Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.
Sunnyvale, United States. In Inflamm Res, Dec 2012
The inhibitor also blocked diet-induced elevations of uNGAL and albumin-creatinine ratio (UACR) as well as kidney tissue phosphorylation of PKC-beta-2-T641 and p66shc-S36, and reduced dark ring-like staining of nuclei by anti-phos-p66shc-S36 antibody in frozen sections of diseased kidneys from hypertensive Dahl rats fed an 8 % NaCl diet for 4 weeks.
Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats.
Liverpool, United Kingdom. In Int J Gen Med, 2011
Expression of protein kinase C beta, phosphatidylinositol 3, Shc, insulin receptor substrate 1, ERK1/2, and endothelial nitric oxide synthase was significantly increased by dietary obesity, while that of insulin receptor beta, insulin receptor substrate 1, and protein kinase B (Akt) were not affected by obesity.
Signal transduction inhibitor therapy for lymphoma.
Rochester, United States. In Hematology Am Soc Hematol Educ Program, 2009
This review focuses on three signaling pathways: the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, the B-cell receptor/spleen tyrosine kinase (BCR/Syk) pathway, and the protein kinase C-beta (PKC-β) pathway, known to be important to lymphoma cells.