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Plakophilin 3

PKP3, plakophilin 3
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Armadillo, SIMPLE, E-cadherin, HAD, cytokeratin
Papers on PKP3
Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis.
Monga et al., Xi'an, China. In Am J Pathol, Dec 2015
Enhanced association of β-catenin to desmoglein-2 and plakophilin-3 was observed in KO.
Involvement of impaired desmosome-related proteins in hypertrophic scar intraepidermal blister formation.
Wu et al., Chongqing, China. In Burns, Nov 2015
Among the downregulated ones, plakophilin1 (PKP1), plakophilin3 (PKP3) and desmoplakin (DSP) were the desmosome-related proteins which were validated by immunohistochemistry and western blotting assay.
Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice.
Vandenbroucke et al., Gent, Belgium. In Eur J Immunol, Oct 2015
Plakophilin-3 (PKP3) is a member of the armadillo protein family, which is important in cell-cell contacts and signaling during development and tumorigenesis.
c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress.
Schmidt et al., Marburg an der Lahn, Germany. In Cell Tissue Res, Mar 2015
Plakophilins (PKP1 to PKP3) are essential for the structure and function of desmosomal junctions as demonstrated by the severe skin defects observed as a result of loss-of-function mutations in mice and men.
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.
Hofmann et al., Mannheim, Germany. In Mol Cell Biol, 2015
Both PKP1 and PKP3 knockdown cell lines showed reduced protein and mRNA levels for desmoplakin and PKP2.
MMP7 is required to mediate cell invasion and tumor formation upon Plakophilin3 loss.
Dalal et al., Mumbai, India. In Plos One, 2014
Plakophilin3 (PKP3) loss results in increased transformation in multiple cell lines in vitro and increased tumor formation in vivo.
Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation.
Green et al., Chicago, United States. In Mol Biol Cell, 2014
Here we show that the Armadillo protein plakophilin 3 (Pkp3) mediates both desmosome assembly and E-cadherin maturation through Rap1 GTPase, thus functioning in a manner distinct from the closely related plakophilin 2 (Pkp2).
Fetal lung and placental methylation is associated with in utero nicotine exposure.
DeMeo et al., Boston, United States. In Epigenetics, 2014
The most significant CpG sites in the fetal lung analysis mapped to the PKP3 (P = 2.94 × 10(-03)), ANKRD33B (P = 3.12 × 10(-03)), CNTD2 (P = 4.9 × 10(-03)) and DPP10 (P = 5.43 × 10(-03)) genes.
Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3.
Prime et al., Melbourne, Australia. In Autoimmunity, 2014
The cell adhesion molecule plakophilin 3 (Pkp3) plays an essential role in the maintenance of skin integrity and is targeted in certain autoimmune conditions.
An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b.
Schmidt et al., Marburg an der Lahn, Germany. In Cell Tissue Res, 2014
The plakophilin family (PKP1 to PKP3) is an essential component of the desmosomal adhesion complex with differentiation-dependent and partially overlapping expression and possible participation of the corresponding genes in malignant transformation.
Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype.
Pommier et al., Bethesda, United States. In Plos One, 2013
The most highly correlated genes were implicated in the following epithelial functions: interactions at tight junctions (CLDN7, CLDN4, CLDN3, MARVELD3, MARVELD2, TJP3, CGN, CRB3, LLGL2, EPCAM, LNX1); interactions at adherens junctions (CDH1, ADAP1, CAMSAP3); interactions at desmosomes (PPL, PKP3, JUP); transcription regulation of cell-cell junction complexes (GRHL1 and 2); epithelial RNA splicing regulators (ESRP1 and 2); epithelial vesicle traffic (RAB25, EPN3, GRHL2, EHF, ADAP1, MYO5B); epithelial Ca(+2) signaling (ATP2C2, S100A14, BSPRY); terminal differentiation of epithelial cells (OVOL1 and 2, ST14, PRSS8, SPINT1 and 2); maintenance of apico-basal polarity (RAB25, LLGL2, EPN3).
Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity.
McCrea et al., Houston, United States. In Plos One, 2013
Consistent with earlier reports suggesting possible nuclear roles in development, we previously demonstrated prominent nuclear localization of Pkp3 in Xenopus naïve ectoderm ("animal cap") cells and recently resolved a similar localization in mouse embryonic stem cells.
Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.
Hofmann et al., Heidelberg, Germany. In Virchows Arch, 2013
The RNA-binding proteins (RBPs) GAP-SH3-binding protein (G3BP), fragile-X-related protein 1 (FXR1), poly(A)-binding protein, cytoplasmic 1 (PABPC1), and up-frameshift factor 1 (UPF1) are associated with PKP3.
Stratifin (14-3-3 σ) limits plakophilin-3 exchange with the desmosomal plaque.
Wahl et al., Lincoln, United States. In Plos One, 2012
We utilized a proteomics approach to identify plakophilin-3 associated proteins and identified the 14-3-3 family member stratifin.
Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis.
Hawn et al., Seattle, United States. In J Infect Dis, 2012
These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts.
Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer.
Kanayama et al., Tokushima, Japan. In Urology, 2012
PKP3 gene down regulation is associated with bladder cancer invasion.
Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.
Dalal et al., Mumbai, India. In Plos One, 2011
Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.
E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly.
Dalal et al., Mumbai, India. In Cell Mol Life Sci, 2011
plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation
Expression of plakophilins (PKP1, PKP2, and PKP3) in gastric cancers.
Yucel et al., Samsun, Turkey. In Diagn Pathol, 2010
loss of PKP3 expression during gastric adenocarcinoma progression may indicate an invasive phenotype.
Molecular diversity of plaques of epithelial-adhering junctions.
Franke et al., Heidelberg, Germany. In Ann N Y Acad Sci, 1999
Similarly, plakophilin 3 is present in the desmosomal plaques of intestinal and colonic cells but appears to be absent from the hepatocytic desmosomes.
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