Deregulated Renal Calcium and Phosphate Transport during Experimental Kidney Failure.
Nijmegen, Netherlands. In Plos One, 2014
Furthermore, kidney failure was characterized by enhanced renal expression of the transient receptor potential cation channel subfamily V member 5 (TRPV5), calbindin-D28k, and sodium-dependent Pi transporter type 2b (NaPi2b), whereas the renal expression of sodium-dependent Pi transporter type 2a (NaPi2a) and type 3 (PIT2) were reduced.
Genetic diseases of renal phosphate handling.
Zürich, Switzerland. In Nephrol Dial Transplant, 2014
At least three transport proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1), NAPI-IIc (SLC34A3) and PIT-2 (SLC20A2).
An update on primary familial brain calcification.
Santiago de Compostela, Spain. In Int Rev Neurobiol, 2012
Recently, mutations in the SLC20A2 gene coding for the inorganic phosphate transporter PiT2 were linked to PFBC, thereby implicating impaired phosphate transport as an underlying disease mechanism.