Understanding the Polo Kinase machine.
Montréal, Canada. In Oncogene, 26 Feb 2015
In all organisms that contain Plks, one Plk family member fulfills several essential functions in the regulation of cell division, and here we refer to this conserved protein as Polo Kinase (Plk1 in humans).
Role of NEK2A in Human Cancer and Its Therapeutic Potentials.
Guangzhou, China. In Biomed Res Int, Dec 2014
Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase.
Emerging therapeutic targets in bladder cancer.
United States. In Cancer Treat Rev, Dec 2014
Inhibitors of cell cycle regulators (aurora kinase, polo-like kinase 1, and cyclin-dependent kinase 4) are being investigated in combination with chemotherapy.
Current assessment of polo-like kinases as anti-tumor drug targets.
More papers using
Columbia, United States. In Expert Opin Drug Discov, Jul 2014
INTRODUCTION: Polo-like kinase (PLK)1 is the most studied of the PLK family and is a serine/threonine kinase that plays pivotal roles in many aspects of mitosis and hence its deregulation is prevalent in various malignant tumor types.
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...