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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Polo-like kinase 1

Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, PCNA, CDC2, V1a, p53
Papers using Plk1 antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Polymenis Michael, In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
Yu Chun-Zhao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
Barr Francis A. et al., In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
Preiss Thomas, In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
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Papers on Plk1
GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.
Alfandari et al., Amherst Center, United States. In Mol Biol Cell, 08 Nov 2014
We show that ADAM13 function to promote CNC migration is regulated by two phosphorylation events involving GSK3 and Polo-like kinase (Plk).
Systematic analysis of the phosphoproteome and kinase-substrate networks in the mouse testis.
Sha et al., Nanjing, China. In Mol Cell Proteomics, 07 Nov 2014
In particular, the analyses proposed that the activities of POLO-like kinases (PLKs) might be dramatically higher, while the prediction was experimentally validated by detecting and comparing the phosphorylation levels of pT210, an indicator of PLK1 activation, in testis and other tissues.
Mono-anionic Phosphopeptides Produced by Unexpected Histidine Alkylation Exhibit High Plk1 Polo-box Domain-binding Affinities and Enhanced Antiproliferative Effects in HeLa Cells.
Burke et al., Frederick, United States. In Biopolymers, 04 Nov 2014
UNLABELLED: Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1.
Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery.
Matthess et al., Frankfurt am Main, Germany. In Expert Opin Drug Discov, 29 Oct 2014
UNLABELLED: The Polo-like kinase 1 (Plk1) plays a key role in regulating a broad spectrum of critical cell cycle events.
Vanillin-derived antiproliferative compounds influence Plk1 activity.
Spänkuch et al., Frankfurt am Main, Germany. In Bioorg Med Chem Lett, 16 Oct 2014
The molecules are derivatives of the lead compound SBE13, a potent inhibitor of the inactive conformation of human polo-like kinase 1 (Plk1).
SPDEF Inhibits Prostate Carcinogenesis by Disrupting a Positive Feedback Loop in Regulation of the Foxm1 Oncogene.
Kalin et al., Cincinnati, United States. In Plos Genet, 30 Sep 2014
Transgenic over-expression of SPDEF inhibited mRNA and protein levels of Foxm1, a transcription factor critical for tumor cell proliferation, and reduced expression of Foxm1 target genes, including Cdc25b, Cyclin B1, Cyclin A2, Plk-1, AuroraB, CKS1 and Topo2alpha.
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regulator required to initiate CENP-A deposition in human cells.
Polo-like kinases: structural variations lead to multiple functions.
Bettencourt-Dias et al., Portugal. In Nat Rev Mol Cell Biol, Jul 2014
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response.
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
Benkirane et al., Montpellier, France. In Cell, Feb 2014
Direct interaction of Vpr with SLX4 induced the recruitment of VPRBP and kinase-active PLK1, enhancing the cleavage of DNA by SLX4-associated MUS81-EME1 endonucleases.
The role of polo-like kinase 1 in carcinogenesis: cause or consequence?
Ahmad et al., West Lafayette, United States. In Cancer Res, Jan 2014
Polo-like kinase 1 (Plk1) is a well-established mitotic regulator with a diverse range of biologic functions continually being identified throughout the cell cycle.
Developments of polo-like kinase 1 (Plk1) inhibitors as anti-cancer agents.
Xu et al., China. In Mini Rev Med Chem, Dec 2013
Plk1, playing a key role in multiple steps of mitotic progression, is the most studied member of the family.
PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation.
Yu et al., Shanghai, China. In Plos One, Dec 2013
Proteolysis of Rap1GAP requires the PLK1 kinase and β-TrCP ubiquitin ligase complex.
Current clinical trials with polo-like kinase 1 inhibitors in solid tumors.
Yim, South Korea. In Anticancer Drugs, Nov 2013
Polo-like kinase 1 (PLK1) has been investigated as a target for cancer therapy for several years.
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.
Yaffe et al., Cambridge, United States. In Nat Rev Mol Cell Biol, Sep 2013
Such domains include 14-3-3 proteins, WW domains, Polo-box domains (in PLK1), WD40 repeats (including those in the E3 ligase SCF(βTrCP)), BRCT domains (including those in BRCA1) and FHA domains (such as in CHK2 and MDC1).
Cullin' PLK1 from kinetochores.
Rape et al., Berkeley, United States. In Nat Cell Biol, Apr 2013
To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin.
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide.
Ryu et al., South Korea. In Biomaterials, 2012
analysis of tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
Lampson et al., Philadelphia, United States. In J Cell Biol, 2012
Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
Lu et al., Shanghai, China. In Med Sci Monit, 2012
PLK1 could be a progression marker for colorectal cancer patients.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
Schermer et al., Philadelphia, United States. In Plos One, 2011
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
More papers using Plk1 antibodies
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Potempa J S et al., In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Inagaki Masaki et al., In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Fang Guowei et al., In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
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