest that will seed growing oocytes and complete meiosis.
Kinome-Level Screening Identifies Inhibition of Polo-Like Kinase-1 (PLK1) as a Target for Enhancing Non-Viral Transgene Expression.
New
Rege et al., Tempe, United States. In J Control Release, 10 Mar 2015
The strongest enhancement was observed with several small-molecule inhibitors of Polo-like Kinase 1 (PLK 1) (e.g.
Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1-CENP-Q Complex from Kinetochores.
New
Lee et al., United States. In J Biol Chem, 10 Mar 2015
UNASSIGNED: Mammalian polo-like kinase 1 (Plk1) is critically required for proper M-phase progression.
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
New
Matsuura et al., Hiroshima, Japan. In Cell Rep, 04 Mar 2015
It was shown that a mitotic kinase, Polo-like kinase 1 (PLK1), is required for cell-proliferation-coupled primary cilia disassembly.
Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines.
New
May et al., Freiburg, Germany. In Leuk Res, 28 Feb 2015
UNASSIGNED: Polo-like kinase 1 (PLK1) is an important regulator of the cell cycle and is overexpressed in various solid and hematological malignancies.
Understanding the Polo Kinase machine.
Review
New
Kachaner et al., Montréal, Canada. In Oncogene, 26 Feb 2015
In all organisms that contain Plks, one Plk family member fulfills several essential functions in the regulation of cell division, and here we refer to this conserved protein as Polo Kinase (Plk1 in humans).
Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
New
Impact
Watanabe et al., Tokyo, Japan. In Nature, 22 Feb 2015
These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
New
Impact
Pagano et al., New York City, United States. In Nat Cell Biol, Jan 2015
Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP.
Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis.
New
Li et al., Beijing, China. In Sci Rep, Dec 2014
Inhibition of Aurora B or expression of the S12A mutant renders reduced interaction between Ataxin-10 and polo-like kinase 1 (Plk1), a kinase previously identified to regulate Ataxin-10 in cytokinesis.
Role of NEK2A in Human Cancer and Its Therapeutic Potentials.
Review
New
Zhan et al., Guangzhou, China. In Biomed Res Int, Dec 2014
Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase.
Emerging therapeutic targets in bladder cancer.
Review
New
Giles et al., United States. In Cancer Treat Rev, Dec 2014
Inhibitors of cell cycle regulators (aurora kinase, polo-like kinase 1, and cyclin-dependent kinase 4) are being investigated in combination with chemotherapy.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
New
Impact
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regulator required to initiate CENP-A deposition in human cells.
Polo-like kinases: structural variations lead to multiple functions.
Review
New
Impact
Bettencourt-Dias et al., Portugal. In Nat Rev Mol Cell Biol, Jul 2014
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response.
Current assessment of polo-like kinases as anti-tumor drug targets.
Review
New
McInnes et al., Columbia, United States. In Expert Opin Drug Discov, Jul 2014
INTRODUCTION: Polo-like kinase (PLK)1 is the most studied of the PLK family and is a serine/threonine kinase that plays pivotal roles in many aspects of mitosis and hence its deregulation is prevalent in various malignant tumor types.
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
New
Impact
Benkirane et al., Montpellier, France. In Cell, Feb 2014
Direct interaction of Vpr with SLX4 induced the recruitment of VPRBP and kinase-active PLK1, enhancing the cleavage of DNA by SLX4-associated MUS81-EME1 endonucleases.
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide.
GeneRIF
Ryu et al., South Korea. In Biomaterials, 2012
analysis of tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
GeneRIF
Lampson et al., Philadelphia, United States. In J Cell Biol, 2012
Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
GeneRIF
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
GeneRIF
Lu et al., Shanghai, China. In Med Sci Monit, 2012
PLK1 could be a progression marker for colorectal cancer patients.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
GeneRIF
Schermer et al., Philadelphia, United States. In Plos One, 2011
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
More papers using Plk1 antibodies
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Supplier
Inagaki Masaki et al., In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
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