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Fucosidase, alpha-L- 2, plasma

plasma alpha-L-fucosidase, FUCA2, alpha-L-fucosidase II, alpha-l-fucosidase 2
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: alpha-L-Fucosidase, HAD, CAN, Neuraminidase, Plasminogen
Papers on plasma alpha-L-fucosidase
Modulation of expression in BEAS-2B airway epithelial cells of α-L-fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of α-L-fucosidase 2.
Irwin et al., Dublin, Ireland. In Mol Cell Biochem, 2014
The regulation of FUCA1 and FUCA2 gene expression and enzyme activity in response to asthma-associated Th2 cytokines and, for contrast, Th1 cytokine IFN-γ, were investigated in a human airway cell line.
Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
Osanto et al., Leiden, Netherlands. In Plos One, 2013
We characterized the specificity of this immune response, and detected a dominant T cell population recognizing a novel minor histocompatibility antigen (MiHA) designated LB-FUCA2-1V.
Stabilization of membrane-associated alpha-L-fucosidase by the human sperm equatorial segment.
Bean et al., Bethlehem, United States. In Int J Androl, 2009
Here, we report seminal plasma alpha-L-fucosidase activity rapidly decreased within 24 h.
Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.
GeneRIF
Lin et al., Taipei, Taiwan. In Proc Natl Acad Sci U S A, 2009
Findings not only demonstrate an important connection between FUCA2 and the adhesion, growth, and pathogenicity of H. pylori, but also support the idea that FUCA2 is a potential target for diagnosis and therapy of H. pylori-related diseases.
Serum fucosylation changes in oral cancer and oral precancerous conditions: alpha-L-fucosidase as a marker.
GeneRIF
Patel et al., Ahmadābād, India. In Cancer, 2008
serum alpha-L-fucosidase was identified as a useful marker for close monitoring of patients during post-treatment follow-up
A case report of remote cutaneous metastasis from male breast carcinoma.
Yan et al., Wuhan, China. In Int J Dermatol, 2007
Laboratory tests showed normal plasma alpha-l-fucosidase (AFU) and alpha-fetoprotein (AFP) and a carcinoembryonic antigen (CEA) level of 145.9 microg/L.
Proteins of the cauda epididymal fluid associated with fertility of mature dairy bulls.
Killian et al., United States. In J Androl, 2006
However, the amount of alpha-L-fucosidase 2 and cathepsin D was 2.3- and 2.4-fold greater (P < .05) in high-fertility than in low-fertility bulls, respectively.
Purification and characterization of human seminal plasma alpha-L-fucosidase.
Bean et al., Bethlehem, United States. In Mol Hum Reprod, 2002
Human seminal plasma alpha-L-fucosidase (EC 3.2.1.51)
Linkage studies of cholestasis familiaris groenlandica/Byler-like disease with polymorphic protein and blood group markers.
Nielsen et al., Copenhagen, Denmark. In Hum Hered, 1993
The following markers were nonpolymorphic in this material: ADA, AK1, ALAD, APOA4, APOH, BF, C3, BCHE, CHE2, CO, ESD, FUCA2, F13A1, F13B, KEL, LE, FUT1, LU, PEPD, PGD, PGP, PLG, FUT2, SOD1 and TF.
Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2.
Wakui et al., Okayama, Japan. In Am J Med Genet, 1991
Gene-dosage and in situ hybridization study of plasminogen (PLG) and alpha-L-fucosidase 2 (FUCA2) was performed on two patients with a small deletion of the distal long arm of chromosome 6, to define the structural abnormality more precisely.
Plasma alpha-L-fucosidase activity and the risk of borderline epithelial ovarian tumors.
Holmes et al., Boston, United States. In Cancer Res, 1990
These results suggest that for most women plasma alpha-L-fucosidase activity has little or no bearing on the risk of borderline ovarian tumors.
An alpha-fucosidase pseudogene on human chromosome 2.
Welch et al., In Hum Genet, 1987
No hybridization to the FUCA2 locus on chromosome 6 was observed.
alpha-L-Fucosidase in the reproductive organs and seminal plasma of the bull.
Vanha-Perttula et al., In Biochim Biophys Acta, 1986
Gel filtration at pH 7.0 revealed two alpha-L-fucosidases (alpha-L-fucosidase I and alpha-L-fucosidase II) in most reproductive tissues, but seminal plasma, spermatozoa and epididymal cauda contained only form I. Fractionation at basic pH (pH 8.5) resulted in the elution of alpha-L-fucosidase as form II. Some differences were encountered in pH profiles and thermal stabilities of the two enzyme forms and they showed additional polymorphism after chromatofocusing.
Homozygosity for the variant alpha-L-fucosidase trait and mucolipidosis III.
Cardo et al., In Hum Genet, 1984
The thermostability curves for the plasma alpha-L-fucosidase from these patients and the plasma alpha-L-fucosidase of the parents of one of them, are discussed to support the suggestion that they are homozygous for the autosomal recessive variant alpha-L-fucosidase trait.
Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system.
Nielsen et al., In Clin Genet, 1984
Plasma fucosidase (FUCA2) was examined by means of a technique using p-nitrophenyl-alpha-L-fucopyranoside as substrate.
pH-dependent association-dissociation of high and low activity plasma alpha-L-fucosidase.
Leroy et al., In Hum Genet, 1980
Population and family studies have confirmed the existence of a plasma alpha-L-fucosidase polymorphism in humans and the autosomal recessive inheritance of the low activity trait.
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