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Plexin A3

plexin A3, PLXNA3, XAP6
The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Neuropilin-1, Semaphorin-3A, neuropilin-2, SET, CAN
Papers on plexin A3
A cytosolic juxtamembrane interface modulates plexin A3 oligomerization and signal transduction.
Berger et al., Bethlehem, United States. In Plos One, 2014
Consistent with this pattern of PlxnA3 dimerization in the presence of ligand and co-receptor, destabilizing mutations to PlxnA3 homodimerization (M1281F) are able to rescue motor patterning defects in sidetracked zebrafish embryos, whereas mutations that enhance PlxnA3 homodimerization (M1281L) are not.
Neural cell adhesion molecule NrCAM regulates Semaphorin 3F-induced dendritic spine remodeling.
Maness et al., Chapel Hill, United States. In J Neurosci, 2014
NrCAM formed a complex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Npn-2-binding sequence (TARNER) in the extracellular Ig1 domain.
On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio.
Chen et al., Taiwan. In Plos One, 2013
Several significant pathways, including chemokine, Phosphatidylinositide 3-kinases, and axon guidance signaling pathway and their cross-talks through PI3K, PAK2, and PLXNA3 were identified to coordinate for neurogenesis and angiogenesis, which are essential for the restoration of the injured brain.
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Lichtenthaler et al., München, Germany. In Proteomics, 2013
Additionally, several candidate substrates with a function in neurite outgrowth and axon guidance, such as plexin A3 and glypican-1 were identified, pointing to a function of Bace1 in neurodevelopment.
Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3.
Spitzer et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2013
Combination of PlexinA3 knockdown with suppression of Ca(2+) activity in single PMN produced a synergistic increase in the incidence of pathfinding errors.
Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish.
Granato et al., Philadelphia, United States. In Plos One, 2012
Furthermore, we find that null mutants of the guidance receptor plexin A3 display identical motor axon branching defects, and time lapse analysis reveals that precocious branch formation in turnout and plexin A3 mutants is due to increased stability of otherwise short-lived axonal protrusions.
Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.
Yoshida et al., Cincinnati, United States. In Plos One, 2012
Here we show that both plexinA1 and plexinA3 are expressed by SAG neurons, and plexinA1/plexinA3 double mutant mice show defects in afferent projections of SAG neurons in the inner ear.
Plexin A3 is involved in semaphorin 3F-mediated oligodendrocyte precursor cell migration.
Huang et al., Nehe, China. In Neurosci Lett, 2012
As co-receptors for semaphorin 3F(sema3F), the expression and role of neuropilin-2 (NRP2) and plexin A3 in OPC migration are unclear.
Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration.
Kathryn Iovine et al., Bethlehem, United States. In Dev Biol, 2012
Of these, nrp2a, plxna1, and plxna3 are expressed in the regenerating fin.
Expression patterns of Sema3F, PlexinA4, -A3, Neuropilin1 and -2 in the postnatal mouse molar suggest roles in tooth innervation and organogenesis.
Kettunen et al., Bergen, Norway. In Acta Odontol Scand, 2012
MATERIALS AND METHODS: Cellular mRNA expression patterns of Sema3F as well as neuropilin 1 (Npn1), neuropilin 2 (Npn2), plexinA3 and plexinA4 receptors were analyzed by sectional in situ hybridization in the mouse molar tooth during postnatal days 0-7.
Semaphorin-plexin signalling genes associated with human breast tumourigenesis.
Griffiths et al., Gold Coast, Australia. In Gene, 2012
in vitro analysis on PLXNA3 also suggest that this gene may have some form of growth suppressive role in breast cancer, in addition to a similar role for the gene previously reported in ovarian cancer.
Progesterone and 1,25-dihydroxyvitamin D₃ inhibit endometrial cancer cell growth by upregulating semaphorin 3B and semaphorin 3F.
Syed et al., Bethesda, United States. In Mol Cancer Res, 2011
Expression of SEMAs and their receptors was assessed in tissue microarrays by immunohistochemistry. SEMA3B, SEMA3F, and plexin A3 were expressed strongly in normal endometrial tissues, whereas grade-dependent decreases were found in endometrial carcinomas.
Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.
Kolodkin et al., Baltimore, United States. In Neuron, 2011
Sema5A and Sema5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors both in vitro and in vivo.
Presence of histone H3 acetylated at lysine 9 in male germ cells and its distribution pattern in the genome of human spermatozoa.
Steger et al., Gießen, Germany. In Reprod Fertil Dev, 2010
H3K9ac was associated with gene promoters (CRAT, G6PD, MCF2L), exons (SOX2, GAPDH, STK11IP, FLNA, PLXNA3, SH3GLB2, CTSD) and intergenic regions (TH) in fertile men and revealed shifts of the distribution pattern in ejaculated spermatozoa of infertile men.
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
Kolodkin et al., Baltimore, United States. In Nature, 2010
Mice with null mutations in genes encoding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (PlexA3, also known as Plxna3), exhibit increased dentate gyrus (DG) granule cell (GC) and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution.
Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.
Ivashkiv et al., New York City, United States. In Hum Immunol, 2009
Data show that the expression of Sema3A receptors (neuropilin-1 (NRP-1), NRP-2, plexin A1, plexin A2, and plexin A3) significantly increased during M-CSF-mediated differentiation of monocytes into macrophages.
Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance.
Granato et al., Philadelphia, United States. In Development, 2007
Plexin A3 plays an additional role in motor axonal morphogenesis.
Novel mutations affecting axon guidance in zebrafish and a role for plexin signalling in the guidance of trigeminal and facial nerve axons.
Okamoto et al., Wako, Japan. In Development, 2007
Plxna3 acts with its ligand Sema3a1 for fasciculation and correct target selection of the Vp and VII motor axons.
PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish.
Becker et al., Australia. In J Neurosci, 2007
study shows plexinA3 is a crucial receptor for axon guidance cues in primary motor neurons
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