Activation of protein kinase Czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation
In Journal of Biomedical Science, 2001
... Inhibitors to ERK (PD98059), MAPK-ERK-kinase (MEK) (U0126), p38 (SB203580), JNK (SP600125), PI-PLC (U73122), PKA (KT5720), calcium (BAPTA-AM), and PKC (chelery chloride) were purchased from Tocris Bioscience (Bristol, UK) ... VEGF receptor signal transduction.
In PLoS ONE, 2000
... used: rabbit anti-phospho-ERK1/2 (Thr 202/Tyr 204, Cell Signaling #9101L); rabbit anti-ERK1/2 (Cell Signaling #9102); rabbit anti-phospho-PLC-γ (Tyr 783, Cell Signaling #2821S); rabbit anti-PLC-γ (Cell ...
Sperm contributions to oocyte activation: more that meets the eye.
Lárisa, Greece. In J Assist Reprod Genet, Feb 2016
Today, the sperm factor hypothesis has gained general acceptance, according to which a sperm molecule, either phospholipase C (PLCζ) or a post-acrosomal sheath WW domain-binding protein (PAWP), diffuses into the ooplasm initiating a molecular cascade involving mainly the phosphoinositide pathway.
Plant Phospholipases D and C and Their Diverse Functions in Stress Responses.
Wuhan, China. In Prog Lipid Res, Feb 2016
PLDs and PLCs in plants occur in different forms: the calcium-dependent phospholipid binding domain-containing PLDs (C2-PLDs), the plekstrin homology and phox homology domain-containing PLDs (PX/PH-PLDs), phosphoinositide-specific PLC (PI-PLC), and non-specific PLC (NPC).
Primary phospholipase C and brain disorders.
Ulsan, South Korea. In Adv Biol Regul, Dec 2015
UNASSIGNED: In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs).
Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor.
Jupiter, United States. In Cell, Dec 2015
Activation by a DRD1 agonist produced non-canonical signal transduction via Gαq-PLC-IP3-Ca(2+) at the expense of canonical DRD1 Gαs cAMP signaling to result in CaMKII activation, glutamate receptor exocytosis, synaptic reorganization, and expression of early markers of hippocampal synaptic plasticity.
Infectious Entry Pathway of Enterovirus B Species.
Jyväskylä, Finland. In Viruses, 2014
Many cellular factors regulating the efficient entry have recently been associated with macropinocytic uptake, such as Rac1, serine/threonine p21-activated kinase (Pak1), actin, Na/H exchanger, phospholipace C (PLC) and protein kinase Cα (PKCα).