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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Polo-like kinase 1

Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, PCNA, V1a, Aurora, CDC2
Papers using Plk1 antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Supplier
Polymenis Michael, In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
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Yu Chun-Zhao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
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Barr Francis A. et al., In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
Supplier
Preiss Thomas, In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
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Papers on Plk1
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
New
Demeure et al., Tempe, United States. In Clin Transl Med, 31 Dec 2016
Polo-like kinase 1 (PLK-1) negatively modulates p53 functioning, promotes MDM2 activity through its phosphorylation, and is involved in the G2/M transition.
Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.
New
Caffrey et al., San Francisco, United States. In Plos Negl Trop Dis, Jan 2016
METHODOLOGY/PRINCIPAL FINDINGS: We show that RNA interference (RNAi) of the Schistosoma mansoni ortholog of human polo-like kinase (huPLK)1 elicits a deleterious phenotypic alteration in post-infective larvae (schistosomula or somules).
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
New
Reddy et al., New York City, United States. In Bioorg Med Chem, Jan 2016
The PLK family consists of five members and of these, the role of PLK1 in human cancer is well documented.
Functions of Polo-Like Kinases: A Journey From Yeast To Humans.
New
Sourirajan et al., Solan, India. In Protein Pept Lett, Dec 2015
Perturbations in PLK functions have disease implications, such as cancer in humans, and thus human PLK1 is targeted for cancer therapeutics.
Collision of ion acoustic solitary waves in a magnetized plasma: Effect of dust grains and trapped electrons.
New
Nishida et al., Delhi, India. In Phys Rev E Stat Nonlin Soft Matter Phys, Dec 2015
By using the extended Poincaré-Lighthill-Kuo (PLK) perturbation method, an analytical expression is obtained for the phase shift that takes place due to the collision of the waves.
Polo-like kinase inhibitors in hematologic malignancies.
Review
New
Wang et al., Buffalo, United States. In Crit Rev Oncol Hematol, Dec 2015
UNASSIGNED: Polo-like kinases (Plk) are key regulators of the cell cycle and multiple aspects of mitosis.
PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.
New
Impact
Matsumoto et al., Nagoya, Japan. In Nat Cell Biol, Aug 2015
Proper spindle orientation depends on centrosome maturation, and Polo-like kinase 1 (PLK1) is known to play a crucial role in this process.
Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
New
Impact
Watanabe et al., Tokyo, Japan. In Nature, Feb 2015
These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Impact
Pagano et al., New York City, United States. In Nat Cell Biol, 2015
Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP.
Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.
Review
Arlot-Bonnemains et al., Rennes, France. In Front Oncol, 2014
Aneuploidy can also result from the loss of cell-cell adhesion and apical-basal cell polarity that also may be regulated by the mitotic kinases (polo-like kinase 1, casein kinase 2, doublecortin-like kinase 1, and Aurora kinases).
PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis.
Review
Kim et al., Ch'unch'ŏn, South Korea. In Biomed Res Int, 2014
PLK-1 (Polo-like kinase-1) is a crucial mitotic protein kinase that plays an essential role in both the onset of G2/M transition and cytokinesis.
Putting a bit into the polo-box domain of polo-like kinase 1.
Review
Lee et al., Bethesda, United States. In J Anal Sci Technol, 2014
UNASSIGNED: Polo-like kinase 1 (Plk1) plays key roles in regulating various mitotic processes that are critical for cellular proliferation.
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.
Review
Guarguaglini et al., Roma, Italy. In Front Oncol, 2014
Bora has been described as an essential cofactor of AURKA for phosphorylation-mediated activation of the mitotic kinase polo-like kinase 1 (Plk1) at the G2/M transition.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
Impact
Cheeseman et al., Cambridge, United States. In Cell, 2014
Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regulator required to initiate CENP-A deposition in human cells.
Polo-like kinases: structural variations lead to multiple functions.
Review
Impact
Bettencourt-Dias et al., Portugal. In Nat Rev Mol Cell Biol, 2014
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response.
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide.
GeneRIF
Ryu et al., South Korea. In Biomaterials, 2012
analysis of tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
GeneRIF
Lampson et al., Philadelphia, United States. In J Cell Biol, 2012
Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
GeneRIF
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
GeneRIF
Lu et al., Shanghai, China. In Med Sci Monit, 2012
PLK1 could be a progression marker for colorectal cancer patients.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
GeneRIF
Schermer et al., Philadelphia, United States. In Plos One, 2011
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
More papers using Plk1 antibodies
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Supplier
Inagaki Masaki et al., In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
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