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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phospholipase C, delta 4

PLCdelta4, Phospholipase Cdelta4, PLCdelta2
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011] (from NCBI)
Papers on PLCdelta4
Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells.
Cocco et al., Bologna, Italy. In Faseb J, 2012
These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARgamma as a novel molecular target of nuclear PLCs.
Physiological functions of phospholipase C delta-type.
Nakamura et al., Hachiōji, Japan. In Adv Enzyme Regul, 2007
PLCd4 is required for the acrosome reaction in fertilization.
Identification and analysis of the promoter region of the human PLC-delta4 gene.
Rha et al., Seoul, South Korea. In Mol Biol Rep, 2007
Serial deletion analysis identified the core PLC-delta4 promoter region as being between -402 and -67, in which an E-box and an AP-1 binding site played important roles in the promoter activity.
Disruption of phospholipase Cdelta4 gene modulates the liver regeneration in cooperation with nuclear protein kinase C.
Tamiya-Koizumi et al., Nagoya, Japan. In J Biochem, 2006
It is concluded that PLC delta4 regulates the liver regeneration in cooperation with nuclear PKC alpha and epsilon
The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.
Balla et al., Bethesda, United States. In J Biol Chem, 2004
PLCdelta(1) and PLCdelta(4) are probably differentially regulated in distinct cellular compartments by PI(4,5)P(2) and the PH domain of PLCdelta(4) does not act as a localization signal
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