Repression of cancer cell senescence by PKCι.
Ottawa, Canada. In Oncogene, 2012
It was concluded that protein kinase C iota is overexpressed in a subset of cancers where the enzyme functions to suppress premature senescence. This function appears to be restricted to cancer cells.
Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer.
Jacksonville, United States. In Biochem Soc Trans, 2007
To date, however, only one PKC isoenzyme, the aPKC [atypical PKCiota (protein kinase Ciota)], has been identified as a human oncogene [Regala, Weems, Jamieson, Khoor, Edell, Lohse and Fields (2005) Cancer Res.
The function of MITF and associated proteins in mast cells.
Jerusalem, Israel. In Mol Immunol, 2002
A search for MITF-associated proteins, using a mast cell library that was screened with a construct that encodes the basic helix-loop-helix leucine zipper (bHLH-Zip) domain of MITF, resulted in the isolation of the protein kinase C interacting (PKCI) protein 1 and protein inhibitor of activated STAT3 (PIAS3).