Bacterial protein toxins in human cancers.
Roma, Italy. In Pathog Dis, Feb 2016
Some toxins, like CDT and colibactin, directly attack the genome by damaging DNA whereas others, as for example CNF1, CagA and BFT, impinge on key eukaryotic processes, such as cellular signalling and cell death.
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
Japan. In J Reprod Dev, Jan 2016
Reporter assays for another 39 factors using the 3 kb upstream regions in CHO cells ultimately revealed that 8 factors, MSX2, PAX6, PIT1, PITX1, PITX2, RPF1, SOX8 and SOX11, but not RBP-J, regulate Prop1 expression.
Etiopathogenesis of equinovarus foot malformations.
Houston, United States. In Eur J Med Genet, 2014
So far a handful of genes involved in limb patterning like PITX1, HOXA, HOXD, TBX4, and RBM10, as well as genes involved in muscle contraction, have been identified as possible players.