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Pleiomorphic adenoma gene-like 1

PLAGL1, Zac1, ZAC, LOT1
This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010] (from NCBI)
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Top mentioned proteins: CAN, Insulin-Like Growth Factor II, p53, HAD, Peg3
Papers on PLAGL1
Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
New
Mao et al., Nantong, China. In Reprod Sci, Feb 2016
Moreover, HOXC8 knockdown increased the expression of ZAC1.
Treatment evolution for metastatic castration-resistant prostate cancer with recent introduction of novel agents: retrospective analysis of real-world data.
New
Mehra et al., United States. In Cancer Med, Jan 2016
Regimen analyses for first line of therapy (LOT1), second line of therapy, and beyond were performed among cohorts based on year of first mCRPC drug usage.
Exercise-associated DNA methylation change in skeletal muscle and the importance of imprinted genes: a bioinformatics meta-analysis.
Review
New
Brown, In Br J Sports Med, Dec 2015
RESULTS: Six imprinted loci (RB1, MEG3, UBE3A, PLAGL1, SGCE, INS) were important for muscle gene networks, while meta-analysis uncovered five exercise-associated imprinted loci (KCNQ1, MEG3, GRB10, L3MBTL1, PLAGL1).
The Frequency of Methylation Abnormalities Among Estonian Patients Selected by Clinical Diagnostic Scoring Systems for Silver-Russell Syndrome and Beckwith-Wiedemann Syndrome.
New
Õunap et al., Tartu, Estonia. In Genet Test Mol Biomarkers, Dec 2015
An unexpected hypomethylation of the PLAGL1 (6q24) and IGF2R (6q25) genes in the patient with the highest BWS scoring was found.
Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
New
Shan et al., Guangzhou, China. In Metabolism, Dec 2015
Expressions of transcription factor MEF2A, -2C, -2D and Zac1 were significantly up-regulated in MIF-treated neonatal mouse ventricular cardiomyocytes (NMVCs), and markedly reduced in the diabetic myocardium.
Elevated levels of ZAC1 disrupt neurogenesis and promote rapid in vivo reprogramming.
New
Holmberg et al., Stockholm, Sweden. In Stem Cell Res, Dec 2015
UNASSIGNED: The zinc finger transcription factor Zac1 is expressed in dividing progenitors of the nervous system with expression levels negatively controlled by genomic imprinting.
Zac1 Regulates the Differentiation and Migration of Neocortical Neurons via Pac1.
New
Schuurmans et al., Lyon, France. In J Neurosci, Oct 2015
To test whether growth-associated genes influence neural lineage progression, we focused on the maternally imprinted gene Zac1.
Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism.
Review
New
Spengler et al., München, Germany. In World J Biol Chem, Sep 2015
Genetic defects in TNDM1 comprise uniparental isodisomy of chromosome 6, duplication of the minimal TNDM1 locus at 6q24, or relaxation of genomically imprinted ZAC1/HYMAI.
Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.
Review
New
Ferdinandy et al., Chieti, Italy. In Int J Cardiol, Aug 2015
Genes critical for signaling pathways in cardioprotection include protectomiRs (e.g., microRNA 125b*), ZAC1 transcription factor, pro-inflammatory genes such as cycloxygenase (COX)-2 and inducible nitric oxide synthase (iNOS), antioxidant enzymes such as hemoxygenase (HO)-1, extracellular and manganese superoxidase dismutases (ec-SOD and Mg-SOD), heat shock proteins (HSPs), growth factors such as insulin like growth factor (IGF)-1 and hepatocyte growth factor (HGF), antiapoptotic proteins such as Bcl-2 and Bcl-xL, pro-apoptotic proteins such as FasL, Bcl-2, Bax, caspase-3 and p53, and proangiogenic genes such as TGFbeta, sphingosine kinase 1 (SPK1), and PI3K-Akt.
Imprinted Zac1 in neural stem cells.
Review
New
Hoffmann et al., München, Germany. In World J Stem Cells, Apr 2015
Moreover, imprinted genes like the transcriptional regulator Zac1 can fine tune neuronal vs astroglial differentiation of NSCs.
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape.
Kelsey et al., Clermont-Ferrand, France. In Genome Biol, 2014
We generate a mouse model in which transcription across the Zac1/Plagl1 locus is abrogated in oocytes, resulting in failure of DNA methylation establishment at all CpGs of this locus.
mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs.
Tian et al., United States. In Sci Rep, 2014
Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, GNAS, MEG3, DGAT1, ASCL2, NNAT, and NAP1L5); or constantly low (DIRAS3, IGF2, H19 and RTL1).
Silver nanoparticles cause complications in pregnant mice.
Kim et al., Seoul, South Korea. In Int J Nanomedicine, 2014
AgNPs exposure increased the meiotic progression of female germ cells in the fetal mouse ovaries, and maternal AgNP exposure significantly disrupted imprinted gene expression in 15.5 dpc embryos and placentas, such as Ascl2, Snrpn, Kcnq1ot1, Peg3, Zac1, H19, Igf2r, and Igf2; DNA methylation studies revealed that AgNPs exposure significantly altered the methylation levels of differentially methylated regions of Zac1.
Opposing Effects of Zac1 and Curcumin on AP-1-Regulated Expressions of S100A7.
Wang et al., Taipei, Taiwan. In Plos One, 2014
ZAC, an encoding gene mapped at chromosome 6q24-q25 within PSORS1, was previously found over-expressed in the lower compartment of the hyperplastic epidermis in psoriatic lesions.
Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.
Review
Klibanski et al., Boston, United States. In Mol Cell Endocrinol, 2014
The p53 group includes MEG3, MGMT, PLAGL1, RASSF1, RASSF3 and SOCS1.
Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
GeneRIF
Spengler et al., München, Germany. In Mol Cell Biol, 2012
identified the guanine nucleotide exchange factor Rasgrf1 as a direct Zac1/Plagl1 target gene in beta cells
A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.
GeneRIF
Huang et al., Taipei, Taiwan. In Int J Biochem Cell Biol, 2012
This work indicates that Zac1 functions are regulated, at least in part, via non-covalent interactions with SUMO-1 for the induction of p21, which is important for the modulation of apoptosis.
Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells.
GeneRIF
Huang et al., Taipei, Taiwan. In Exp Cell Res, 2012
Zac1 is able to interact directly with the Sp1-responsive element in the p21(WAF1/Cip1) gene promoter.
Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.
GeneRIF
Husgafvel-Pursiainen et al., Vilnius, Lithuania. In Cancer Genet, 2011
Our study suggests the involvement of the imprinted ZAC gene in the pathogenesis of pheochromocytoma.
Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum.
GeneRIF
Hawkes et al., Calgary, Canada. In Neural Dev, 2010
The Zac1 is a critical regulator of normal cerebellar development, adding a new transcriptional regulator to the growing list of factors involved in generating neuronal diversity in the developing cerebellum.
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