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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Adenosine deaminase, RNA-specific

PKI, Dishevelled, ADAR1, Dvl, L-PK
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: V1a, CAN, Frizzled, Dvl2, ACID
Papers using PKI antibodies
Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells
Yang Hsin-Ling et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... -catenin, anti-rabbit survivin, anti-rabbit p53, anti-rabbit cytochrome c, anti-rabbit caspase-3, and anti-goat Dvl antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis.
de Windt Leon J., In PLoS ONE, 2007
... eIF2α, JNK1, phospho-c-Jun (p-Ser73), GRP78, CHOP (GADD153), KDEL receptor, XBP1, phosphorylated CaMKIIδ, CaMKIIδ, β-actin and PKI (6–22) were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction
Li Lin et al., In The Journal of Cell Biology, 2003
... The antibodies used were: β-catenin (14/β-catenin; BD Biosciences), TCF-4 (6H5-3; Millipore), Dvl-2 (10B5; Santa Cruz Biotechnology, Inc.), and c-Jun (H-79; ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti-Dvl antibody was obtained from Santa Cruz Biotechnology, Inc ...
Papers on PKI
ADAR1, inosine and the immune sensing system: distinguishing self from non-self.
Walkley et al., Australia. In Wiley Interdiscip Rev Rna, Jan 2016
This process is catalyzed by two of the three mammalian ADAR proteins (ADAR1 and ADAR2) both of which have essential functions for normal organismal homeostasis.
Calcitonin gene-related peptide inhibits autophagic-lysosomal proteolysis through cAMP/PKA signaling in rat skeletal muscles.
Navegantes et al., São Paulo, Brazil. In Int J Biochem Cell Biol, Jan 2016
In denervated muscles and starved C2C12 cells, Rp-8-Br-cAMPs or PKI, two PKA inhibitors, completely abolished the inhibitory effect of CGRP on Foxo1, 3 and 4 and LC3 lipidation.
Differential A-to-I RNA editing of the serotonin-2C receptor G-protein-coupled, HTR2C, in porcine brain tissues.
Bendixen et al., Århus, Denmark. In Biochimie, Jan 2016
The HTR2C mRNA is subject to A-to-I RNA editing mediated by adenosine deaminases acting on RNA 1 and 2 (ADAR1 and ADAR2).
A-to-I editing of coding and non-coding RNAs by ADARs.
Nishikura, Philadelphia, United States. In Nat Rev Mol Cell Biol, Jan 2016
Conversely, recent studies indicate that ADAR1 forms a complex with Dicer to promote miRNA processing, revealing a new function of ADAR1 in the regulation of RNA interference.
Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus.
Scavone et al., São Paulo, Brazil. In Aging (albany Ny), Jan 2016
Aging also seems to induce a progressive decrease in canonical WNT/β-CATENIN signaling pathway once there is a decrease in DVL-2 levels and in the transcription ofAxin2 gene.
The Epitranscriptome and Innate Immunity.
Keegan et al., Brno, Czech Republic. In Plos Genet, Dec 2015
This review will explore this question by focusing primarily on adenosine to inosine (A-to-I) RNA editing by the adenine deaminase acting on RNA (ADAR) enzymes that have been intensively studied for the past 20 years and have a wide range of effects.
Differential Diagnosis of Two Chinese Families with Dyschromatoses by Targeted Gene Sequencing.
Ma et al., Beijing, China. In Chin Med J (engl), Dec 2015
All mutations detected on ADAR1 and ABCB6 genes were analyzed according to the frequency in control database, the mutation types, and the published evidence to determine the pathogenicity.
Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.
Bienz et al., Cambridge, United Kingdom. In Open Biol, Dec 2015
Its levels are controlled by ubiquitylation, mediated by various ubiquitin ligases, including NEDD4 family members that bind to a conserved PPxY motif in Dishevelled (mammalian Dvl1-3).
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
Stetson et al., Seattle, United States. In Immunity, Dec 2015
Mutations in ADAR, which encodes the ADAR1 RNA-editing enzyme, cause Aicardi-Goutières syndrome (AGS), a severe autoimmune disease associated with an aberrant type I interferon response.
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.
Walkley et al., Australia. In Science, Oct 2015
Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes.
RNA rewriting, recoding, and rewiring in human disease.
Jamieson et al., Los Angeles, United States. In Trends Mol Med, Sep 2015
ADAR (adenosine deAminase acting on RNA) editases catalyze the deamination of adenosine to inosine (A-to-I), a post-transcriptional modification that alters coding and non-coding RNA stability and function.
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Bar-Eli et al., Houston, United States. In Nat Cell Biol, Mar 2015
We present evidence of CREB-mediated low expression of ADAR1 in metastatic melanoma cell lines and tumour specimens.
Upregulated expression of DIXDC1 in intestinal-type gastric carcinoma: co-localization with β-catenin and correlation with poor prognosis.
Sheng et al., Shanghai, China. In Cancer Cell Int, 2014
BACKGROUND: DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway.
The Supraspliceosome - A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus.
Sperling et al., Israel. In Comput Struct Biotechnol J, 2014
Supraspliceosomes harbor additional pre-mRNA processing components, such as the 5'-end and 3'-end processing components, and the RNA editing enzymes ADAR1 and ADAR2.
Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome.
Ramakrishnan et al., Cambridge, United Kingdom. In Cell, 2014
In both states, the pseudoknot PKI of the CrPV-IRES mimics a tRNA/mRNA interaction in the decoding center of the A site of the 40S ribosomal subunit.
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
Wang et al., Birmingham, United Kingdom. In Dev Biol, 2012
A Wnt5a--> Dvl PCP signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
Fukuda et al., Sendai, Japan. In J Biol Chem, 2012
Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP.
Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila.
Rosbash et al., Waltham, United States. In Mol Cell, 2012
Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally.
Planar cell polarity controls directional Notch signaling in the Drosophila leg.
Galindo et al., Valencia, Spain. In Development, 2012
Mutations that compromise a direct interaction between Dishevelled and Notch reduce the efficacy of repression.
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility.
Takahashi et al., Nagoya, Japan. In Nat Commun, 2011
Findings indicate that Daple interacts with Dishevelled to direct the Dishevelled/protein kinase lambda protein complex to activate Rac, which in turn mediates the non-canonical Wnt signalling pathway required for cell migration.
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