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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Family with sequence similarity 65, member B

PL48, C6ORF32, KIAA0386
The protein encoded by this gene stimulates the formation of a non-mitotic multinucleate syncytium from proliferative cytotrophoblasts during trophoblast differentiation. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Myogenin, Insulin-Like Growth Factor Binding Protein 1, TGF-beta3, GAX, TGF-beta
Papers on PL48
PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.
Waxman et al., Boston, United States. In Mol Cancer, 2009
PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low.
Identification and characterization of a novel neural cell adhesion molecule (NCAM)-associated protein from quail myoblasts: relationship to myotube formation and induction of neurite-like protrusions.
Kim et al., Kyoto, Japan. In Differentiation, 2008
MYONAP shares homology with PL48 in human cytotrophoblasts and KIAA0386 in human brain.
C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia.
Gussoni et al., Boston, United States. In Dev Biol, 2007
C6ORF32 is a novel protein likely to play multiple functions, including promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation
Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal.
Li et al., Edmonton, Canada. In Curr Protein Pept Sci, 2001
Differential techniques have revealed several novel genes and peptides involved in trophoblast development including PL74/gdf15/MIC-1, a TGFbeta family cytokine that controls apoptosis and differentiation, PL48, a new serine-threonine protein kinase, serum and glucocorticoid-induced kinase, PBK-1, a tunicamycin-responsive gene, a cathepsin D-like gene (DAP-1) and hypoxia- regulated genes HRF-1,2,6,8 and HIF-1alpha, HIF-1beta, and hEPAS-1.
Functional regulation of human trophoblast differentiation.
Li et al., Edmonton, Canada. In J Reprod Immunol, 1998
Term villous cytotrophoblasts are stimulated to form a syncytium by EGF, GM-CSF, CSF-1, dexamethasone, hCG, fibronectin, collagen I and PL48 and inhibited by TGFbeta1.
PL48: a novel gene associated with cytotrophoblast and lineage-specific HL-60 cell differentiation.
Morrish et al., Edmonton, Canada. In Gene, 1997
The cDNA for a novel gene, PL48, isolated by subtractive hybridization between undifferentiated human term cytotrophoblast and differentiating cytotrophoblast, has been cloned and sequenced.
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