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Heparan sulfate proteoglycan 2

PLC
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: V1a, CAN, ACID, HAD, Akt
Papers using PLC antibodies
Effect of Rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
Gibbins J M et al., In Journal of Thrombosis and Haemostasis, 2006
... Anti-Syk (N-19, LR), anti-PPARγ (E8), anti-LAT, anti-PLCγ2 antibodies and protein A/G agarose were purchased from Santa Cruz Biotechnology (Autogen Bioclear UK) ...
Activation of protein kinase Czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation
Supplier
Chen Chien-Ho et al., In Journal of Biomedical Science, 2001
... Inhibitors to ERK (PD98059), MAPK-ERK-kinase (MEK) (U0126), p38 (SB203580), JNK (SP600125), PI-PLC (U73122), PKA (KT5720), calcium (BAPTA-AM), and PKC (chelery chloride) were purchased from Tocris Bioscience (Bristol, UK) ...
VEGF receptor signal transduction.
Supplier
Kume Tsutomu, In PLoS ONE, 2000
... used: rabbit anti-phospho-ERK1/2 (Thr 202/Tyr 204, Cell Signaling #9101L); rabbit anti-ERK1/2 (Cell Signaling #9102); rabbit anti-phospho-PLC-γ (Tyr 783, Cell Signaling #2821S); rabbit anti-PLC-γ (Cell ...
Integrin-dependent activation of MAP kinasea link to shape-dependent cell proliferation
Supplier
Le T. Duong et al., In The Journal of Cell Biology, 1994
... -transferase (GST) fusion proteins of PLC-γ1 were from Santa Cruz Biotechnology, Inc ...
Papers on PLC
Gastrin Decreases Na+, K+-ATPase Activity via a PI3 Kinase- and PKC-Dependent Pathway in Human Renal Proximal Tubule Cells.
New
Jose et al., Washington, United Kingdom. In Am J Physiol Endocrinol Metab, Feb 2016
The gastrin-mediated phosphorylation of Na(+), K(+)-ATPase was also inhibited by U73122, a phospholipase-C (PLC) inhibitor.
PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.
New
Bertagnolo et al., Ferrara, Italy. In Mol Carcinog, Feb 2016
Invasive breast tumors belonging to different molecular subtypes are characterized by over-expression of PLC-β2, whose amount positively correlates with the malignant evolution of breast neoplasia and supports the invasive potential of breast tumor cells.
Sperm contributions to oocyte activation: more that meets the eye.
New
Messinis et al., Lárisa, Greece. In J Assist Reprod Genet, Feb 2016
Today, the sperm factor hypothesis has gained general acceptance, according to which a sperm molecule, either phospholipase C (PLCζ) or a post-acrosomal sheath WW domain-binding protein (PAWP), diffuses into the ooplasm initiating a molecular cascade involving mainly the phosphoinositide pathway.
Plant Phospholipases D and C and Their Diverse Functions in Stress Responses.
Review
New
Wang et al., Wuhan, China. In Prog Lipid Res, Feb 2016
PLDs and PLCs in plants occur in different forms: the calcium-dependent phospholipid binding domain-containing PLDs (C2-PLDs), the plekstrin homology and phox homology domain-containing PLDs (PX/PH-PLDs), phosphoinositide-specific PLC (PI-PLC), and non-specific PLC (NPC).
The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis.
Review
New
Payrastre et al., Toulouse, France. In Adv Biol Regul, Jan 2016
While the phospholipase C (PLC) pathway has a crucial role in platelet activation, it is now well established that at least one class I phosphoinositide 3-kinase (PI3K) is also mandatory for proper platelet functions.
Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.
New
Ishige et al., Yotsukaidō, Japan. In Oncol Lett, Dec 2015
HLF and PLC/PRF/5 HCC cells were cultured in the presence of niclosamide.
Primary phospholipase C and brain disorders.
Review
New
Suh et al., Ulsan, South Korea. In Adv Biol Regul, Dec 2015
UNASSIGNED: In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs).
Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.
New
Impact
Smith et al., Jupiter, United States. In Cell, Dec 2015
Activation by a DRD1 agonist produced non-canonical signal transduction via Gαq-PLC-IP3-Ca(2+) at the expense of canonical DRD1 Gαs cAMP signaling to result in CaMKII activation, glutamate receptor exocytosis, synaptic reorganization, and expression of early markers of hippocampal synaptic plasticity.
Therapeutic efficacy of brucea javanica oil emulsion (BJOE) combined with transcatheter hepatic arterial chemoembolization (TACE) in patients with primary liver cancer.
Zhao et al., Weifang, China. In Int J Clin Exp Med, 2014
This study is to investigate the effects of brucea javanica oil emulsion (BJOE) combined with transcatheter hepatic arterial chemoembolization (TACE) on primary liver cancer (PLC) and the related mechanisms.
Infectious Entry Pathway of Enterovirus B Species.
Review
Huttunen et al., Jyväskylä, Finland. In Viruses, 2014
Many cellular factors regulating the efficient entry have recently been associated with macropinocytic uptake, such as Rac1, serine/threonine p21-activated kinase (Pak1), actin, Na/H exchanger, phospholipace C (PLC) and protein kinase Cα (PKCα).
Phospholipase C-β1 Hypofunction in the Pathogenesis of Schizophrenia.
Review
Lee et al., Taejŏn, South Korea. In Front Psychiatry, 2014
Previous studies indicate decreased expression of phospholipase C-β1 (PLC-β1) in the brains of patients with schizophrenia.
Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
Impact
Weiss et al., San Francisco, United States. In Nat Immunol, 2014
Inhibition of Csk(AS) in thymocytes, without engagement of the TCR, induced potent activation of SFKs and proximal TCR signaling up to phospholipase C-γ1 (PLC-γ1).
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Impact
Malarkannan et al., Milwaukee, United States. In Nat Immunol, 2013
Both of those effector functions required the kinases Lck, Fyn and PI(3)K (subunits p85α and p110δ) and the signaling protein PLC-γ2.
Phospholipase signalling networks in cancer.
Impact
Ryu et al., South Korea. In Nat Rev Cancer, 2012
Phospholipases (PLC, PLD and PLA) are essential mediators of intracellular and intercellular signalling.
Photomechanical responses in Drosophila photoreceptors.
Impact
Franze et al., Cambridge, United Kingdom. In Science, 2012
Phototransduction in Drosophila microvillar photoreceptor cells is mediated by a G protein-activated phospholipase C (PLC).
Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation.
GeneRIF
Yamada et al., Bethesda, United States. In Matrix Biol, 2012
Cartilage perlecan promoted activation of VEGF/VEGFR by binding to the VEGFR of endothelial cells.
Perlecan-deficient mutation impairs corneal epithelial structure.
GeneRIF
Arikawa-Hirasawa et al., Tokyo, Japan. In Invest Ophthalmol Vis Sci, 2012
The Hspg2/-Tg corneal epithelium exhibited thinner wing cell layers and a decreased number of Ki67-positive cells, but no dead cells, compared with the WT corneal epithelium.
Rhodopsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster is independent of retinal phospholipase C-β signaling.
GeneRIF
Stanewsky et al., London, United Kingdom. In J Biol Rhythms, 2012
Light reception mediated by Rh5 and Rh6 must utilize either a different (nonretinal) phospholipase C-beta enzyme or alternative signaling mechanisms, at least in terms of clock-relevant photoreception
A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: a potential marker of physical activity.
GeneRIF
Upton et al., Brisbane, Australia. In Plos One, 2011
activity mediated release of LG3/endorepellin into the circulation may represent a biological mechanism for the known inverse association between physical activity and cancer risk/survival
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