gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Polo-like kinase 1

Plk1, Polo-like kinase 1, PLK
human homolog catalyzes the phosphorylation of a Golgi reassembly stacking protein (GRASP65); may play a role in Golgi apparatus fragmentation and reorganization during mitosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, PCNA, CDC2, V1a, Aurora
Papers using Plk1 antibodies
Phosphorylation of Ataxin-10 by polo-like kinase 1 is required for cytokinesis.
Supplier
Polymenis Michael, In PLoS ONE, 2010
... The siRNA ON-Target plus SMARTpool to Plk1 was used to deplete Plk1 (Thermo Scientific Dharmacon) ...
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... University of Liverpool, England, UK), mouse anti-Myc (clone 9E10), rabbit anti-Myc (both from Sigma-Aldrich), mouse anti-Plk1 (Santa Cruz Biotechnology, Inc.), mouse anti-PPP2CA (BD), ...
Chemotherapy for recurrent and metastatic cervical cancer
Supplier
Yu Chun-Zhao et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... After antigen retrieval, sections were stained for the expression of PLK-1 (BD Biosciences, San Diego, CA) (1:100)detected ...
Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis
Supplier
Barr Francis A. et al., In The Journal of Cell Biology, 2005
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), aurora B (mouse AIM1; ...
The Ensembl core software libraries.
Supplier
Preiss Thomas, In PLoS ONE, 2003
... The non-targeting control siRNA (siGenome2) and PLK1 siRNA were purchased from Dharmacon/Thermo Scientific Inc ...
more suppliers
Papers on Plk1
PLK1 and HOTAIR accelerate proteasomal degradation of SUZ12 and ZNF198 during hepatitis B virus-induced liver carcinogenesis.
New
Andrisani et al., Lyon, France. In Cancer Res, 08 May 2015
Cells where HBV is replicating exhibit increased expression of PLK1 kinase and reduced levels of two transcription repression factors that bind to each other, SUZ12, an essential subunit of the transcriptional repressor PRC2, and ZNF198, which stabilizes the histone deacetylase component LSD1.
How I treat refractory and early relapsed acute myeloid leukemia.
New
Ganser et al., Hannover, Germany. In Blood, 07 May 2015
for Polo-like kinase 1 (PLK-1), and aminopeptidase), inhibitors of mutated isocitrate dehydrogenase 1 (IDH1) and IDH2, antibody-based therapies and cell-based therapies.
Crucial Genes and Pathways in Chicken Germ Stem Cells Differentiation.
New
Li et al., Yangzhou, China. In J Biol Chem, 06 May 2015
We identified thousands of differentially expressed genes (DEGs) in this process and from these we chose 173 candidate genes from which 98 genes involved in cell differentiation, 19 in the metabolic process and 56 in the differentiation and metabolic processes, like GAL9, AMH, PLK1 and PSMD7 and so on.
Targeting polo-like kinase 1 in acute myeloid leukemia.
Review
New
Brandwein, Edmonton, Canada. In Ther Adv Hematol, 30 Apr 2015
Polo-like kinase 1 (Plk1) plays a number of important roles in the passage of cells through mitosis.
Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe.
New
Poon et al., Hong Kong, Hong Kong. In Oncotarget, 20 Apr 2015
Given that PLK1 and Aurora kinases possess both unique functions as well as co-regulate multiple mitotic events, whether pharmacological inhibition of these kinases together can enhance mitotic catastrophe remains an outstanding issue to be determined.
PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.
New
Cassinelli et al., Milano, Italy. In Oncotarget, 12 Apr 2015
Downregulation of the mitotic kinase PLK1 was found associated with apoptosis induced by SN38 (CPT11 active metabolite).
Emerging therapeutic targets in bladder cancer.
Review
New
Giles et al., United States. In Cancer Treat Rev, Feb 2015
Inhibitors of cell cycle regulators (aurora kinase, polo-like kinase 1, and cyclin-dependent kinase 4) are being investigated in combination with chemotherapy.
Understanding the Polo Kinase machine.
Review
New
Kachaner et al., Montréal, Canada. In Oncogene, Feb 2015
In all organisms that contain Plks, one Plk family member fulfills several essential functions in the regulation of cell division, and here we refer to this conserved protein as Polo Kinase (Plk1 in humans).
Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
New
Impact
Watanabe et al., Tokyo, Japan. In Nature, Feb 2015
These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
New
Impact
Pagano et al., New York City, United States. In Nat Cell Biol, Jan 2015
Cep68 degradation is initiated by PLK1 phosphorylation of Cep68 on Ser 332, allowing recognition by βTrCP.
Role of NEK2A in human cancer and its therapeutic potentials.
Review
New
Zhan et al., Guangzhou, China. In Biomed Res Int, Dec 2014
Additionally, critical roles in many aspects of cancer cell growth, proliferation, metastasis, and drug resistance have been assigned to some of these centrosomal kinases, such as polo-like kinase 1 (PLk1) and Aurora-A kinase.
[Interplay between primary cilia and cell cycle].
Review
New
Spassky et al., Paris, France. In Med Sci (paris), Nov 2014
So, recent studies show that its formation and its resorption are closely linked to molecular actors of the cellular cycle, as for example Aurora A or PLK1 (polo-like kinase 1).
Polo-like kinase 1 licenses CENP-A deposition at centromeres.
New
Impact
Cheeseman et al., Cambridge, United States. In Cell, Aug 2014
Here, we identify polo-like kinase 1 (Plk1) as a centromere-localized regulator required to initiate CENP-A deposition in human cells.
Polo-like kinases: structural variations lead to multiple functions.
Review
New
Impact
Bettencourt-Dias et al., Portugal. In Nat Rev Mol Cell Biol, Jul 2014
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response.
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
New
Impact
Benkirane et al., Montpellier, France. In Cell, Feb 2014
Direct interaction of Vpr with SLX4 induced the recruitment of VPRBP and kinase-active PLK1, enhancing the cleavage of DNA by SLX4-associated MUS81-EME1 endonucleases.
In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide.
GeneRIF
Ryu et al., South Korea. In Biomaterials, 2012
analysis of tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.
GeneRIF
Lampson et al., Philadelphia, United States. In J Cell Biol, 2012
Plk1 dynamics at kinetochores control two critical mitotic processes: initially establishing correct kinetochore-microtubule attachments and subsequently silencing the spindle checkpoint.
Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
GeneRIF
Mizuno et al., Sendai, Japan. In J Biol Chem, 2012
Fry also binds to Aurora A and promotes Plk1 activity by binding to the polo-box domain of Plk1 and by facilitating Aurora A-mediated Plk1 phosphorylation at Thr-210.
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells.
GeneRIF
Lu et al., Shanghai, China. In Med Sci Monit, 2012
PLK1 could be a progression marker for colorectal cancer patients.
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
GeneRIF
Schermer et al., Philadelphia, United States. In Plos One, 2011
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1.
More papers using Plk1 antibodies
Host-pathogen interactions: leukocyte phagocytosis and associated sequelae
Supplier
Potempa J S et al., In Cell Death & Disease, 2001
... anti-SR-A (clone SRA-E5, Trans Genic Inc., Kobe, Japan) and anti-LOX-1, anti-MARCO and anti-CD36 (clones 23C11, PLK1 and FA6-152, respectively, Cell Sciences, Canton, MA, USA) ...
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
Supplier
Inagaki Masaki et al., In The Journal of Cell Biology, 2000
... Plk1-targeted siRNA duplexes (Liu and Erikson, 2002) were obtained from QIAGEN.
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
Supplier
Fang Guowei et al., In The Journal of Cell Biology, 1998
... antibodies were obtained as follows: 3F3/2 ascite from Boston Biologicals, mAb and rabbit antibody against Plk1 (for immunofluorescence in HeLa cells) from Santa Cruz Biotechnology, Inc., monoclonal Plk1 antibody ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Commercially available antibodies were used to α-tubulin (mouse DM1A; Sigma-Aldrich), Plk1 (mouse SC-17783; Santa Cruz Biotechnology, Inc.), Aurora A (rabbit AB12875; ...
share on facebooktweetadd +1mail to friends