Platelet-Derived Growth Factor
Insulin Resistance and Atherosclerosis
In Cardiovascular Diabetology, 2005
... Phenformin, metformin, chlorpropamide, dimethylsulfoxide (DMSO), platelet-derived growth factor (PDGF), Whatman 3 MM chromatography paper and DEAE-Sephacel were obtained from Sigma Aldrich (St Louis, MO) ...
Platelet-Derived Growth Factor
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
In ACD patients, serum levels of CCL5 were elevated, whereas levels of TFF3, soluble intercellular adhesion molecule-1 (sICAM-1), and platelet-derived growth factor (PDGF)-AB/BB were found to be lower during the remission phase of the disease.
Biomarkers for wound healing and their evaluation.
India. In J Wound Care, Feb 2016
Macrophages, neutrophils, fibroblasts and platelets release cytokines molecules including TNF-α, interleukins (ILs) and growth factors, of which platelet-derived growth factor (PDGF) holds the greatest importance.
Lenvatinib: Role in thyroid cancer and other solid tumors.
Houston, United States. In Cancer Treat Rev, Jan 2016
Lenvatinib targets vascular endothelial growth factor receptors 1-3 (VEGFR1-3), fibroblast growth factor receptors 1-4 (FGFR-1-4), RET, c-kit, and platelet-derived growth factor receptor α (PDGFRα).
The corneal fibrosis response to epithelial-stromal injury.
Cleveland, United States. In Exp Eye Res, Jan 2016
Structural and functional abnormalities of the regenerated EBM facilitate prolonged entry of epithelium-derived growth factors such as transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) into the stroma that both drive development of mature myofibroblasts from precursor cells and lead to persistence of the cells in the anterior stroma.
Factors Influencing Aqueous Proinflammatory Cytokines and Growth Factors in Uveitic Glaucoma.
Kumamoto, Japan. In Plos One, Dec 2015
RESULTS: In UG cases, mean interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, tumor necrosis factor (TNF)-α, platelet-derived growth factor (PDGF)-AA, PDGF-AB/BB, and VEGF levels were 171.1, 214.5, 2791.7,
Identification of an oncogenic RAB protein.
New York City, United States. In Science, Nov 2015
Furthermore, oncogenic RAB35 is sufficient to drive platelet-derived growth factor receptor α to LAMP2-positive endomembranes in the absence of ligand, suggesting that there may be latent oncogenic potential in dysregulated endomembrane trafficking.
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer.
Aş Şanamayn, Syria. In N Engl J Med, Mar 2015
BACKGROUND: Lenvatinib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, fibroblast growth factor receptors 1 through 4, platelet-derived growth factor receptor α, RET, and KIT, showed clinical activity in a phase 2 study involving patients with differentiated thyroid cancer that was refractory to radioiodine (iodine-131).
Overview of fundamental study of pazopanib in cancer.
Tianjin, China. In Thorac Cancer, 2014
Through the exploration of inhibitors of vascular endothelial growth factor receptor (VEGFR)-2, deemed as the major angiogenesis pathway, pazopanib was found as a small molecular pan-VEGFR and pan-platelet-derived growth factor receptor (PDGFR) inhibitor, with suitable pharmacodynamic and pharmacokinetic parameters to be an oral drug.