Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.
Ferrara, Italy. In Sci Rep, 2014
Analyzing primary cortical cultures (CNs) and cortex and hippocampus from Aβ treated rats, we found that PROK2 and its receptors PKR1 and PKR2 mRNA are up-regulated by Aβ, suggesting their potential involvement in AD.
Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system.
Roma, Italy. In Curr Opin Pharmacol, 2012
It belongs to a new family of chemokines, which activate two G-protein linked receptors (prokineticin receptor 1 and 2, PKR1 and PKR2) expressed in regions of the nervous system associated with pain and in cells participating to immuno-inflammatory responses.
Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions.
Illkirch-Graffenstaden, France. In Cardiovasc Res, 2011
Prokineticins (PK1 and PK2) are peptide hormones that exert their biological activity via two common G-protein-coupled receptors: prokineticin receptor (PKR) 1 and 2. Their physiology was originally explored mostly in the context of angiogenic actions in the reproductive tract and gut motility.
Bethesda, United States. In Unknown Journal, 2011
The prokineticins PK1 and PK2, which are mammalian homologs of Bv8, and their G-protein–coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) have been identified and linked to several biological functions such as gut motility, neurogenesis, angiogenesis, circadian rhythms, hematopoiesis, and nociception (2-4).