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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Prokineticin receptor 1

PKR1, prokineticin receptor 1
G protein-coupled receptor for prokineticin [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PKR2, PK2, V1a, vascular endothelial growth factor, PROK1
Papers using PKR1 antibodies
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
Supplier
Denison Fiona C. et al., In Human Reproduction (Oxford, England), 1998
... Prokineticin receptor 1 antibody was purchased from Lifespan Biosciences (Atlanta, GA, USA) ...
Papers on PKR1
Prokineticins in central and peripheral control of human reproduction.
New
Alfaidy et al., In Horm Mol Biol Clin Investig, Dec 2015
PROKs activate two G-protein linked receptors (prokineticin receptor 1 and 2, PROKR1 and PROKR2).
Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats.
New
Zhang et al., Wuhan, China. In Inflammation, Nov 2015
Given one of the cognate receptors of prokineticin 2, prokineticin receptor 1 (PKR1) was also significantly upregulated in orchitis as discussed in the current study, it is very likely that PK2/PKR1 signaling contribute to the development of inflammation-related testicular diseases.
Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
New
Sbiera et al., Würzburg, Germany. In Horm Cancer, Nov 2015
EG-VEGF has antiapoptotic, mitogenic, and chemoattractive properties mediated via the two G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2).
Can prokineticin prevent obesity and insulin resistance?
Review
New
Nebigil et al., Illkirch-Graffenstaden, France. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
They act on the G protein-coupled receptors PKR1 and PKR2.
PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.
New
Alfaidy et al., Grenoble, France. In Am J Physiol Endocrinol Metab, Sep 2015
EG-VEGF exerts its functions via prokineticin receptor 1 (PROKR1) and 2 (PROKR2).
PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice.
Luongo et al., Napoli, Italy. In Pharmacol Res, 2015
PKs bind two G protein coupled receptors, PKR1 and PKR2, and participate in the regulation of several biological processes, including pain sensation.
Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity.
Negri et al., Ferrara, Italy. In Sci Rep, 2014
Analyzing primary cortical cultures (CNs) and cortex and hippocampus from Aβ treated rats, we found that PROK2 and its receptors PKR1 and PKR2 mRNA are up-regulated by Aβ, suggesting their potential involvement in AD.
Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.
Nebigil et al., Illkirch-Graffenstaden, France. In Plos One, 2014
Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2.
Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model.
Negri et al., Roma, Italy. In Biomed Res Int, 2014
The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and immunomodulation.
Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats.
Irahara et al., Tokushima, Japan. In Int J Dev Neurosci, 2014
It has been reported that PK2 inhibits food intake via PKR1 and that the hypothalamic PK2 mRNA levels of adult rodents were reduced by food deprivation.
Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.
Wang et al., Shanghai, China. In Neural Regen Res, 2012
Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased.
Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.
GeneRIF
Alfaidy et al., Grenoble, France. In Cell Mol Life Sci, 2012
hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors
Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system.
Review
Lattanzi et al., Roma, Italy. In Curr Opin Pharmacol, 2012
It belongs to a new family of chemokines, which activate two G-protein linked receptors (prokineticin receptor 1 and 2, PKR1 and PKR2) expressed in regions of the nervous system associated with pain and in cells participating to immuno-inflammatory responses.
Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions.
Review
Nebigil et al., Illkirch-Graffenstaden, France. In Cardiovasc Res, 2011
Prokineticins (PK1 and PK2) are peptide hormones that exert their biological activity via two common G-protein-coupled receptors: prokineticin receptor (PKR) 1 and 2. Their physiology was originally explored mostly in the context of angiogenic actions in the reproductive tract and gut motility.
Bv8-prokineticins and their receptors: modulators of pain.
Review
Lattanzi et al., Roma, Italy. In Curr Pharm Biotechnol, 2011
Mammalian homologues of Bv8, the prokineticins PK1 and PK2, and their G-protein coupled receptors PKR1 and PKR2 have been identified and linked to several biological effects as gut motility, circadian rhythms, neurogenesis, angiogenesis and cancer progression, haematopoiesis and nociception.
N-(4-[(18)F]Fluoro-benzoyl)-N'-{2-[5-(4-fluoro-benzyl)-1-(4-methoxy-benzyl)-4,6-dioxo-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylamino]-ethyl}-guanidine
Review
Leung, Bethesda, United States. In Unknown Journal, 2011
The prokineticins PK1 and PK2, which are mammalian homologs of Bv8, and their G-protein–coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) have been identified and linked to several biological functions such as gut motility, neurogenesis, angiogenesis, circadian rhythms, hematopoiesis, and nociception (2-4).
Genetic inactivation of prokineticin receptor-1 leads to heart and kidney disorders.
GeneRIF
Nebigil et al., Illkirch-Graffenstaden, France. In Arterioscler Thromb Vasc Biol, 2011
Loss of PKR1 causes renal and cardiac structural and functional changes because of deficits in survival signaling, mitochondrial, and progenitor cell functions in found both organs.
Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.
GeneRIF
Borrego et al., Sevilla, Spain. In Plos One, 2010
Findings, together with the detection of sequence variants in PROKR1, PROK1 and PROKR2 genes associated to HSCR and, in some cases in combination with RET or GDNF mutations, provide evidence to consider them as susceptibility genes for HSCR.
The possible role of the PK1 and its receptor in the etiology of the preeclampsia.
GeneRIF
Breborowicz et al., Poznań, Poland. In Neuro Endocrinol Lett, 2010
The number of PKR1 is not reduced in preeclampsia.
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.
GeneRIF
Niv et al., Jerusalem, Israel. In Plos One, 2010
The results suggest an identical transmembrane-bundle binding site for hPKR1 and hPKR2.
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