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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Prokineticin receptor 2

PKR2, PROKR2, prokineticin receptor 2
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PKR2
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.
Brue et al., Marseille, France. In J Clin Endocrinol Metab, 2012
We report PROKR2 variants in congenital hypopituitarism with pituitary stalk interruption, suggesting a potential role of the prokineticin pathway in pituitary development.
Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.
Alfaidy et al., Grenoble, France. In Cell Mol Life Sci, 2012
hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors
Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia.
Pitteloud et al., Helsinki, Finland. In J Clin Endocrinol Metab, 2012
genetic association studies in 103 patients from US and UK: Mutations in PROKR2, FGFR1, or FGF8 contributed to 7.8% of patients with combined pituitary hormone deficiency or septo-optic dysplasia. Data suggest genetic overlap with Kallmann syndrome.
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.
Borrego et al., Sevilla, Spain. In Plos One, 2010
Findings, together with the detection of sequence variants in PROKR1, PROK1 and PROKR2 genes associated to HSCR and, in some cases in combination with RET or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR.
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.
Niv et al., Jerusalem, Israel. In Plos One, 2010
The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2.
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