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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic translation initiation factor 2-alpha kinase 2

PKR
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, PrP, eIF2alpha
Papers using PKR antibodies
Induction of neurites by the regulatory domain of PKCδ and ε in neural cells is counteracted by PKC catalytic activity and the RhoA pathway.
Supplier
Kahle Philipp J., In PLoS ONE, 2003
... obtained from Santa Cruz, PKCα rabbit monoclonal antibody (antigen in N-terminus) from Epitomics, TIA1 and PKR from Abcam, phospho-PKCα/βII (pThr638/641), phospho-PKC (pan) ...
Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR
Supplier
Han Zhaozhong, In PLoS ONE, 2001
... PKR M02 monoclonal antibody clone 1D11 was from Abnova (Taipei City, Taiwan) ...
NF-κB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-κB inducing kinase and IκB kinase
Supplier
Tisdale M J et al., In British Journal of Cancer, 1999
... (Ser 51) and to phospho-PKR (Thr 446) were purchased from Insight Biotechnology Ltd (London, UK) ...
Papers on PKR
Subtilase cytotoxin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli induces stress granule formation.
New
Noda et al., Kumamoto, Japan. In Cell Microbiol, Feb 2016
Here, we show that SubAB-induced SG formation is regulated by activation of double-stranded RNA-activated protein kinase (PKR)-like endoplasmic reticulum kinase (PERK).
Gene expression analysis during recovery process indicates the mechanism for innate immune injury and repair from Coxsackievirus B3-induced myocarditis.
New
Han et al., Changsha, China. In Virus Res, Feb 2016
The expression of TLRs, RLRs, PKR and cytokines were strongly induced and reached the peak at 4 dpi in early myocarditis stage, followed by a gradual reduction in recovery stage, during which the levels were even lower than normal at 12 dpi.
Role of the IFN I system against the VHSV infection in juvenile Senegalese sole (Solea senegalensis).
New
Garcia-Rosado et al., Málaga, Spain. In Vet Res, Dec 2015
In this study, the stimulation of the Senegalese sole IFN I by VHSV infections has been evaluated by the relative quantification of the transcription of several ISG (Mx, Isg15 and Pkr) after inoculation with marine (pathogenic) and freshwater (non-pathogenic) VHSV isolates.
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.
New
Van Vlierberghe et al., Gent, Belgium. In Bmc Cancer, Dec 2015
RESULTS: Both the genetic and pharmacological inhibitions of PlGF reduced the chaperone levels and the activation of the PKR-like endoplasmic reticulum kinase (PERK) pathway of the UPR in diethylnitrosamine-induced HCC.
Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death.
Review
New
Lin et al., San Diego, United States. In Am J Pathol, Jul 2015
In mammalian cells, three ER transmembrane proteins, inositol-requiring enzyme-1 (IRE1; official name ERN1), PKR-like ER kinase (PERK; official name EIF2AK3), and activating transcription factor-6, control the UPR.
Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response.
Review
New
Pierre et al., Marseille, France. In Febs Lett, Jul 2015
Viral triggering of the innate immune response in infected cells aims at delaying viral replication and prevents tissue spreading.
Tumor progression and the different faces of the PERK kinase.
Review
New
Diehl et al., Charleston, United States. In Oncogene, Jul 2015
UNASSIGNED: The serine/threonine endoplasmic reticulum (ER) kinase, protein kinase R (PKR)-like ER kinase (PERK), is a pro-adaptive protein kinase whose activity is regulated indirectly by protein misfolding within the ER.
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression.
Review
New
Lee, Galveston, United States. In Genomics Inform, Jun 2015
nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR).
Pro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's Disease.
Review
Hugon et al., Paris, France. In Front Neurol, 2014
Here, we present recent evidences from AD experimental models and human studies that three pro-apoptotic kinases (double-stranded RNA kinase (PKR), glycogen synthase kinase-3β, and C-Jun terminal kinase (JNK) could be implicated in AD physiopathology.
PKR and HMGB1 expression and function in rheumatoid arthritis.
Rong et al., Shouguang, China. In Genet Mol Res, 2014
We aimed to examine the roles of double-stranded RNA-activated protein kinase (PKR) and high-mobility group box chromosomal protein 1 (HMGB1) in a rat model of RA.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
Impact
De Felice et al., Rio de Janeiro, Brazil. In Cell Metab, 2014
dsRNA-dependent protein kinase (PKR) underlies peripheral insulin resistance in metabolic disorders.
Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.
Impact
Hetz et al., Santiago, Chile. In Cell Metab, 2014
Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.
Novel role of PKR in inflammasome activation and HMGB1 release.
Impact
GeneRIF
Tracey et al., New York City, United States. In Nature, 2012
results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation
Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses.
Impact
Malik et al., Seattle, United States. In Cell, 2012
To determine mechanisms of adaptation, we subjected the model poxvirus vaccinia to serial propagation in human cells, where its antihost factor K3L is maladapted against the antiviral protein kinase R (PKR).
Increased interaction between PACT molecules in response to stress signals is required for PKR activation.
GeneRIF
Patel et al., Columbia, United States. In J Cell Biochem, 2012
Data demonstrate that PACT-PACT interaction is essential for efficient PKR activation.
Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.
GeneRIF
Samuel et al., Santa Barbara, United States. In Virology, 2012
This study used complementation of human cell lines stably deficient in PKR to probe the basis of PCR-mediated activation of MAPK and interferon beta induction by measles virus.
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
GeneRIF
Chen et al., Cambridge, United States. In Blood, 2012
Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.
GeneRIF
Hugon et al., Paris, France. In Biochim Biophys Acta, 2012
findings provide a new translational regulation of BACE1, under the control of double-stranded RNA dependant protein kinase in oxidative stress, where eIF2-alpha phosphorylation regulates
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense.
Impact
Sadler et al., Australia. In Immunity, 2012
Here we showed that the antiviral protein kinase R (PKR) inhibited the key actin-modifying protein gelsolin to regulate actin dynamics and control cytoskeletal cellular functions under homeostatic conditions.
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