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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pleckstrin 2

pleckstrin-2, PLEK2
Top mentioned proteins: Actin, HAD, ACID, PI3K, CAN
Papers on pleckstrin-2
Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.
Ji et al., Chicago, United States. In Haematologica, 2014
Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in actin dynamics and protection of early stage terminal erythroblasts from oxidative damage.
Transcriptome profiling of whole blood cells identifies PLEK2 and C1QB in human melanoma.
Fujita et al., Aurora, United States. In Plos One, 2010
expression of PLEK2, the strongest gene to classify melanoma patients, in CD45(-) subsets illustrates the importance of analyzing whole blood cells for biomarker studies
Two populations of double minute chromosomes harbor distinct amplicons, the MYC locus at 8q24.2 and a 0.43-Mb region at 14q24.1, in the SW613-S human carcinoma cell line.
Bernheim et al., Villejuif, France. In Cytogenet Genome Res, 2008
The 0.43-Mb amplified and overexpressed region contains the PLEK2, PIGH, ARG2, VTI1B, RDH11, and ZFYVE26 genes.
Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading.
Fukui et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2007
These results suggest that PLEK2 is involved in actin rearrangement in a PI 3-kinase dependent manner.
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.
Abrams et al., Philadelphia, United States. In Blood, 2007
pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation.
Cloning, expression and chromosomal assignment of human pleckstrin 2.
Miyamoto et al., Fukui, Japan. In Mol Biol Rep, 2005
Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines.
Pleckstrin homology domains and the cytoskeleton.
Abrams et al., Philadelphia, United States. In Febs Lett, 2002
Examples of these PH domain-containing proteins include certain Dbl family guanine nucleotide exchange factors, protein kinase B, PhdA, and pleckstrin-2.
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