Secreted phospholipase A2 and mast cells.
Tokyo, Japan. In Allergol Int, Jan 2015
Among the PLA2 superfamily, secreted PLA2 (sPLA2) enzymes comprise the largest subfamily that includes 11 isoforms with a conserved His-Asp catalytic dyad.
HDL in infectious diseases and sepsis.
Cinisello Balsamo, Italy. In Handb Exp Pharmacol, Dec 2014
More importantly, endotoxemia modulates HDL composition and size: phospholipids are reduced as well as apolipoprotein (apo) A-I, while serum amyloid A (SAA) and secretory phospholipase A2 (sPLA2) dramatically increase, and, although the total HDL particle number does not change, a significant decrease in the number of small- and medium-size particles is observed.
Hepatoprotective Triterpene Saponins from the Roots of Glycyrrhiza inflata.
Nanjing, China. In Molecules, Dec 2014
In addition, compounds 2-4, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 μM, 3.6 μM, 16.9 μM, 27.1 μM, 32.2 μM and 9.3 μM, respectively, which might be involved in the regulation of the hepatoprotective activities observed.