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JMJD7-PLA2G4B readthrough

PLA2G4B, cPLA2beta, phospholipase A2, group IVB
This gene transcribes naturally-occurring mRNAs that are read-through products of the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (PLA2G4B) genes. These read-through products contain in-frame segments from both genes but a function has yet to be determined for the predicted fusion proteins, which contain a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: phospholipase A2, ACID, PLA2, OUT, SET
Papers on PLA2G4B
Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population.
Leppert et al., Salt Lake City, United States. In Mol Autism, 2013
Three variants, in the RAB11FIP5, ABP1, and JMJD7-PLA2G4B genes, each were observed in a single case and not in any controls.
Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer.
Mehta et al., Little Rock, United States. In Plos One, 2010
Transcriptome of Olr1 KO mice also revealed inhibition of de novo lipogenesis, rate-limiting enzymes fatty acid synthase (Fasn), stearoyl-CoA desaturase (Scd1) and ELOVL family member 6 (Elovl6), as well as lipolytic phospholipase A2 group IVB (Pla2g4b).
Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.
Gelb et al., Seattle, United States. In J Biol Chem, 2010
The cytosolic (group IV) phospholipase A(2) (cPLA(2)s) family contains six members.
Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
GeneRIF
Yang et al., Taiwan. In Am J Pathol, 2010
TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses
Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition.
Kim et al., Bethesda, United States. In J Pathol, 2009
Computational analyses using miRBase Targets have identified PLA2G4B, a phospholipase implicated in parturition, as a putative target of miR-338.
Properties of the Group IV phospholipase A2 family.
Review
Leslie et al., Denver, United States. In Prog Lipid Res, 2006
The Group IV phospholipase A2 family is comprised of six intracellular enzymes commonly called cytosolic phospholipase A2 (cPLA2) alpha, cPLA2beta, cPLA2gamma, cPLA2delta, cPLA2epsilon and cPLA2zeta.
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
Leslie et al., Denver, United States. In J Biol Chem, 2006
In this study, we identify the principal splice variant of human cytosolic phospholipase A(2)beta (cPLA(2)beta) (also known as Group IVB cPLA(2)) present in cells.
A family based study of the genetic association between the PLA2G4D gene and schizophrenia.
Wei et al., Changchun, China. In Prostaglandins Leukot Essent Fatty Acids, 2005
The conditioning on allele (COA) test revealed a weak association for the rs2459692-PLA2G4A combination (chi(2) = 6.03, df = 2, P = 0.049), the rs2459692-PLA2G4B combination (chi(2) = 7.16, df = 3, P = 0.028) and the rs4924618-PLA2G4C combination (chi(2) = 7.01, df = 2, P = 0.03), whereas the conditioning on genotype (COG) test showed a weak association only for the rs4924618-PLA2G4C combination (chi(2) = 8.52, df = 3, P = 0.036).
Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia.
Wei et al., Changchun, China. In Am J Med Genet B Neuropsychiatr Genet, 2005
The present study detected three single nucleotide polymorphisms (SNPs), BanISNP at the PLA2G4A locus, rs1648833 at the PLA2G4B locus, and rs1549637 at the PLA2G4C locus, to investigate a genetic association between the cytosolic PLA2 (cPLA2) genes and schizophrenia.
Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability.
O'Donovan et al., Cardiff, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2004
Both were phospholipase genes, phospholipase C beta 2 (PLCB2) and phospholipase A2, group IVB (cytosolic; PLA2G4B).
Regulatory mechanism and physiological role of cytosolic phospholipase A2.
Review
Shimizu et al., Chiba, Japan. In Biol Pharm Bull, 2004
Now novel three paralogs, cPLA2beta, cPLA2gamma, and cPLA2delta, have been identified in humans.
Specific differential expression of phospholipase A2 subtypes in rat cerebellum.
Ito et al., Wako, Japan. In J Neurocytol, 2004
Two Ca2+-dependent cytosolic subtypes (cPLA2alpha and cPLA2beta), one Ca2+-independent cytosolic subtype (iPLA2), and two secretory subtypes (sPLA2IIA and sPLA2V) were detected in the cerebellum.
Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
GeneRIF
Rubin et al., Toronto, Canada. In J Biol Chem, 2002
circulating human neutrophils express groups V and X sPLA(2) (GV and GX sPLA(2)) mRNA and contain GV and GX sPLA(2) proteins, whereas GIB, GIIA, GIID, GIIE, GIIF, GIII, and GXII sPLA(2)s are undetectable
Molecular characterization of cytosolic phospholipase A2-beta.
Kriz et al., Cambridge, United States. In J Biol Chem, 1999
We have isolated a cDNA encoding a 1012-amino acid polypeptide cPLA2-beta, that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain.
Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2.
Sharp et al., Indianapolis, United States. In J Biol Chem, 1999
We propose to call these cPLA2beta (114 kDa) and cPLA2gamma (61 kDa), giving the name cPLA2alpha to the well known 85-kDa enzyme.
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