GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Polo-like kinase 1
Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from
NCBI)
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Papers using
Plk1
antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Supplier
In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Supplier
In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
Supplier
In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
Supplier
In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
more suppliersSupplier
In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
Papers on
Plk1
Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors.
New
Boston, United States. In Biomaterials, 30 Apr 2013
In addition, SSB/PLK1 siRNA encapsulated in HA-PEI/PEG nanosystems demonstrated dose dependent and target specific gene knockdown in both sensitive and resistant A549 lung cancer cells overexpressing CD44 receptors.
Scale-up and intensification of S-1-(2-chlorophenyl)-ethanol bioproduction: Economic evaluation of whole cell-catalyzed reduction of o-chloroacetophenone.
New
Graz, Austria. In Biotechnol Bioeng, 08 Apr 2013
The product, S-1-(2-chlorophenyl)-ethanol, is a key chiral intermediate in the synthesis of polo-like kinase 1 inhibitors, a new class of chemotherapeutic drugs.
Ubiquitylation-dependent localization of PLK1 in mitosis.
New
Impact
Zürich, Switzerland. In Nat Cell Biol, 03 Apr 2013
Polo-like kinase 1 (PLK1) critically regulates mitosis through its dynamic localization to kinetochores, centrosomes and the midzone.
Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit.
New
Baltimore, United States. In Embo J, 01 Apr 2013
Here, we show that the p27/p25 heterodimer undergoes mitotic phosphorylation by cyclin-dependent kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo-like kinase 1 (Plk1) at kinetochores.
Emerging mitotic inhibitors for non-small cell carcinoma.
New
Napoli, Italy. In Expert Opin Emerg Drugs, 31 Mar 2013
Furthermore, the identification of novel mitotic drug targets other than microtubules has gained recently much attention, such as aurora kinases, Polo-like kinase1 (PLK1), kinesin spindle protein (KSP), and centromeric protein E (CENPE).
An Analog-Sensitive Approach Identifies Basal Body Rotation and Flagellum Attachment Zone Elongation as Key Functions of PLK in trypanosoma brucei.
New
Vienna, Austria. In Mol Biol Cell, 27 Mar 2013
In the parasite Trypanosoma brucei, the single PLK homolog TbPLK is necessary for the assembly of a series of essential organelles that position and adhere the flagellum to the cell surface.
Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity.
Review
New
Changsha, China. In Carcinogenesis, Nov 2012
Moreover, the regulatory effect of miRNA in radiosensitivity can be enhanced when interacting with various key molecules, including H2AX, BRCA1, ATM, DNA-PK, RAD51, Chk1, Cdc25A, p53, PLK1, HIF-1 and VEGF, which are involved in these processes.
A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.
Review
New
Oss, Netherlands. In Br J Pharmacol, Jun 2012
In addition, we recommend which inhibitors to use for studying the biology of the 20 most investigated kinases that are clinically relevant: Abl (ABL1), AKT1, ALK, Aurora A/B, CDKs, MET, CSF1R (FMS), EGFR, FLT3, ERBB2 (HER2), IKBKB (IKK2), JAK2/3, JNK1/2/3 (MAPK8/9/10), MEK1/2, PLK1, PI3Ks, p38α (MAPK14), BRAF, SRC and VEGFR2 (KDR).
Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?
Review
New
Bergen, Norway. In Expert Opin Investig Drugs, May 2012
INTRODUCTION: Five human polo-like kinases (PLKs) have been identified, and PLK1 - 4 seem to interact with Aurora kinases and act as cell cycle regulators in both normal and malignant human cells.
Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development.
Review
New
West Lafayette, United States. In Protein Cell, Mar 2012
Polo-like kinase 1 (Plk1), a well-characterized member of serine/threonine kinases Plk family, has been shown to play pivotal roles in mitosis and cytokinesis in eukaryotic cells.
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
GeneRIF
Seoul, South Korea. In J Cell Biol, 2012
The PLK1-mediated phosphorylation of PCNT initiates centrosome maturation by organizing the spindle pole-specific PCM lattice.
Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion.
GeneRIF
Houston, United States. In J Biol Chem, 2012
Sororin is phosphorylated by Cdk1/cyclin B at prophase and acts as a docking protein to bring Plk1 into proximity with SA2, resulting in the phosphorylation of SA2 and the removal of cohesin complexes from chromosomal arms.
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.
GeneRIF
West Lafayette, United States. In Mol Cell Biol, 2011
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress
Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.
GeneRIF
Frederick, United States. In Clin Exp Metastasis, 2011
High PLK1 expression is associated with brain metastasis in breast cancer.
Polo-like kinases inhibitors.
Review
Bologna, Italy. In Curr Med Chem, 2011
PLK1 is the most studied member of the family.
Systematic discovery of TLR signaling components delineates viral-sensing circuits.
Impact
Cambridge, United States. In Cell, 2011
In particular, we find that Polo-like kinases (Plk) 2 and 4 are essential components of antiviral pathways in vitro and in vivo and activate a signaling branch involving a dozen proteins, among which is Tnfaip2, a gene associated with autoimmune diseases but whose role was unknown.
Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease.
GeneRIF
West Lafayette, United States. In Aging (albany Ny), 2011
Data show that Polo-like kinase 1 activity is elevated in Alzheimer's disease as indicated by the increased phosphorylation signal of p150Glued, a Plk1-specific substrate.
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Impact
Boston, United States. In Cell, 2011
Importantly, we demonstrate that PTEN mutant and PTEN null states are not synonymous as they are differentially sensitive to pharmacological inhibition of APC-CDH1 targets such as PLK1 and Aurora kinases.
Shared and separate functions of polo-like kinases and aurora kinases in cancer.
Review
Impact
Utrecht, Netherlands. In Nat Rev Cancer, 2010
Within the polo-like kinase family, the emphasis for targeted therapies has been on polo-like kinase 1 (PLK1), and in the aurora kinase family drugs have been developed to specifically target aurora kinase A (AURKA; also known as STK6) and/or aurora kinase B (AURKB; also known as STK12).
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.
More papers using
Plk1
antibodies
Review
Impact
Frankfurt am Main, Germany. In Nat Rev Drug Discov, 2010
The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1-cyclin B1 and Aurora kinases to orchestrate a wide range of critical cell cycle events.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
In Cell Death & Disease, 2001
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Supplier
In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
