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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prokineticin receptor 2

PKR2, PROKR2, prokineticin receptor 2
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PK2, PKR1, FGFR1, Kms, Gonadotropin-Releasing Hormone
Papers on PKR2
Snapin interacts with G-protein coupled receptor PKR2.
Li et al., Changsha, China. In Biochem Biophys Res Commun, Feb 2016
Mutations in Prokineticin receptor 2 (PKR2), a G-protein-coupled receptor, have been identified in patients with Kallmann syndrome and/or idiopathic hypogonadotropic hypogonadism, characterized by delayed puberty and infertility.
Prokineticins in central and peripheral control of human reproduction.
Alfaidy et al., In Horm Mol Biol Clin Investig, Dec 2015
PROKs activate two G-protein linked receptors (prokineticin receptor 1 and 2, PROKR1 and PROKR2).
Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism: evidence for the involvement of an alternatively spliced isoform.
Lemos et al., Covilhã, Portugal. In Fertil Steril, Nov 2015
Oligogenic inheritance (FGFR1/CHD7/PROKR2) was found in one patient.
Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
Sbiera et al., Würzburg, Germany. In Horm Cancer, Nov 2015
EG-VEGF has antiapoptotic, mitogenic, and chemoattractive properties mediated via the two G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2).
Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer.
Yamaguchi et al., Fukui, Japan. In Oncotarget, Nov 2015
According to recent molecular biological studies, signaling through transmembrane Prokineticin-Receptor2(PK-R2) is likely involved in the ability of tumor cell to invade.
Expanding the Spectrum of Founder Mutations Causing Isolated Gonadotropin-Releasing Hormone Deficiency.
Crowley et al., Caen, France. In J Clin Endocrinol Metab, Oct 2015
However, somewhat paradoxically, four IGD genes (GNRH1, TAC3, PROKR2, and GNRHR) have been shown to harbor LoF founder mutations that are shared by multiple unrelated individuals.
Can prokineticin prevent obesity and insulin resistance?
Nebigil et al., Illkirch-Graffenstaden, France. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
They act on the G protein-coupled receptors PKR1 and PKR2.
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.
Negri et al., Ferrara, Italy. In Sci Rep, 2014
Analyzing primary cortical cultures (CNs) and cortex and hippocampus from Aβ treated rats, we found that PROK2 and its receptors PKR1 and PKR2 mRNA are up-regulated by Aβ, suggesting their potential involvement in AD.
[Congenital hypogonadotropic hypogonadism and Kallmann syndrome in males].
Young et al., Cluj-Napoca / Kolozsvár, Romania. In Presse Med, 2014
Mutations in KAL1, FGFR1/FGF8/FGF17, PROK2/PROKR2, NELF, CHD7, HS6ST1, WDR11, SEMA3A, SOX10, IL17RD2, DUSP6, SPRY4, and FLRT3 have been associated with KS but sometimes also with its milder hyposmic/normosmic CHH clinical variant.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration.
Kallmann syndrome in women: from genes to diagnosis and treatment.
Genazzani et al., Poznań, Poland. In Gynecol Endocrinol, 2013
These genes can be listed in chronological order: KAL1, FGFR1, FGF8, CHD7, PROKR2 and PROK2.
The role of hypoxia-induced genes in ovarian angiogenesis.
Yalu et al., Jerusalem, Israel. In Reprod Fertil Dev, 2012
Special emphasis is given to hypoxia-induced, luteal cell-specific expression of multiple genes (vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF-2), prokineticin receptor 2 (PK-R2), stanniocalcin 1 (STC-1) and endothelin 2 (EDN-2) that participate in the angiogenic process during CL formation.
PROKR2 variants in multiple hypopituitarism with pituitary stalk interruption.
Brue et al., Marseille, France. In J Clin Endocrinol Metab, 2012
We report PROKR2 variants in congenital hypopituitarism with pituitary stalk interruption, suggesting a potential role of the prokineticin pathway in pituitary development.
Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.
Alfaidy et al., Grenoble, France. In Cell Mol Life Sci, 2012
hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors
Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia.
Pitteloud et al., Helsinki, Finland. In J Clin Endocrinol Metab, 2012
genetic association studies in 103 patients from US and UK: Mutations in PROKR2, FGFR1, or FGF8 contributed to 7.8% of patients with combined pituitary hormone deficiency or septo-optic dysplasia. Data suggest genetic overlap with Kallmann syndrome.
The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations.
Crowley et al., Boston, United States. In Endocr Rev, 2011
Among these genes, prokineticin 2 (PROK2), and PROK2 receptor (PROKR2) have recently emerged as critical regulators of reproduction in both mice and humans.
A genetic basis for functional hypothalamic amenorrhea.
Pitteloud et al., Boston, United States. In N Engl J Med, 2011
RESULTS: Six heterozygous mutations were identified in 7 of the 55 patients with hypothalamic amenorrhea: two variants in the fibroblast growth factor receptor 1 gene FGFR1 (G260E and R756H), two in the prokineticin receptor 2 gene PROKR2 (R85H and L173R), one in the GnRH receptor gene GNRHR (R262Q), and one in the Kallmann syndrome 1 sequence gene KAL1 (V371I).
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.
Borrego et al., Sevilla, Spain. In Plos One, 2010
Findings, together with the detection of sequence variants in PROKR1, PROK1 and PROKR2 genes associated to HSCR and, in some cases in combination with RET or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR.
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.
Niv et al., Jerusalem, Israel. In Plos One, 2010
The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2.
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
Zhou et al., Irvine, United States. In Nature, 2002
Receptor for PK2 (PKR2) is abundantly expressed in major target nuclei of the SCN output pathway.
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