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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Polycystic kidney disease 1-like 2

PKD1L2, Polycystin-1L2, PC1L2, KIAA1879
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PC1, PC2, Pkd1l1, ACID, Syngap
Papers on PKD1L2
Direct recording and molecular identification of the calcium channel of primary cilia.
Clapham et al., Boston, United States. In Nature, 2014
The polycystin proteins (PC and PKD), identified in linkage studies of polycystic kidney disease, are candidate channels divided into two structural classes: 11-transmembrane proteins (PKD1, PKD1L1 and PKD1L2) remarkable for a large extracellular amino terminus of putative cell adhesion domains and a G-protein-coupled receptor proteolytic site, and the 6-transmembrane channel proteins (PKD2, PKD2L1 and PKD2L2; TRPPs).
The TRPP subfamily and polycystin-1 proteins.
Hofherr et al., Freiburg, Germany. In Handb Exp Pharmacol, 2013
The identification of additional TRPP (TRPP3 and TRPP5) and polycystin-1-like proteins (PKD1L1, PKD1L2, PKD1L3, and PKDREJ) has added yet another layer of complexity to these fascinating cellular signalling units.
Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse.
Blanco et al., United Kingdom. In Hum Mol Genet, 2009
Ectopic expression of PKD1L2 in transgenic mice caused severe muscle atrophy.
Polycystin-1L2 is a novel G-protein-binding protein.
Zhou et al., Boston, United States. In Genomics, 2004
PKD1L2 is expressed in the developing and adult heart and kidney.
Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes.
Somlo et al., New Haven, United States. In Genomics, 2003
genes are mapped to chromosomes and gene structures are characterized; protein structure is predicted and contains strong ion channel signature motifs that suggest their possible function as components of cation channel pores
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.
Ohara et al., Kisarazu, Japan. In Dna Res, 2001
As an extension of a sequencing project of human cDNA clones which encode large proteins of unidentified genes, we herein present the entire sequences of 60 cDNA clones for the genes named KIAA1879-KIAA1938.
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