gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Protein kinase N3

PKNbeta, PKN3, protein kinase N3
Top mentioned proteins: ACID, PRK2, Rhodopsin, CAN, HAD
Papers on PKNbeta
PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
New
Sugiura et al., Kōbe, Japan. In Sci Rep, Dec 2015
Furthermore, the enrichment of PKN3 mRNA in some cancer cell lines as well as its requirement in malignant prostate cell growth suggested its involvement in oncogenesis.
Therapeutic effect for liver-metastasized tumor by sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA.
New
Yonemochi et al., Tokyo, Japan. In J Drug Target, Sep 2015
Finally, sequential injections of CS plus cationic lipoplex of protein kinase N3 siRNA could suppress tumor growth in the mice bearing liver metastasis.
Therapeutic effect for liver-metastasized tumor by sequential intravenous injection of anionic polymer and cationic lipoplex of siRNA.
New
Yonemochi et al., Tokyo, Japan. In J Drug Target, Sep 2015
Finally, sequential injections of CS plus cationic lipoplex of protein kinase N3 siRNA could suppress tumor growth in the mice bearing liver metastasis.
First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
Impact
Drevs et al., Tübingen, Germany. In J Clin Oncol, 2015
PURPOSE: Atu027 is a novel liposomal RNA interference therapeutic that includes a short-interfering RNA (siRNA), which silences expression of protein kinase N3 in the vascular endothelium.
Protein Kinase C-Related Kinase (PKN/PRK). Potential Key-Role for PKN1 in Protection of Hypoxic Neurons.
Baier-Bitterlich et al., Innsbruck, Austria. In Curr Neuropharmacol, 2014
Serine/threonine protein kinase C-related kinase (PKN/PRK) is a family of three isoenzymes (PKN1, PKN2, PKN3), which are widely distributed in eukaryotic organisms and share the same overall domain structure.
Enzyme Kinetics and Distinct Modulation of the Protein Kinase N Family of Kinases by Lipid Activators and Small Molecule Inhibitors.
Timofeevski et al., In Biosci Rep, 2014
Inhibition of tumor PKN activity has been explored as an oncology therapeutic approach, with a PKN3-targeted RNAi-derived therapeutic agent in Phase I clinical trials.
Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.
Tripp et al., Athens, United States. In Plos One, 2012
From the screen, 17 HPKs (NPR2, MAP3K1, DYRK3, EPHA6, TPK1, PDK2, EXOSC10, NEK8, PLK4, SGK3, NEK3, PANK4, ITPKB, CDC2L5 (CDK13), CALM2, PKN3, and HK2) were validated as essential for A/WSN/33 influenza virus replication, and 6 HPKs (CDK13, HK2, NEK8, PANK4, PLK4 and SGK3) were identified as vital for both A/WSN/33 and A/New Caledonia/20/99 influenza virus replication.
Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation.
Santel et al., Berlin, Germany. In Eur J Cell Biol, 2012
Here we report that protein kinase N3 (PKN3) appears to play a pivotal role in maintaining endothelial cell morphology, cell-cell junctions and motility.
The interaction of PKN3 with RhoC promotes malignant growth.
GeneRIF
Klippel et al., Pearl River, United States. In Mol Oncol, 2012
Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.
Site recognition and substrate screens for PKN family proteins.
Parker et al., London, United Kingdom. In Biochem J, 2011
In the present study, we have re-evaluated and compared the specificity of PKN1 and PKN3 and assessed the predictive value in substrates.
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.
GeneRIF
Parker et al., London, United Kingdom. In Plos One, 2010
PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It
Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models.
Kaufmann et al., Berlin, Germany. In Clin Cancer Res, 2010
In vitro studies in human umbilical vein endothelial cells were carried out to provide an insight into molecular changes on depletion of PKN3, in support of efficacy results.
Recurrent deletion of 9q34 in adult normal karyotype precursor B-cell acute lymphoblastic leukemia.
Wetzler et al., Buffalo, United States. In Cancer Genet Cytogenet, 2010
The results demonstrate cryptic deletions of 9q34 involving SET, PKN3, NUP188, ABL1, and NUP214 in three of the samples.
High-throughput functional genomic methods to analyze the effects of dietary lipids.
Review
Kitajka et al., Szeged, Hungary. In Curr Pharm Biotechnol, 2006
Several genes were identified that exhibited altered expression in response to fish-oil treatment of human lung cancer cells, including protein kinase C, natriuretic peptide receptor-A, PKNbeta, interleukin-1 receptor associated kinase-1 (IRAK-1) and diacylglycerol kinase genes by using high-throughput quantitative real-time PCR.
PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
GeneRIF
Klippel et al., Berlin, Germany. In Embo J, 2004
PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC.
Review
Mukai, Kōbe, Japan. In J Biochem, 2003
There are at least three different isoforms of PKN (PKNalpha/PAK-1/PRK-1, PKNbeta, and PRK2/PAK-2/PKNgamma) in mammals, each of which shows different enzymological properties, tissue distribution, and varied functions.
share on facebooktweetadd +1mail to friends