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Platelet-derived growth factor alpha polypeptide

Platelet-Derived Growth Factor
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PDGFR, vascular endothelial growth factor, V1a, HAD
Papers using Platelet-Derived Growth Factor antibodies
Insulin Resistance and Atherosclerosis
Nigro Julie et al., In Cardiovascular Diabetology, 2005
... Phenformin, metformin, chlorpropamide, dimethylsulfoxide (DMSO), platelet-derived growth factor (PDGF), Whatman 3 MM chromatography paper and DEAE-Sephacel were obtained from Sigma Aldrich (St Louis, MO) ...
Papers on Platelet-Derived Growth Factor
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
In ACD patients, serum levels of CCL5 were elevated, whereas levels of TFF3, soluble intercellular adhesion molecule-1 (sICAM-1), and platelet-derived growth factor (PDGF)-AB/BB were found to be lower during the remission phase of the disease.
Implications of anticoagulants and gender on cell counts and growth factor concentration in platelet-rich plasma and platelet-rich gel supernatants from rabbits.
Carmona et al., Manizales, Colombia. In Vet Comp Orthop Traumatol, Feb 2016
The concentrations of transforming growth factor beta 1 and platelet-derived growth factor BB were assayed by ELISA.
Biomarkers for wound healing and their evaluation.
Chandra et al., India. In J Wound Care, Feb 2016
Macrophages, neutrophils, fibroblasts and platelets release cytokines molecules including TNF-α, interleukins (ILs) and growth factors, of which platelet-derived growth factor (PDGF) holds the greatest importance.
Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model.
Shoichet et al., Toronto, Canada. In Biomaterials, Feb 2016
The hydrogel, modified with the RGD peptide and platelet-derived growth factor (PDGF-A), promoted early survival and integration of grafted cells.
Standard first-line chemotherapy with or without nintedanib for advanced ovarian cancer (AGO-OVAR 12): a randomised, double-blind, placebo-controlled phase 3 trial.
AGO Study Group led Gynecologic Cancer Intergroup (GCIG)/European Network of Gynaecologic Oncology Trials Groups (ENGOT) Intergroup Consortium et al., Essen, Germany. In Lancet Oncol, Jan 2016
Nintedanib, an oral triple angiokinase inhibitor of VEGF receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has shown activity in phase 2 trials in this setting.
Lenvatinib: Role in thyroid cancer and other solid tumors.
Habra et al., Houston, United States. In Cancer Treat Rev, Jan 2016
Lenvatinib targets vascular endothelial growth factor receptors 1-3 (VEGFR1-3), fibroblast growth factor receptors 1-4 (FGFR-1-4), RET, c-kit, and platelet-derived growth factor receptor α (PDGFRα).
The corneal fibrosis response to epithelial-stromal injury.
Wilson et al., Cleveland, United States. In Exp Eye Res, Jan 2016
Structural and functional abnormalities of the regenerated EBM facilitate prolonged entry of epithelium-derived growth factors such as transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) into the stroma that both drive development of mature myofibroblasts from precursor cells and lead to persistence of the cells in the anterior stroma.
Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial.
Heinrich et al., Berlin, Germany. In Bmc Cancer, Dec 2015
BACKGROUND: Several small studies indicated that the genotype of KIT or platelet-derived growth factor receptor-α (PDGFRA) contributes in part to the level of clinical effectiveness of sunitinib in gastrointestinal stromal tumor (GIST) patients.
Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma.
Tanihara et al., Kumamoto, Japan. In Plos One, Dec 2015
RESULTS: In UG cases, mean interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, tumor necrosis factor (TNF)-α, platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, and VEGF levels were 171.1, 214.5, 2791.7,
Identification of an oncogenic RAB protein.
Sawyers et al., New York City, United States. In Science, Nov 2015
Furthermore, oncogenic RAB35 is sufficient to drive platelet-derived growth factor receptor α to LAMP2-positive endomembranes in the absence of ligand, suggesting that there may be latent oncogenic potential in dysregulated endomembrane trafficking.
Nilotinib versus imatinib as first-line therapy for patients with unresectable or metastatic gastrointestinal stromal tumours (ENESTg1): a randomised phase 3 trial.
Demetri et al., Lyon, France. In Lancet Oncol, May 2015
BACKGROUND: Nilotinib inhibits the tyrosine kinase activity of ABL1/BCR-ABL1 and KIT, platelet-derived growth factor receptors (PDGFRs), and the discoidin domain receptor.
KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.
Emile et al., Helsinki, Finland. In J Clin Oncol, Mar 2015
PURPOSE: Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their single mutations is known incompletely.
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer.
Sherman et al., Aş Şanamayn, Syria. In N Engl J Med, Mar 2015
BACKGROUND: Lenvatinib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, platelet-derived growth factor receptor α, RET, and KIT, showed clinical activity in a phase 2 study involving patients with differentiated thyroid cancer that was refractory to radioiodine (iodine-131).
Profile of nintedanib in the treatment of solid tumors: the evidence to date.
Schwarz et al., South Bend, United States. In Onco Targets Ther, 2014
Nintedanib (formally known as BIBF 1120) is a triple angiokinase inhibitor of VEGF, fibroblast growth factor, platelet-derived growth factor signaling with lesser activity against RET, Flt-3, and Src.
Overview of fundamental study of pazopanib in cancer.
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
Through the exploration of inhibitors of vascular endothelial growth factor receptor (VEGFR)-2, deemed as the major angiogenesis pathway, pazopanib was found as a small molecular pan-VEGFR and pan-platelet-derived growth factor receptor (PDGFR) inhibitor, with suitable pharmacodynamic and pharmacokinetic parameters to be an oral drug.
The role of the kidney in the systemic elimination of interleukin 6, platelet-derived growth factor and transforming growth factor beta.
Paczek et al., Warsaw, Poland. In Cytokine, 2012
The kidney takes part in the elimination of IL-6 and PDGF from systemic circulation. The kidney does not take part in the elimination of TGF-beta.
Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility.
Granata et al., Torino, Italy. In Hum Reprod, 2012
Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility
The increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma.
de Araújo et al., Campinas, Brazil. In J Clin Pathol, 2012
Report increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenoma.
Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: impact on melanoma cell proliferation.
Anderegg et al., Leipzig, Germany. In J Invest Dermatol, 2012
Melanoma cell-derived platelet-derived growth factor (PDGF)-AA and PDGF-CC were identified as major mediators that signal through PDGFR-alpha and thus induce HAS2-mediated HA synthesis in fibroblasts
Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.
Holland et al., New York City, United States. In Plos One, 2011
analysis of astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment
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