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Plexin C1

Plexin C1, PLXNC1, VESPR
This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: JMH, cofilin, CAN, V1a, Actin
Papers on Plexin C1
Gas5 Exerts Tumor-suppressive Functions in Human Glioma Cells by Targeting miR-222.
Xue et al., Shenyang, China. In Mol Ther, Dec 2015
We showed that the introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222.
Semaphorin 7A plays a critical role in IgE-mediated airway inflammation in mice.
Yoshino et al., Kōbe, Japan. In Eur J Pharmacol, Nov 2015
In histological analysis, the epithelial cells, blood vessels, and inflammatory cells in the lungs of IgE-sensitized mice showed SEMA7A expression; plexin C1 for the receptor was expressed in the inflammatory cells.
Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever.
Dewals et al., Liège, Belgium. In J Virol, Apr 2015
AlHV-sema showed a predicted three-dimensional structure very similar to sema7A and conserved key residues in sema7A-plexinC1 interaction.
Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis.
Elias et al., Providence, United States. In Cancer Res, Mar 2015
We found that Chi3l1 was induced during pulmonary melanoma metastasis and that this induction was regulated by the semaphorin Sema7a, interacting in stimulatory or inhibitory ways with its β1 integrin or Plexin C1 receptors, respectively.
Retrograde signaling for climbing fiber synapse elimination.
Kano et al., Tokyo, Japan. In Cerebellum, Feb 2015
Conversely, knockdown of Sema7A in PCs or either of the two receptors for Sema7A, plexinC1 (PlxnC1) and integrinB1 (ItgB1), in CFs impaired CF synapse elimination.
Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma.
Kato et al., Nagoya, Japan. In Am J Cancer Res, 2014
We found that the expression level of Plexin C1 (PlxnC1), a suppressor for melanoma, in a melanoma from an Ednrb(+/-);RET-mouse was drastically decreased compared to that in a melanoma from a RET-mouse.
Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence.
Giacobini et al., Saint-Pierre-des-Corps, France. In Nat Commun, 2014
We demonstrate that Semaphorin7A, expressed by tanycytes, plays a dual role, inducing the retraction of GnRH terminals and promoting their ensheathment by tanycytic end feet via the receptors PlexinC1 and Itgb1, respectively.
Differentially expressed genes in metastatic advanced Egyptian bladder cancer.
Abu-Taleb et al., Cairo, Egypt. In Asian Pac J Cancer Prev, 2014
RESULTS: Five hundred and sixteen genes were differentially expressed of which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1, and SRP68 genes were involved in 33 different pathways.
The plexin C1 receptor promotes acute inflammation.
Rosenberger et al., Tübingen, Germany. In Eur J Immunol, 2014
Previous work has shown the proinflammatory capacity of the guidance cue semaphorin (Sema) 7a, but the role of one of its target receptors, the plexin C1 (PLXNC1) receptor is to date unknown.
Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury.
Rosenberger et al., Tübingen, Germany. In Mucosal Immunol, 2014
Recent work has demonstrated that the guidance protein Semaphorin 7A propagates the infiltration of neutrophils into an hypoxic tissue site, yet the role of its target receptor Plexin C1 (PLXNC1) during lung injury is to date unknown.
Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development.
Pasterkamp et al., Utrecht, Netherlands. In Semin Cell Dev Biol, 2013
These effects are mediated by two receptors, plexinC1 and integrins.
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
Zhang et al., Dallas, United States. In Elife, 2012
Here we present the crystal structures of the active dimer of zebrafish PlexinC1 cytoplasmic region in the apo state and in complex with Rap.
Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.
He et al., Chicago, United States. In Cell, 2010
Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.
Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.
Fender et al., Rochester, United States. In J Invest Dermatol, 2009
Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.
The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis.
Scott et al., New Haven, United States. In Am J Dermatopathol, 2009
significant loss of Plexin C1 in metastatic melanoma compared with primary melanoma, suggesting the possibility that the Plexin C1 receptor is a tumor suppressor protein for melanoma
Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1.
Negishi et al., Kyoto, Japan. In J Biol Chem, 2009
Plexin-C1 displayed R-Ras GAP activity and inhibited cell migration
Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration.
Kolodkin et al., Baltimore, United States. In Bmc Dev Biol, 2006
Sema7A and plexinC1 expression patterns are consistent with these proteins serving both cooperative and separate functions during neural development
Plexin A is a neuronal semaphorin receptor that controls axon guidance.
Goodman et al., Berkeley, United States. In Cell, 1999
In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin.
A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR.
Spriggs et al., Seattle, United States. In Immunity, 1998
The vaccinia virus A39R protein is a member of the semaphorin family.
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