GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Phospholipase A2, group IB
PLA2, sPLA2
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986 [PubMed 3028739]) .[supplied by OMIM, Mar 2008] (from
NCBI)
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Papers on
PLA2
A novel non-toxic inhibitor of the activation of NADPH oxidase (NOX2) reduces reactive oxygen species production in mouse lung.
New
United States. In J Pharmacol Exp Ther, 08 Apr 2013
1-Hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33), a fluorinated phospholipid analogue that inhibits the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx6), is a potential agent for prevention of lung oxidative stress.
Neutralization of Apis mellifera Bee Venom Activities by Suramin.
New
Rio de Janeiro, Brazil. In Toxicon, 05 Apr 2013
Suramin markedly inhibited the PLA2 activity in a concentration-dependent way (1-30 μM).
Therapeutic Options to Reduce Lp-PLA2 Levels and the Potential Impact on Vascular Risk Reduction.
New
Philadelphia, United States. In Curr Treat Options Cardiovasc Med, 03 Apr 2013
OPINION STATEMENT: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme involved in the metabolism of Low-density lipoprotein (LDL) to pro-inflammatory mediators.
Molecular Phylogeny and Evolution of the Proteins Encoded by Coleoid (Cuttlefish, Octopus, and Squid) Posterior Venom Glands.
New
Australia. In J Mol Evol, 02 Apr 2013
In this study, we report for the first time a detailed evaluation of the phylogenetic history and molecular evolution of the major coleoid toxins: CAP, carboxypeptidase, chitinase, metalloprotease GON-domain, hyaluronidase, pacifastin, PLA2, SE-cephalotoxin and serine proteases, with the carboxypeptidase and GON-domain documented for the first time in the coleoid venom arsenal.
Key role of group v secreted phospholipase A2 in th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
New
Seattle, United States. In Plos One, Dec 2012
The impairment in eicosanoid generation and dendritic cell activation in sPLA2-V mice diminishes Th2 cytokine responses in the airways.
Phospholipase A₂ activities in skin physiology and pathology.
Review
New
Jerusalem, Israel. In Eur J Pharmacol, Oct 2012
Instead, the upstream control of phospholipase A2 (PLA2) enzymatic activity, which hydrolyzes cell membrane phospholipids to initiate the eicosanoid production, has been considered for inhibiting eicosanoid activation while maintaining the intricate balance needed for their homeostatic functions.
Mechanism of Pdia3-dependent 1α,25-dihydroxy vitamin D3 signaling in musculoskeletal cells.
Review
New
Atlanta, United States. In Steroids, Aug 2012
The data demonstrate the requirement for Pdia3 in 1,25(OH)2D3 induced phospholipase A2 (PLA2) and protein kinase C (PKC) activation and downstream responses.
A novel bacterial resistance mechanism against human group IIA-secreted phospholipase A2: role of Streptococcus pyogenes sortase A.
GeneRIF
Lund, Sweden. In J Immunol, 2012
Human sPLA2-IIA contributes to the host defense against serious experimental S. pyogenes infection, providing a novel example of a bacterial resistance mechanism involved in protection against S. pyogenes infections in humans.
Molecular link mechanisms between inflammation and cancer.
Review
Campinas, Brazil. In Curr Pharm Des, 2011
These cells produce a variety of cytotoxic mediators such as reactive oxygen and nitrogen species (ROS and RNS respectively), serine and cysteine proteases, membrane perforating agents, matrix metalloproteinase (MMP), tumor necrosis factor α (TNFα), interleukins (IL-1, IL-6, IL-8), interferons (IFNs) and enzymes, as cyclooxygenase-2 (COX-2), lipooxygenase-5 (LOX-5) and phospholipase A2 (PLA2), which activate or are activated by transcription factors as nuclear factor κB (NF-κB) and signal transducers and activators of transcription-3 (STAT3).
[Secretory phospholipase A2 and its role in oxidative stress and inflammation].
Review
Warsaw, Poland. In Postepy Biochem, 2011
Phospholipase A2 (EC 3.1.1.4,
Group 1B phospholipase A₂ deficiency protects against diet-induced hyperlipidemia in mice.
GeneRIF
Cincinnati, United States. In J Lipid Res, 2011
inhibition of Pla2g1b protects against diet-induced hyperlipidemia
Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)α, not Ca(2+)-independent PLA(2)β, to lipid mobilization in proximal mast cells and distal fibroblasts.
GeneRIF
Tokyo, Japan. In J Biol Chem, 2011
Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)alpha, not Ca(2+)-independent PLA(2)beta, to lipid mobilization in proximal mast cells and distal fibroblasts.
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis.
Impact
Paris, France. In Jama, 2011
and ITGB3 PLA2 carriage (adjusted OR, 0.52; 95% CI, 0.28-0.95).
Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes.
GeneRIF
Suita, Japan. In J Neurosci, 2011
neuroaxonal dystrophy in iPLA2beta deficiency is thought to be caused by two types of pathomechanism, which are associated with insufficient remodeling of the mitochondrial inner membrane and presynaptic membrane of axon terminals
Phospholipase A2 group IIA expression correlates with prolonged survival in gastric cancer.
GeneRIF
Beijing, China. In Histopathology, 2011
PLA2G2A may predict survival and might be a potential biomarker for early detection and individualized therapy.
[Biochemical markers in assessment of severity and prognosis of acute pancreatitis].
Review
Zagreb, Croatia. In Lijec Vjesn, 2008
These parameters include trypsinogen activation peptide (TAP), C-reactive protein (CRP, tripsinogen-2, procalcitonin, phospholipase-A2 (PLA2), carboxypeptidase activation peptide (CAPAP) and interleukin-6 and 8 (IL-6, IL-8).
Biochemistry and physiology of mammalian secreted phospholipases A2.
Review
Impact
Antibes, France. In Annu Rev Biochem, 2007
The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity.
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures.
Impact
Padova, Italy. In Science, 2006
Snake presynaptic phospholipase A2 neurotoxins (SPANs) paralyze the neuromuscular junction (NMJ).
Deletion of cytosolic phospholipase A2 promotes striated muscle growth.
Impact
Boston, United States. In Nat Med, 2003
Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular homeostasis, inflammation and tumorigenesis.
The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing.
Review
Impact
San Diego, United States. In Annu Rev Pharmacol Toxicol, 2001
Intrathecal phospholipase A2 (PLA2) and cyclooxygenase-2 (COX-2), but not COX-1, inhibitors attenuate facilitated pain states generated by peripheral injury/inflammation and by direct activation of spinal glutamate and substance P receptors.
