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Pleiomorphic adenoma gene-like 2

PLAGL2, Pleomorphic Adenoma Gene Like 2
Pleiomorphic adenoma gene-like 2 is a zinc-finger protein that recognizes DNA and/or RNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PLAG1, CAN, PLAGL1, SP-C, V1a
Papers on PLAGL2
miR-218-5p inhibits the stem cell properties and invasive ability of the A2B5+CD133- subgroup of human glioma stem cells.
Du et al., Suzhou, China. In Oncol Rep, Feb 2016
Immunofluorescence staining and qRT-PCR showed that miR-218-5p reduced stem cell marker (A2B5, nestin, PLAGL2, ALDH1 and Sox2) expression compared with the controls; however, immunofluorescence staining analysis showed that upregulation of miR-218-5p expression led to no difference in CD133 expression.
Expression of lung surfactant proteins SP-B and SP-C and their modulating factors in fetal lung of FGR rats.
Chai et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, Feb 2015
This study investigated the expression of lung surfactant proteins SP-B and SP-C, and their modulating factors TTF-1 and PLAGL2 in the fetal lung of rats with fetal growth restriction (FGR).
Morphological and molecular evidence of three species of pikes Esox spp. (Actinopterygii, Esocidae) in France, including the description of a new species.
Keith et al., Paris, France. In C R Biol, 2014
This integrative taxonomy study of French pikes compares morphological characters and molecular sequence data (mitochondrial COI and nuclear Plagl2 genes).
PLAGL2 regulates actin cytoskeletal architecture and cell migration.
Senga et al., Nagoya, Japan. In Carcinogenesis, 2014
Pleomorphic adenoma gene like-2 (PLAGL2), a member of the PLAG gene family, is a C2H2 zinc finger transcriptional factor that is involved in cellular transformation and apoptosis.
The role of pleomorphic adenoma gene-like 2 in gastrointestinal cancer development, progression, and prognosis.
Wang et al., Shenyang, China. In Int J Clin Exp Pathol, 2013
Numerous previous studies have revealed that pleomorphic adenoma gene-like 2 (PLAGL2) is a transcription factor that is active in cancer progression.
Expression of regulatory platelet microRNAs in patients with sickle cell disease.
Gladwin et al., Pittsburgh, United States. In Plos One, 2012
A combinatorial approach using Meg01 mRNA expression profiles following miR-1225-3p overexpression, a computational prediction analysis of miRNA target sequences and a previously published set of differentially expressed platelet transcripts from SCD patients, identified three novel platelet mRNA targets: PBXIP1, PLAGL2 and PHF20L1.
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.
Gold et al., United States. In Int J Cancer, 2012
Three of 7 human genes found showed translation of their proteins during serial propagation in vivo or in vitro for years; namely, CD74, CXCR4 and PLAGL2, each implicated with malignancy or glioblastoma.
Phylogenetic relationships and estimation of divergence times among Sisoridae catfishes.
He et al., Wuhan, China. In Sci China Life Sci, 2012
Nineteen taxa representing 10 genera of Sisoridae were subjected to phylogenetic analyses of sequence data for the nuclear genes Plagl2 and ADNP and the mitochondrial gene cytochrome b.
Pleomorphic adenoma gene-like 2 regulates expression of the p53 family member, p73, and induces cell cycle block and apoptosis in human promonocytic U937 cells.
Gauss et al., Bozeman, United States. In Apoptosis, 2012
PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells.
Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: confirmatory and novel results in early and late sepsis.
Nanduri et al., United States. In Bmc Genomics, 2011
CONCLUSIONS: Transcriptional regulators like PLAGL2, EBF1, TCF7, KLF10 and SBNO2, previously not described in sepsis, are differentially expressed at early and late time points.
Pleiomorphic adenoma gene-like 2 expression is associated with the development of lung adenocarcinoma and emphysema.
Weissler et al., Plano, United States. In Lung Cancer, 2011
expression is associated with the development of lung adenocarcinoma and emphysema
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
DePinho et al., Boston, United States. In Cancer Cell, 2010
Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling
A multipronged approach to the identification and study of an important oncogene in GBM.
Kornblum, Los Angeles, United States. In Cancer Cell, 2010
In this issue of Cancer Cell, Zheng et al. provide strong evidence that PLAGL2 serves as an oncogene in GBM.
Modulation of PLAGL2 transactivation by positive cofactor 2 (PC2), a component of the ARC/Mediator complex.
Gauss et al., Bozeman, United States. In Gene, 2010
The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation.
PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity.
Weissler et al., Dallas, United States. In Am J Physiol Lung Cell Mol Physiol, 2009
Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells.
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Shivdasani et al., Leuven, Belgium. In Cell Metab, 2007
PlagL2 regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome.
PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review).
Van de Ven et al., Leuven, Belgium. In Int J Oncol, 2007
PLAG1 encodes a developmentally regulated, SUMOylated and phosphorylated zinc finger transcription factor, recognizes a specific bipartite DNA consensus sequence regulating expression of a spectrum of target genes, and has two structurally related family members, i.e. the PLAGL1 and PLAGL2 gene.
LOT1 (ZAC1/PLAGL1) and its family members: mechanisms and functions.
Abdollahi, Philadelphia, United States. In J Cell Physiol, 2007
The other members in this group include PLAG1 and PLAGL2, which share high homology with each other and with LOT1, particularly in their zinc-finger amino-terminal region.
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