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proteins. Page last changed on 14 Mar 2013.
Protein kinase C, beta
PKCbeta, protein kinase C beta
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
PKCbeta
[Association between mannose-binding lectin 2 gene and protein kinase C-beta 1 gene polymorphisms and type 2 diabetic macrovascular complications in northern Chinese Han population].
New
Jinan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Dec 2012
OBJECTIVE: To assess the association between single nucleotide polymorphisms (SNPs) of mannose-binding lectin 2 gene (MBL2) (rs1800450, rs1800451 and rs11003125) and protein kinase C-beta 1 gene (PRKC beta 1) (rs3700106, rs2575390) with diabetic macroangiopathy in northern Chinese Han population.
Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.
New
Sunnyvale, United States. In Inflamm Res, Dec 2012
The inhibitor also blocked diet-induced elevations of uNGAL and albumin-creatinine ratio (UACR) as well as kidney tissue phosphorylation of PKC-beta-2-T641 and p66shc-S36, and reduced dark ring-like staining of nuclei by anti-phos-p66shc-S36 antibody in frozen sections of diseased kidneys from hypertensive Dahl rats fed an 8 % NaCl diet for 4 weeks.
PROX1 overexpression inhibits protein kinase C beta II transcription through promoter DNA methylation.
New
Nagoya, Japan. In Genes Chromosomes Cancer, Nov 2012
Treatment with a demethylating agent, 5-aza-2'-deoxycytidine, restored PRKCB2 mRNA expression in PROX1-expressing cells, suggesting that the 5'-promoter of PRKCB is methylated in these cells.
A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).
New
Glasgow, United Kingdom. In Neuro Oncol, Mar 2012
We report a phase 1 study to examine the safety and recommended dose of the oral protein kinase C-beta inhibitor (anti-angiogenic) enzastaurin in combination with single-agent temozolomide.
Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats.
Liverpool, United Kingdom. In Int J Gen Med, 2011
Expression of protein kinase C beta, phosphatidylinositol 3, Shc, insulin receptor substrate 1, ERK1/2, and endothelial nitric oxide synthase was significantly increased by dietary obesity, while that of insulin receptor beta, insulin receptor substrate 1, and protein kinase B (Akt) were not affected by obesity.
Protein kinase C β inhibition ameliorates experimental mesangial proliferative glomerulonephritis.
GeneRIF
Melbourne, Australia. In Nephrology (carlton), 2011
Report amelioration of the pathological findings of experimental mesangial proliferative glomerulonephritis by PKC-beta inhibition.
Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.
GeneRIF
Zürich, Switzerland. In Arterioscler Thromb Vasc Biol, 2011
oxidized LDL also increased phosphorylation of protein kinase C beta(2) (PKCbeta(2)) at both Thr641 and Ser660, as well as c-Jun N-terminal kinase
Disruption of the murine protein kinase Cbeta gene promotes gallstone formation and alters biliary lipid and hepatic cholesterol metabolism.
GeneRIF
Columbus, United States. In J Biol Chem, 2011
unrecognized role of PKCbeta in fine tuning diet-induced cholesterol and bile acid homeostasis, thus identifying PKCbeta as a major physiological regulator of both triglyceride and cholesterol homeostasis.
Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held.
GeneRIF
Boston, United States. In Neuron, 2011
This experiments establish that PKCalpha and PKCbeta are crucial for posttetanic potentiation and suggest that long-lasting presynaptic calcium increases produced by tetanic stimulation may activate these isoforms to produce posttetanic potentiation.
Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.
GeneRIF
Galveston, United States. In J Immunol, 2011
Results establish a causative role for PKCbetaII and L-plastin in linking GM-CSF-induced eosinophil priming for chemotaxis.
Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats.
Review
Pusan, South Korea. In Prog Biophys Mol Biol, 2010
The expression level of 5-HT(2A), but not 5-HT(2B), receptor and the expression levels of total PKC, PKCbeta, and PKCepsilon, but not PKCalpha, were higher in the mesenteric arteries of OLETF rats compared with LETO rats.
Genetic variants of the protein kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes.
Impact
GeneRIF
Hong Kong, Hong Kong. In Jama, 2010
Genetic variants in the PRKCB1 gene were independently associated with development of ESRD in Chinese patients with type 2 diabetes.
Activation of protein kinase C isoforms and its impact on diabetic complications.
Review
Boston, United States. In Circ Res, 2010
Clinical trials using a PKC-beta isoform inhibitor have been conducted, with some positive results for diabetic nonproliferative retinopathy, nephropathy, and endothelial dysfunction.
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
Impact
GeneRIF
Freiburg, Germany. In Nature, 2010
phosphorylation of histone H3 at threonine 6 (H3T6) by protein kinase C beta I (PKCbeta(I), also known as PRKCbeta) is the key event that prevents LSD1 from demethylating H3K4 during AR-dependent gene activation
Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies.
Review
Amsterdam, Netherlands. In Neuro Oncol, 2010
The main findings were that (i) efficacy of small-molecule kinase inhibitors in clinical studies with glioblastoma patients does not yet warrant a change in standard clinical practice and (ii) 6 main kinase targets for inhibitors have been evaluated in these studies: EGFR, mTOR, KDR, FLT1, PKCbeta, and PDGFR.
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Review
Bristol, United Kingdom. In J Thromb Haemost, 2010
Similarly, PKCbeta, PKCdelta and PKCtheta have non-redundant roles in platelet spreading, as absence of either PKCbeta or PKCtheta reduces spreading, whereas PKCdelta negatively regulates filopodial formation.
Signal transduction inhibitor therapy for lymphoma.
Review
Rochester, United States. In Hematology Am Soc Hematol Educ Program, 2009
This review focuses on three signaling pathways: the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, the B-cell receptor/spleen tyrosine kinase (BCR/Syk) pathway, and the protein kinase C-beta (PKC-β) pathway, known to be important to lymphoma cells.
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
Impact
Indianapolis, United States. In J Clin Oncol, 2007
OBJECTIVE: Protein kinase C beta (PKCbeta) was identified by gene-expression profiling, preclinical evaluation, and independent immunohistochemical analysis as a rational therapeutic target in diffuse large B-cell lymphoma (DLBCL).
Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.
Impact
GeneRIF
Ferrara, Italy. In Science, 2007
results show Pkcb, activated by oxidative conditions, induces phosphorylation of p66Shc & triggers its accumulation in mitochondria after it is recognized by Pin1; data identify a signaling route that activates an apoptotic inducer shortening life span
Control of local actin assembly by membrane fusion-dependent compartment mixing.
Impact
Madison, United States. In Nat Cell Biol, 2007
DAG, in turn, directs long-term recruitment of protein kinase Cbeta (PKCbeta) to exocytosing cortical granules, where it is required for activation of Cdc42 localized on the cortical granules.
