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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Intestine-specific homeobox

PIXI, ISX
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CAN, ACID, V1a, CIs, CD36
Papers on PIXI
The binding mechanism of a novel nicotinamide isostere inhibiting with TNKSs: a molecular dynamic simulation and binding free energy calculation.
New
Han et al., Hefei, China. In J Biomol Struct Dyn, Jan 2016
The specific binding modes are investigated between the TNKS1 protein and nicotinamide isostere (ISX) which functions as an inhibitor of TNKS1.
Genome-wide association study with the risk of schizophrenia in a Korean population.
New
Woo et al., Seoul, South Korea. In Am J Med Genet B Neuropsychiatr Genet, Dec 2015
In the case-control analysis, the rs9607195 A>G on intergenic area 250 kb away from the ISX gene and the rs12738007 A>G on the intron of the MECR gene were the most strongly associated SNPs with the risk of schizophrenia (P = 6.2 × 10(-8) , OR = 0.50 and P = 3.7 × 10(-7) , OR = 2.39, respectively).
A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption.
New
Von Lintig et al., Cleveland, United States. In Hum Mol Genet, Jul 2015
In this process, conversion of β-carotene to vitamin A by BCO1 induces via retinoid signaling the expression of the intestinal homeobox transcription factor ISX. Subsequently, ISX binds to conserved DNA-binding motifs upstream of the BCO1 and SCARB1 genes.
Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements.
Bachtrog et al., Berkeley, United States. In Elife, 2014
Transposable elements (TEs) allow rewiring of regulatory networks, and the recent amplification of the ISX element dispersed 77 functional but suboptimal binding sites for the dosage compensation complex to a newly formed X chromosome in Drosophila.
1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice.
Lee et al., Seoul, South Korea. In Curr Alzheimer Res, 2014
Moreover, gene profiling from microarray data using hippocampus of WT and Tg- 5xFAD following RF-EMF exposure revealed that 5 genes (Tshz2, Gm12695, St3gal1, Isx and Tll1), which are involved in Aβ, are significantly altered inTg-5xFAD mice, exhibiting different responses to RF-EMF in WT or Tg-5xFAD mice; RF-EMF exposure in WT mice showed similar patterns to control Tg-5xFAD mice, however, RF-EMF exposure in Tg- 5xFAD mice showed opposite expression patterns.
β-Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats.
Palou et al., Palma, Spain. In Mol Nutr Food Res, 2014
Both BC and RE supplementation increased retinoic acid mediated transcriptional responses in intestine (on Isx and Bco1) and the liver (on Cyp26a1 and Cpt1a).
Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry.
Lannigan et al., Charlottesville, United States. In Cytometry A, 2014
We decided to investigate whether the use of FCM combined with imaging, such as is possible with the ImagestreamX imaging FC (ISX), would be a more sensitive approach to characterizing MPs.
Nutrigenetics of carotenoid metabolism in the chicken: a polymorphism at the β,β-carotene 15,15'-mono-oxygenase 1 (BCMO1) locus affects the response to dietary β-carotene.
Duclos et al., France. In Br J Nutr, 2014
In the GG genotype, dietary β-carotene increased ISX (intestine-specific homeobox) and decreased BCMO1 mRNA levels in the duodenum, decreased xanthophyll concentrations in the duodenum, liver and plasma, and decreased colour index and HDL-cholesterol concentration in the plasma.
Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: a feasibility study.
Chérel et al., Saint-Herblain, France. In World J Gastroenterol, 2013
According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1; AKAP7; CAPN5; CLIC5; CPE; CREB3L1; NEDD4L; RAB27A), ion transport (AKAP7; ATP2A3; CCL28; CLIC5; F2RL2; NEDD4L; SLC6A8), transcription (AKAP7; CREB3L1; ISX; PABPC1L; TXNIP), signal transduction (CAPN5; F2RL2; RAB27A; TNFRSF11A), cell adhesion (ADAMDEC1; PXDN; SPON1; S100A2), immune response (CCL28; PXDN; TNFRSF11A) and apoptosis (ITM2C; PDCD4; PVT1).
Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
von Lintig et al., Cleveland, United States. In J Biol Chem, 2013
Here we show that the intestine-specific transcription factor ISX binds to the Bcmo1 promoter.
Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma.
Wang et al., Kao-hsiung, Taiwan. In Cancer Res, 2013
In this study, we compared the expression of interleukin (IL)-6 and cyclin D1 (CCND1) with the IL-6-induced homeobox gene ISX (intestine-specific homeobox) in 119 paired specimens of HCCs and adjacent normal tissues and also in paired specimens from 11 patients with non-HCCs.
Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule.
Eisch et al., Dallas, United States. In Faseb J, 2012
Previous work with a synthetic small molecule, isoxazole 9 (Isx-9), highlighted its neuronal-differentiating properties in vitro.
Coupling hippocampal neurogenesis to brain pH through proneurogenic small molecules that regulate proton sensing G protein-coupled receptors.
Zhang et al., Dallas, United States. In Acs Chem Neurosci, 2012
We recently tracked the function of our isoxazole stem cell-modulator small molecules (Isx) through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor with no known function in brain.
SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics.
Yasui et al., Edmonton, Canada. In Plos One, 2011
We found strong evidence of CD-association for 195 genes, identifying novel susceptibility genes (e.g., ISX, SLCO6A1, TMEM183A) as well as confirming many previously identified susceptibility genes in CD GWAS (e.g., IL23R, NOD2, CYLD, NKX2-3, IL12RB2, ATG16L1).
Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1).
Review
Rimbach et al., Newcastle upon Tyne, United Kingdom. In Arch Biochem Biophys, 2010
A diet-responsive regulatory network involving the intestine specific homeodomain transcription factor ISX has been shown to regulate the intestinal vitamin A uptake and production via a negative feedback control.
Basal body stability and ciliogenesis requires the conserved component Poc1.
GeneRIF
Winey et al., Boulder, United States. In J Cell Biol, 2010
Poc1B is required for primary ciliogenesis; Poc1 provides a molecular link between the assembly and stability of centrioles for ciliary-based motility in T. thermophila and cilia formation and function in zebrafish and humans
Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
GeneRIF
Seino et al., Kōbe, Japan. In J Biol Chem, 2008
Isx participates in the maintenance of vitamin A metabolism by regulating Bcmo1 expression in the intestine.
Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells.
GeneRIF
Fry et al., Leicester, United Kingdom. In Exp Cell Res, 2008
Based on these data, we propose that Pix1 and Pix2 are microtubule-associated adaptor proteins that likely contribute to a range of developmental and cell division processes.
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