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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Protein kinase C, theta

PKCtheta, protein kinase C theta
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: THETA, NF-kappaB, CAN, Protein Kinase C-alpha, Interleukin-2
Papers on PKCtheta
T-3: RECIPROCAL ACTIVATION OF PLATELETS AND CD4+TREGS FOLLOWING TRAUMA.
New
Hanschen et al., München, Germany. In Shock, Oct 2015
Treg activation was measured using phospho- and conventional flow cytometry (ZAP-70, PKC-theta).
Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome.
New
Finley, Houston, United States. In Med Hypotheses, Sep 2015
It is our hypothesis that activation of AMPK, a master regulator of cellular metabolism which has been shown to activate PKC-theta (θ) and is essential for T cell activation, may modulate the splicing activities of SRp55 as well as enhance a p32-mediated inhibition of ASF/SF2-induced alternative splicing, potentially correcting aberrant alternative splicing in the LMNA gene and reactivating latent viral HIV-1 reservoirs.
Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability.
New
Shirai et al., Tsukuba, Japan. In Bioorg Med Chem, Aug 2015
Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis.
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
New
Cirone et al., Roma, Italy. In Biochim Biophys Acta, Jul 2015
PKC activation by combining TPA with sodium butyrate (T/B) represents the most effective and widely used strategy to induce the Epstein-Barr virus (EBV) lytic cycle.
Mechanisms of insulin resistance in the amygdala: influences on food intake.
Review
New
Prada et al., Campinas, Brazil. In Behav Brain Res, May 2015
High fat diet and saturated fatty acids induce inflammation, ER (endoplasmic reticulum) stress and the activation of serine kinases such as PKCθ (protein kinase C theta), JNK (c-Jun N-terminal kinase) and IKKβ (inhibitor of nuclear factor kappa-B kinase beta) in the amygdala, which have an important role in insulin resistance in this brain region.
Nesfatin-1 Suppresses Cardiac L-type Ca²⁺ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway.
Zhang et al., In Cell Physiol Biochem, 2014
Application of NF-1 increased membrane abundance of PKC theta isoform (PKCθ), and PKCθ inhibition abolished the decrease in ICa,L induced by NF-1.
Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours.
Review
Oda et al., Fukuoka, Japan. In Histopathology, 2013
All were negative for KIT, CD34, protein kinase C theta and DOG1.
Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation.
GeneRIF
Cho et al., Chicago, United States. In J Biol Chem, 2012
establish the C2 domain of PKCtheta; as a Tyr(P)-binding domain and suggest that the domain may play a major role in PKCtheta; activation via its Tyr(P) binding.
DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex.
GeneRIF
Xia et al., Changzhou, China. In Exp Neurol, 2012
delta opioid receptor activation inhibits anoxia-induced Na (sodium)+ influx through Na+ channels via PKC, especially via PKCbetaII and PKCtheta; isozyme-dependent mechanisms in the cortex.
Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.
GeneRIF
Sun et al., Duarte, United States. In J Immunol, 2012
PKC-theta; upregulates Stat3 resulting in Th17 differentiation
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
GeneRIF
Sun et al., Duarte, United States. In J Immunol, 2012
PKC-theta; controls T cell-mediated immune responses by shifting the balance between the differentiation of effector T cells and inhibitory T regulatory (Treg) cells.
Pathophysiology of rheumatoid arthritis.
Review
Isaacs et al., Newcastle upon Tyne, United Kingdom. In Curr Opin Rheumatol, 2011
Important work on signalling within regulatory T cells has identified sequestration of protein kinase C theta away from the immune synapse as critical for suppressive activity; TNFα exposure interferes with protein kinase C theta compartmentalisation, explaining its inhibition of regulatory T cell function.
PKC-θ is a drug target for prevention of T cell-mediated autoimmunity and allograft rejection.
Review
Sun et al., Los Angeles, United States. In Endocr Metab Immune Disord Drug Targets, 2010
Protein kinase C theta (PKC-θ) is a key kinase in mediating T cell receptor (TCR) signals.
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
Impact
Boothby et al., Nashville, United States. In Immunity, 2010
Complementation with active Akt restored only T-bet transcription factor expression and Th1 cell differentiation, whereas activated PKC-theta reverted only GATA3 transcription factor and the Th2 cell defect of mTORC2 mutant cells.
T helper cell differentiation: understanding the needs of hierarchy.
Impact
Säemann et al., Vienna, Austria. In Immunity, 2010
In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.
Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.
Impact
Dustin et al., New York City, United States. In Immunity, 2010
Using siRNA in primary T cells, we show that Ub recognition by TSG101 is required for cSMAC formation, TCR MC signal termination, TCR downregulation, and segregation of TCR-MHC-peptide from PKC-theta-enriched signaling complexes.
Protein kinase C-theta mediates negative feedback on regulatory T cell function.
Impact
GeneRIF
Dustin et al., New York City, United States. In Science, 2010
formation of immunological synapse(IS) induces altered signal pathways in Treg, characterized by reduced recruitment of Src kinases, PKC-theta & Carma-1 to the IS; in Treg, PKC-theta acts as a proinflammatory mediator & this effect is enhanced by TNFalpha
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Review
Poole et al., Bristol, United Kingdom. In J Thromb Haemost, 2010
Similarly, PKCbeta, PKCdelta and PKCtheta have non-redundant roles in platelet spreading, as absence of either PKCbeta or PKCtheta reduces spreading, whereas PKCdelta negatively regulates filopodial formation.
Nfix regulates fetal-specific transcription in developing skeletal muscle.
Impact
Cossu et al., Milano, Italy. In Cell, 2010
In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A.
Activity of novel protein kinase C and distribution of protein kinase C theta in subcellular fractions of normal and Duchenne muscular dystrophic muscle.
GeneRIF
Anandaraj et al., Hyderābād, India. In Indian J Biochem Biophys, 2002
alterations in nPKC location and increased expression of PKC theta observed is a result of modification of PKC-mediated signal transduction and cell function
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