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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phospholipase C, delta 4

PLCdelta4, Phospholipase Cdelta4, PLCdelta2
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] (from NCBI)
Papers on PLCdelta4
Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
GeneRIF
Cocco et al., Bologna, Italy. In Faseb J, 2012
These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
Physiological functions of phospholipase C delta-type.
GeneRIF
Nakamura et al., Hachiōji, Japan. In Adv Enzyme Regul, 2007
PLCd4 is required for the acrosome reaction in fertilization.
Identification and analysis of the promoter region of the human PLC-delta4 gene.
GeneRIF
Rha et al., Seoul, South Korea. In Mol Biol Rep, 2007
Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 binding site played important roles in the promoter activity.
Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
GeneRIF
Tamiya-Koizumi et al., Nagoya, Japan. In J Biochem, 2006
It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon
The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.
GeneRIF
Balla et al., Bethesda, United States. In J Biol Chem, 2004
PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal
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