Mechanisms of insulin resistance in the amygdala: influences on food intake.
Campinas, Brazil. In Behav Brain Res, May 2015
High fat diet and saturated fatty acids induce inflammation, ER (endoplasmic reticulum) stress and the activation of serine kinases such as PKCθ (protein kinase C theta), JNK (c-Jun N-terminal kinase) and IKKβ (inhibitor of nuclear factor kappa-B kinase beta) in the amygdala, which have an important role in insulin resistance in this brain region.
Pathophysiology of rheumatoid arthritis.
Newcastle upon Tyne, United Kingdom. In Curr Opin Rheumatol, 2011
Important work on signalling within regulatory T cells has identified sequestration of protein kinase C theta away from the immune synapse as critical for suppressive activity; TNFα exposure interferes with protein kinase C theta compartmentalisation, explaining its inhibition of regulatory T cell function.
T helper cell differentiation: understanding the needs of hierarchy.
Vienna, Austria. In Immunity, 2010
In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.