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POU class 2 homeobox 3

PlA1, POU transcription factor, Skn-1a
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: PLA2, CD45, CAN, HAD, ACID
Papers on PlA1
Isolation of a Hypomorphic skn-1 Allele that does not Require a Balancer for Maintenance.
New
Choe et al., United States. In G3 (bethesda), Jan 2016
UNASSIGNED: In Caenorhabditis elegans, the transcription factor SKN-1 has emerged as a central coordinator of stress responses and longevity increasing the need for genetic tools to study its regulation and function.
Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).
New
Chi et al., Austin, United States. In Biochem Biophys Res Commun, Jan 2016
As a member of the POU transcription factor family, HNF1α exerts its gene regulatory function through various molecular interactions; however, there is a paucity of knowledge in their functional complex formation.
Emissions of Nanoparticles and Gaseous Material from 3D Printer Operation.
New
Tsai et al., Seoul, South Korea. In Environ Sci Technol, Nov 2015
One ABS and two PLA (PLA1 and PLA2) cartridges were tested three times.
Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.
New
Wohland et al., Edinburgh, United Kingdom. In Embo Rep, Sep 2015
Embryonic stem cell (ESC) identity is orchestrated by co-operativity between the transcription factors (TFs) Sox2 and the class V POU-TF Oct4 at composite Sox/Oct motifs.
Association of platelet glycoprotein receptor alpha2beta1 integrin and glycoprotein IIIa gene polymorphisms with diabetic retinopathy: evidence from 3007 subjects.
Review
New
Sun et al., Hefei, China. In Curr Eye Res, May 2015
Meta-analysis was performed for ITGA2 gene BgI II polymorphism (7 studies including 758 cases and 570 controls) and ITGB3 gene PlA1/A2 polymorphism (4 studies including 1047 cases and 861 controls).
The HRASLS (PLA/AT) subfamily of enzymes.
Review
Duncan et al., Waterloo, Canada. In J Biomed Sci, 2014
All HRASLS family members possess in vitro phospholipid metabolizing abilities including phospholipase A1/2 (PLA1/2) activities and O-acyltransferase activities for the remodeling of glycerophospholipid acyl chains, as well as N-acyltransferase activities for the production of N-acylphosphatidylethanolamines.
Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity.
Satchell et al., Chicago, United States. In Nat Commun, 2014
ABH binds with high affinity to phosphatidylinositol-3-phosphate (PtdIns3P) and cleaves the fatty acid in PtdIns3P at the sn1 position in vitro making it the first PtdIns3P-specific phospholipase A1 (PLA1).
POU transcription factors in melanocytes and melanoma.
Review
Berking et al., München, Germany. In Eur J Cell Biol, 2014
Here, the POU transcription factor family and its role in melanocytic transformation and melanoma are reviewed.
The PlA1/A2 polymorphism of glycoprotein IIIa as a risk factor for stroke: a systematic review and meta-analysis.
Review
Ferro et al., London, United Kingdom. In Plos One, 2013
BACKGROUND: The PlA1/A2 polymorphism of glycoprotein IIIa (GPIIIa) has been reported to be associated with risk of stroke in some studies, although other studies suggest no such association.
Plant phospholipase A: advances in molecular biology, biochemistry, and cellular function.
Review
Weselake et al., In Biomol Concepts, 2013
Plant PLAs can be grouped into three families, PLA1, PLA2, and patatin-like PLA, that catalyze the hydrolysis of acyl groups from the sn-1 and/or sn-2 position.
Relation between the expression levels of the POU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation.
GeneRIF
Sawamura et al., In J Dermatol Sci, 2010
It is possible that Skn-1a and the related isoforms have different functions in keratinocyte differentiation and proliferation.
Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.
GeneRIF
Candi et al., Roma, Italy. In Biochem Biophys Res Commun, 2010
the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene promoter or through an indirect interaction.
Transcription factor human Skn-1a enhances replication of human papillomavirus DNA through the direct binding to two sites near the viral replication origin.
GeneRIF
Kanda et al., Tokyo, Japan. In Febs J, 2008
Skn-1a enhanced the transient replication of a plasmid containing the HPV16 replication origin in HEK293 cells when co-transfected with a plasmid expressing E1 and E2.
Identification of Skn-1n, a splice variant induced by high calcium concentration and specifically expressed in normal human keratinocytes.
GeneRIF
Sawamura et al., In J Invest Dermatol, 2008
splice variant induced in keratinocytes by high calcium
Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.
GeneRIF
Sedlacek et al., Kiel, Germany. In J Invest Dermatol, 2007
Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes.
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
Impact
Smith et al., Edinburgh, United Kingdom. In Nat Genet, 2000
The POU transcription factor Oct-3/4 (encoded by Pou5f1) is a candidate regulator in pluripotent and germline cells and is essential for the initial formation of a pluripotent founder cell population in the mammalian embryo.
Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness.
Impact
Noda et al., Tokyo, Japan. In Science, 1999
DFN3, an X chromosome-linked nonsyndromic mixed deafness, is caused by mutations in the BRN-4 gene, which encodes a POU transcription factor.
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
Impact
Smith et al., Edinburgh, United Kingdom. In Cell, 1998
Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ cells.
The POU factor Oct-6 and Schwann cell differentiation.
Impact
Meijer et al., Rotterdam, Netherlands. In Science, 1996
The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation.
Expression and activity of the POU transcription factor SCIP.
Impact
Lemke et al., Los Angeles, United States. In Science, 1990
POU proteins have been shown to transcriptionally active cell-specific genes and to participate in the determination of cell fate.
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