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Phospholipase C, delta 1

PLCdelta1, phospholipase C-delta1
This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: PLC, delta1, PLCgamma, HAD, CAN
Papers on PLCdelta1
Membrane curvature modulation of protein activity determined by NMR.
Review
Schlame et al., Hamilton, Canada. In Biochim Biophys Acta, 2015
Among the examples discussed are antimicrobial peptides, proteins affecting membrane fusion, rhodopsin, protein kinase C, phospholipase C-delta1, phosphatidylinositol-3 kinase-related kinases and tafazzin.
Epigenetic inactivation of PLCD1 in chronic myeloid leukemia.
GeneRIF
Chen et al., Chongqing, China. In Int J Mol Med, 2012
PLCD1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of chronic myeloid leukemia.
Coronary vasospasm induced in transgenic mouse with increased phospholipase C-δ1 activity.
GeneRIF
Okumura et al., Hirosaki, Japan. In Circulation, 2012
Increased PLC-delta1 activity causes enhanced coronary vasomotility such as that seen in patients with coronary spastic angina.
Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice.
GeneRIF
Fukami et al., Hachiōji, Japan. In Nat Commun, 2011
Loss of phospholipase Cdelta1 from keratinocytes causes features of interleukin-17-associated inflammatory skin diseases.
[Of genes and nails].
GeneRIF
Dereure, Montpellier, France. In Ann Dermatol Venereol, 2011
Mutations in this gene cause hereditary porcelain nails. Review.
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells.
Fukami et al., Hachiōji, Japan. In Biochem Biophys Res Commun, 2011
The syntenin-2 postsynaptic density protein/disc large/zona occludens (PDZ) domain and pleckstrin homology domain of phospholipase C-delta1 (PLCδ1 PHD) possess high affinity for phosphatidylinositol-4,5-bisphosphate (PI(4,5)P(2)) mainly localized to the nucleus and plasma membrane, respectively.
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome.
GeneRIF
Lothe et al., Oslo, Norway. In Plos One, 2010
Significantly deregulated pathways in colorectal cancer were identified and repression of PLCD1 and PLCE1 expression, was validated.
The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2.
GeneRIF
Scarlata et al., Stony Brook, United States. In J Biol Chem, 2010
Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2
Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.
Fukami et al., Tokyo, Japan. In Cancer Sci, 2010
Sequestering of PI(4,5)P(2) by overexpression of the phospholipase C (PLC) delta1-pleckstrin homology (PH) domain, a specific probe for PI(4,5)P(2), also blocked invadopodia formation, while a mutated PLCdelta1-PH domain that lacks PI(4,5)P(2)-binding activity had no effect.
Calcium fluxes cause nuclear shrinkage and the translocation of phospholipase C-delta1 into the nucleus.
Yagisawa et al., Japan. In Neurosci Lett, 2010
Phospholipase C-delta1 (PLCdelta1) is the most fundamental form of the eukaryotic PLC and thought to play important roles in the regulation of cells.
Nonmuscle myosin IIA (myosin heavy polypeptide 9): a novel class of signal transducer mediating the activation of G alpha h/phospholipase C-delta 1 pathway.
Huang et al., Taipei, Taiwan. In Endocrinology, 2010
Upon the stimulation of higher levels of extracellular FSH (>1000 IU/liter), classical FSH-R induces the phosphorylation of MyH9, the dissociation of active GTP-bound G alpha h from FSH-R:MyH9 complexes, and the elicitation of G alpha h/PLC-delta 1 pathway-dependent Ca(2+)-influx in rat SCs.
Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.
Cao et al., Providence, United States. In Cancer Res, 2010
PI-PLCbeta1, PI-PLCbeta3, PI-PLCbeta4, PI-PLCgamma1, and PI-PLCgamma2, but not PI-PLCbeta2 and PI-PLCdelta1, were detectable in FLO cells by Western blot analysis.
Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme?
Review
Scarlata et al., Antibes, France. In Cell Signal, 2007
The recently solved structure of a major region of PLC-beta2 together with the structure of PLC-delta1 and a wealth of biochemical studies poises the system towards an understanding of the mechanism through which their regulations occurs.
Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+.
Review
GeneRIF
Yagisawa, Japan. In J Cell Biochem, 2006
In this review, recent findings regarding the molecular machineries and mechanisms of the nucleocytoplasmic shuttling of PLCdelta1 will be discussed.
A genetically encoded photosensitizer.
Impact
Lukyanov et al., Moscow, Russia. In Nat Biotechnol, 2006
We demonstrate the utility of KillerRed for light-induced killing of Escherichia coli and eukaryotic cells and for inactivating fusions to beta-galactosidase and phospholipase Cdelta1 pleckstrin homology domain.
Ral: mediator of membrane trafficking.
Review
Robinson et al., Australia. In Int J Biochem Cell Biol, 2005
RalA is a positive regulator of calcium-evoked exocytosis via binding phospholipase D and is involved in G protein coupled receptor signalling by binding phospholipase C-delta1.
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.
Impact
Kanaho et al., Yokohama, Japan. In Cell, 1999
PLD2 similarly translocates to the ruffles, as does the PH domain of phospholipase Cdelta1, indicating locally elevated PI(4,5)P2.
Neuronal signaling systems and ethanol dependence.
Review
Pandey, Chicago, United States. In Mol Neurobiol, 1997
The decreased PLC activity during chronic ethanol exposure may be caused by a decrease in the protein levels of the PLC-beta 1 isozyme but not of PLC-delta 1 or PLC-gamma 1 isozymes in the rat cerebral cortex.
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Impact
Sigler et al., New Haven, United States. In Cell, 1996
The X-ray crystal structure of the high affinity complex between the pleckstrin homology (PH) domain from rat phospholipase C-delta 1 (PLC-delta 1) and inositol-(1,4,5)-trisphosphate (Ins(1,4,5)P3) has been refined to 1.9 A resolution.
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Impact
Gierschik et al., Heidelberg, Germany. In Nature, 1993
In the latter cells, PLC-beta 1, but not PLC-gamma 1 or PLC-delta 1, may be activated by members of the alpha q-subfamily of the G protein alpha-subunits.
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