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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Piwi-like 1

Piwi, Hiwi
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: Cdc4, CAN, 18 U, V1a, Dicer
Papers on Piwi
Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins.
New
Impact
Lin et al., New Haven, United States. In Nat Genet, Feb 2016
UNASSIGNED: The Drosophila melanogaster Piwi protein regulates both niche and intrinsic mechanisms to maintain germline stem cells, but its underlying mechanism remains unclear.
IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells.
New
Zhang et al., Guangzhou, China. In J Immunol, Feb 2016
UNASSIGNED: The discovery of PIWI-interacting RNAs (piRNAs) revealed the complexity of the RNA world.
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.
New
Pillai et al., Grenoble, France. In Mol Cell, Feb 2016
PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposons in the cytoplasm and nucleus of animal germ cells, but how silencing in the two compartments is coordinated is not known.
Antagonistic roles between Nibbler and Hen1 modulate piRNA 3' ends in Drosophila.
New
Liu et al., Shanghai, China. In Development, Jan 2016
Piwi-interacting RNAs of ∼23 to 30 nucleotides (nt) bound to PIWI-clade Argonaute proteins silence transposons strictly dependent on their sequence complementarity.
Computational identification of piRNA targets on mouse mRNAs.
New
He et al., Beijing, China. In Bioinformatics, Jan 2016
MOTIVATION: PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that are highly abundant in the germline.
Non-coding RNA in Spermatogenesis and Epididymal Maturation.
Review
New
McLaughlin et al., Newcastle, Australia. In Adv Exp Med Biol, Dec 2015
Testicular germ and somatic cells express many classes of small ncRNAs, including Dicer-independent PIWI-interacting RNAs, Dicer-dependent miRNAs, and endogenous small interfering RNA.
The piRNA Pathway Guards the Germline Genome Against Transposable Elements.
Review
New
Webster et al., Pasadena, United States. In Adv Exp Med Biol, Dec 2015
At the core of the piRNA pathway is a ribonucleoprotein complex consisting of a small RNA, called piRNA, and a protein from the PIWI subfamily of Argonaute nucleases.
Non-coding RNAs: An Introduction.
Review
New
Wilhelm et al., Australia. In Adv Exp Med Biol, Dec 2015
Since then many new classes of regulatory non-coding RNAs, including endogenous small interfering RNAs (endo-siRNAs), PIWI-associated RNAs (piRNAs), and long non-coding RNAs, have been identified and we have made amazing progress in elucidating their expression, biogenesis, mechanisms and mode of action, and function in many, if not all, biological processes.
Non-coding RNAs in Mammary Gland Development and Disease.
Review
New
Brown et al., Australia. In Adv Exp Med Biol, Dec 2015
NcRNAs include small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs).
Piwi-interacting RNAs in cancer: emerging functions and clinical utility.
New
Martinez et al., Vancouver, Canada. In Mol Cancer, Dec 2015
PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics.
RNA-based regulation of transposon expression.
Review
New
Rosenkranz et al., Mainz, Germany. In Wiley Interdiscip Rev Rna, Nov 2015
In the germline of animals, these tasks are often assumed by a second subclass of Argonaute proteins referred to as Piwi-like proteins, which bind a distinct class of small noncoding RNAs named piwi-interacting RNAs (piRNAs).
Panoramix enforces piRNA-dependent cotranscriptional silencing.
New
Impact
Hannon et al., United States. In Science, Nov 2015
The Piwi-interacting RNA (piRNA) pathway is a small RNA-based innate immune system that defends germ cell genomes against transposons.
Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production.
New
Impact
Zamore et al., Worcester, United States. In Science, Jun 2015
PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons.
PIWI-Interacting RNA: Its Biogenesis and Functions.
Review
Impact
Siomi et al., Tokyo, Japan. In Annu Rev Biochem, 2014
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24-31 nucleotides in length.
RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts.
Impact
Pillai et al., Grenoble, France. In Cell, 2014
Germline-specific Piwi-interacting RNAs (piRNAs) protect animal genomes against transposons and are essential for fertility.
PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53.
GeneRIF
Tang et al., Tianjin, China. In Febs Lett, 2012
PIWIL4 might play an oncogenic role in cervical cancer
Combined phenotype of 4 markers improves prognostic value of patients with colon cancer.
GeneRIF
Shou et al., Beijing, China. In Am J Med Sci, 2012
A subgroup of more aggressive tumors can be identified by evaluating Hiwi level in lymph node metastatic cancer.
Hiwi mediated tumorigenesis is associated with DNA hypermethylation.
GeneRIF
Matushansky et al., New York City, United States. In Plos One, 2011
Hiwi-associated DNA hyper-methylation with subsequent genetic and epigenetic changes favors a tumorigenic state
The PIWI protein acts as a predictive marker for human gastric cancer.
GeneRIF
Gao et al., Shanghai, China. In Int J Clin Exp Pathol, 2011
Expression of PIWIL1 was an independent prognostic factor in gastric cancer.
[The role of piRNA and Piwi proteins in regulation of germline development].
Review
GeneRIF
Wrzesiński et al., Poznań, Poland. In Postepy Biochem, 2010
In this review, the current state of knowledge on the structure, biogenesis and function of piRNA and their interactions with Piwi proteins is presented.
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