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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein kinase, cGMP-dependent, type I

PKG, PGK, desmocollin
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: V1a, CAN, HAD, Phosphodiesterase, iNOS
Papers using PKG antibodies
DNase I-hypersensitive sites enhance α1(I) collagen gene expression in hepatic stellate cells.
Supplier
Fraser Peter, In PLoS ONE, 2002
... EGFP was subcloned into pROSA26-1 along with the selectable marker from pLTNL in which the PGK-Neo resistance gene had been swapped for an SV40-Puro-SV40 polyA derived from pPUR (Clontech).
Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy
Supplier
Stremmel Wolfgang et al., In The Journal of Cell Biology, 1999
... PGK-Cre transgenic mice (provided by Klas ...
Papers on PKG
Evaluation of two novel barcodes for species recognition of opportunistic pathogens in Fusarium.
New
Levesque et al., Utrecht, Netherlands. In Fungal Biol, Feb 2016
We demonstrate the potential of two recently discovered DNA barcode loci, topoisomerase I (TOP1) and phosphoglycerate kinase (PGK), in combination with other routinely used markers such as TEF1, in an analysis of 144 Fusarium strains belonging to 52 species.
Persistent Activation of cGMP-dependent Protein Kinase by a Nitrated Cyclic Nucleotide Via Site-specific Protein S-Guanylation.
New
Akaike et al., In Biochemistry, Feb 2016
Here, we demonstrate that 8-nitro-cGMP potentially S-guanylates thiol groups of cGMP-dependent protein kinase (PKG), the enzyme that serves as one of the major receptor proteins for intracellular cGMP and controls a variety of cellular responses.
Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network.
New
Winslow et al., Baltimore, United States. In J Mol Cell Cardiol, Feb 2016
Finally, we show that PDE2 compensates for inhibition of PDE5 both in terms of cGMP and cAMP dynamics, leading to cGMP elevation and increased PKG activation, while maintaining whole-cell β-adrenergic responses similar to that prior to PDE5 inhibition.
Stimulation of calcium-sensing receptors induces endothelium-dependent vasorelaxations via nitric oxide production and activation of IKCa channels.
New
Albert et al., London, United Kingdom. In Vascul Pharmacol, Feb 2016
NO stimulates PKG leading to BKCa activation in vascular smooth muscle cells, whereas IKCa activity contributes to endothelium-derived hyperpolarisations.
Protein kinase G signaling in cardiac pathophysiology:Impact of proteomics on clinical trials.
Review
New
Van Eyk et al., Maywood, United States. In Proteomics, Jan 2016
UNASSIGNED: The protective role of cyclic guanosine monophosphate/protein kinase G (cGMP/PKG) in the heart makes it an attractive target for therapeutic drug development to treat a variety of cardiac diseases.
Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor.
New
Du et al., Beijing, China. In Biosci Trends, Dec 2015
Using specific cyclic GMP-dependent protein kinase type I (PKG-I), p38 mitogen-activated protein kinases (p38MAPK) and A3 adenosine receptor (A3AR) inhibitors, SERT expression was evaluated by western blot and immunofluorescence analysis.
Carbon monoxide: A new player in the redox regulation of connexin hemichannels.
Review
New
González et al., Santiago, Chile. In Iubmb Life, Jun 2015
CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG.
Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system.
Review
Eaton et al., London, United Kingdom. In Front Pharmacol, 2014
In this review we focus on the role of cGMP-dependent protein kinase (PKG) Ia disulfide dimerisation, an oxidative modification that is induced by oxidants that directly activates the enzyme, discussing how this impacts on the cardiovascular system.
Pathophysiology of erectile dysfunction.
Review
Bivalacqua et al., Baltimore, United States. In Curr Drug Targets, 2014
Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-α).
Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.
Review
Garcia-Osta et al., Recife, Brazil. In Mediators Inflamm, 2014
Phosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases.
cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2.
GeneRIF
Yuasa et al., Tokushima, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that DAPK2 is one of the targets of cGK-I in apoptosis induction.
Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi.
Impact
Bölker et al., Marburg an der Lahn, Germany. In Nature, 2012
Here we show that in numerous fungal species, several core enzymes of glycolysis, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and 3-phosphoglycerate kinase (PGK), reside in both the cytoplasm and peroxisomes.
Induction of apoptosis by type Iβ protein kinase G in the human breast cancer cell lines MCF-7 and MDA-MB-468.
GeneRIF
Salami et al., Tehrān, Iran. In Cell Biochem Funct, 2012
PKGIbeta inhibited cell growth and inducd apoptosis in breast cancer cells.
cGMP-dependent protein kinase Iα transfection inhibits hypoxia-induced migration, phenotype modulation and annexins A1 expression in human pulmonary artery smooth muscle cells.
GeneRIF
Lu et al., Chongqing, China. In Biochem Biophys Res Commun, 2012
cGMP-dependent protein kinase (PKG) Ialpha transfection significantly attenuated the hypoxia-induced down-regulation of the expressions of SM-alpha-actin, MHC and calponin.
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes.
GeneRIF
Green et al., Chicago, United States. In J Cell Biol, 2012
The Dsc2 exhibit microtubule-dependent transport in epithelial cells but use distinct motors to traffic to the plasma membrane.
Desmocollin 2 is a new immunohistochemical marker indicative of squamous differentiation in urothelial carcinoma.
GeneRIF
Yasui et al., Hiroshima, Japan. In Histopathology, 2011
DSC2 is a useful immunohistochemical marker for separation of Urothelial carcinoma with squamous differentiation from pure Urothelial carcinoma
Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.
Impact
Luo et al., Beijing, China. In Science, 2011
These results indicate important behavioral and physiological functions for the GC-C/PKG signaling pathway within the brain and suggest new therapeutic targets for neuropsychiatric disorders related to the malfunctions of midbrain dopamine neurons.
Semaphorin 3A induces CaV2.3 channel-dependent conversion of axons to dendrites.
Impact
Hong et al., New York City, United States. In Nat Cell Biol, 2011
Furthermore, Sema3A-triggered cGMP production and PKG activity induced, respectively, the expression of functional Ca(V)2.3 and the dendrite identity.
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
Review
Impact
Sibley et al., Nashville, United States. In Pharmacol Rev, 2010
cGMP binding activates PKG, which phosphorylates serines and threonines on many cellular proteins, frequently resulting in changes in activity or function, subcellular localization, or regulatory features.
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.
Impact
Holland et al., New York City, United States. In Cell Stem Cell, 2010
The NO/cGMP/PKG pathway's promotion of stem cell-like character in the tumor PVN may identify therapeutic targets for this subset of gliomas.
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