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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Dec 2014.

Polo-like kinase 1

Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, PCNA, CDC2, V1a, p53
Papers using Plk1 antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Supplier
Polymenis Michael, In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
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Yu Chun-Zhao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
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Barr Francis A. et al., In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
Supplier
Preiss Thomas, In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
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Papers on Plk1
Kinome wide functional screen identifies role of Polo-like kinase 1 (PLK1) in hormone-independent, ER-positive breast cancer.
New
Arteaga et al., Ad Dānā, Syria. In Cancer Res, 05 Jan 2015
A kinome-wide siRNA screen using a library targeting 720 kinases identified Polo-like kinase 1 (PLK1) as one of the top genes whose downregulation resulted in inhibition of estrogen-independent ER transcriptional activity and growth of LTED cells.
Design, Synthesis, and Evaluation of Non-ATP-Competitive Small-Molecule Polo-Like Kinase 1 (Plk1) Inhibitors.
New
Jiang et al., Nanjing, China. In Arch Pharm (weinheim), 27 Dec 2014
UNLABELLED: A series of small-molecule Plk1 inhibitors targeting the substrate-binding pocket were designed through rational drug design for the first time.
The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor.
New
Westbrook et al., Houston, United States. In Cell Rep, 20 Dec 2014
SCYL1, TEX14, and PLK1 ("STP axis") cooperatively trigger degradation of the REST tumor suppressor protein, a frequent event in human TNBC.
Regulation of Polo-like Kinase 1 by DNA Damage and PP2A/B55α
New
Peng et al., Lincoln, United States. In Cell Cycle, 18 Dec 2014
UNLABELLED: Abstract In addition to governing mitotic progression, Plk1 also suppresses the activation of the G2 DNA damage checkpoint and promotes checkpoint recovery.
Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer.
New
Ethier et al., Charleston, United States. In Mol Oncol, 23 Nov 2014
Expression profiling demonstrated that AREG-activated EGFR regulates gene expression differently than EGF-activated EGFR, and functional analysis via genome-scale shRNA screening identified a set of genes, including PLK1 and BIRC5, that are essential for survival of SUM-149 cells, but are uncoupled from EGFR signaling.
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
New
Zhang et al., United States. In Cell Cycle, Oct 2014
Mechanistically, the function of BRCA1 in promoting DDICA is through binding and recruiting polo-like kinase 1 (PLK1) to the centrosome.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
New
Impact
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regulator required to initiate CENP-A deposition in human cells.
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy.
Review
New
Schöffski et al., Bergen, Norway. In Leukemia, Aug 2014
UNLABELLED: Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology.
Polo-like kinases: structural variations lead to multiple functions.
Review
New
Impact
Bettencourt-Dias et al., Portugal. In Nat Rev Mol Cell Biol, Jul 2014
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response.
Targeting nuclear kinases in cancer: development of cell cycle kinase inhibitors.
Review
New
Bradshaw-Pierce et al., Denver, United States. In Pharmacol Ther, May 2014
The proteins involved include checkpoint kinases (CHK), cyclin-dependent kinases (CDK), which regulate the cell cycle and aurora kinases (AURK) and polo-like kinases (PLK), which regulate mitosis.
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
New
Impact
Benkirane et al., Montpellier, France. In Cell, Feb 2014
Direct interaction of Vpr with SLX4 induced the recruitment of VPRBP and kinase-active PLK1, enhancing the cleavage of DNA by SLX4-associated MUS81-EME1 endonucleases.
The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
Review
New
Ahmad et al., West Lafayette, United States. In Cancer Res, Jan 2014
Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biologic functions continually being identified throughout the cell cycle.
Developments of polo-like kinase 1 (Plk1) inhibitors as anti-cancer agents.
Review
New
Xu et al., China. In Mini Rev Med Chem, Dec 2013
Plk1, playing a key role in multiple steps of mitotic progression, is the most studied member of the family.
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.
Review
New
Impact
Yaffe et al., Cambridge, United States. In Nat Rev Mol Cell Biol, Sep 2013
Such domains include 14-3-3 proteins, WW domains, Polo-box domains (in PLK1), WD40 repeats (including those in the E3 ligase SCF(βTrCP)), BRCT domains (including those in BRCA1) and FHA domains (such as in CHK2 and MDC1).
Cullin' PLK1 from kinetochores.
New
Impact
Rape et al., Berkeley, United States. In Nat Cell Biol, Apr 2013
To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin.
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide.
GeneRIF
Ryu et al., South Korea. In Biomaterials, 2012
analysis of tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
GeneRIF
Lampson et al., Philadelphia, United States. In J Cell Biol, 2012
Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
GeneRIF
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
GeneRIF
Lu et al., Shanghai, China. In Med Sci Monit, 2012
PLK1 could be a progression marker for colorectal cancer patients.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
GeneRIF
Schermer et al., Philadelphia, United States. In Plos One, 2011
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
More papers using Plk1 antibodies
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Supplier
Inagaki Masaki et al., In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
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