Application of RNAi to Genomic Drug Target Validation in Schistosomes.
London, United Kingdom. In Plos Negl Trop Dis, 31 May 2015
RNAi knockdown of these kinase genes failed to affect adult worm viability but, like Sm-aPKC, knockdown of Polo-like kinase 1, Sm-PLK1 (Smp_009600) and p38-MAPK, Sm-MAPK p38 (Smp_133020) resulted in an increased mortality of schistosomula after 2-3 weeks, an effect more marked in the presence of human red blood cells (hRBC).
The role of Plk3 in oncogenesis.
Frankfurt am Main, Germany. In Oncogene, 27 May 2015
Plk1, which has been validated as a cancer target, came into the focus of many pharmaceutical companies for the development of small-molecule inhibitors as anticancer agents.
Emerging therapeutic targets in bladder cancer.
United States. In Cancer Treat Rev, Feb 2015
Inhibitors of cell cycle regulators (aurora kinase, polo-like kinase 1, and cyclin-dependent kinase 4) are being investigated in combination with chemotherapy.
Understanding the Polo Kinase machine.
Montréal, Canada. In Oncogene, Feb 2015
In all organisms that contain Plks, one Plk family member fulfills several essential functions in the regulation of cell division, and here we refer to this conserved protein as Polo Kinase (Plk1 in humans).
Role of NEK2A in human cancer and its therapeutic potentials.
More papers using
Guangzhou, China. In Biomed Res Int, Dec 2014
Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...