gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

POU class 1 homeobox 1

Pit-1, GHF-1, POU1F1
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Prolactin, CAN, HAD, ACID, Lhx3
Papers on Pit-1
MECHANISMS IN ENDOCRINOLOGY: AN UPDATE IN THE GENETIC AETIOLOGIES OF COMBINED PITUITARY HORMONE DEFICIENCY.
Review
New
Brue et al., Marseille, France. In Eur J Endocrinol, Feb 2016
Taking into account the fact that several reviews have been published in recent years on classical aetiologies of CPHD such as mutations of POU1F1 or PROP1, we focused the present overview on the data published in the last 5 years, to provide the reader with an updated review on this rapidly evolving field of knowledge.
Delayed Adrenarche May Be an Additional Feature of IGSF1 Deficiency Syndrome.
New
Schepper et al., In J Clin Res Pediatr Endocrinol, Jan 2016
Brain MRI and PROP1 and POU1F1 sequencing were normal.
Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene.
New
Kato et al., Japan. In J Reprod Dev, Jan 2016
UNASSIGNED: Pituitary-specific transcription factor PROP1, a factor important for pituitary organogenesis, appears on rat embryonic day 11.5 (E11.5) in SOX2-expressing stem/progenitor cells and always coexists with SOX2 throughout life.
Recent advances in central congenital hypothyroidism.
Review
New
Dattani et al., London, United Kingdom. In J Endocrinol, Dec 2015
Genetic ascertainment is possible in a minority of cases and reveals mutations in genes controlling the TSH biosynthetic pathway (TSHB, TRHR, IGSF1) in isolated TSH deficiency, or early (HESX1, LHX3, LHX4, SOX3, OTX2) or late (PROP1, POU1F1) pituitary transcription factors in combined hormone deficits.
Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.
New
Amselem et al., Paris, France. In Hum Mol Genet, Dec 2015
UNASSIGNED: POU1F1, a pituitary-specific POU-homeo domain transcription factor, plays an essential role in the specification of the somatotroph, lactotroph and thyrotroph lineages and in the activation of GH1, PRL and TSHβ transcription.
Two coexisting heterozygous frameshift mutations in PROP1 are responsible for a different phenotype of combined pituitary hormone deficiency.
New
Ruchała et al., Poznań, Poland. In J Appl Genet, Dec 2015
The major contributors are the PROP1, POU1F1, LHX3, LHX4 and HESX1 genes coding transcription factors implicated in pituitary organogenesis.
The role of ANKH in pathologic mineralization of cartilage.
New
Williams, Camden, United States. In Curr Opin Rheumatol, Dec 2015
ANKH appears to interact with several cellular proteins, including the phosphate transporter PiT-1, and with proteins involved in NF-kappa β signaling, suggesting that ANKH may play an important non-PPi transporter role.
[A Novel Clinical Entity "Anti-PIT-1 Antibody Syndrome"--Autoimmunity against a Transcription Factor].
Review
New
Iguchi et al., In Rinsho Byori, Apr 2015
Recently, a unique autoantibody against pituitary transcription factor PIT-1 (POU1F1) was detected in patients with an acquired combined pituitary hormone deficiency characterized by a specific defect in growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH).
Anti-PIT-1 antibody syndrome; a novel clinical entity leading to hypopituitarism.
Review
New
Takahashi et al., In Pediatr Endocrinol Rev, Mar 2015
Anti-PIT-1 (pituitary-specific transcription factor 1) antibody syndrome is a novel clinical entity that presents an acquired combined pituitary hormone deficiency characterized by a specific defect in growth hormone, prolactin, and thyroid-stimulating hormone.
Genetic Defects in Thyroid Hormone Supply
Review
Macchia et al., Madagascar. In Unknown Journal, 2015
This situation can be determined by alterations in genes involved in ontogeny of the thyroid, including PIT1 and PRPO1, HESX1, LHX3, LHX4 and SOX3 as well as by mutation in the TSH-beta or in the immunoglobulin superfamily member 1 (IGSF1) genes.
Required enhancer-matrin-3 network interactions for a homeodomain transcription program.
Impact
Rosenfeld et al., San Diego, United States. In Nature, 2014
Here investigation of a developmentally required POU-homeodomain transcription factor, Pit1 (also known as Pou1f1), has revealed that, unexpectedly, binding of Pit1-occupied enhancers to a nuclear matrin-3-rich network/architecture is a key event in effective activation of the Pit1-regulated enhancer/coding gene transcriptional program.
PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis.
GeneRIF
Fedele et al., Napoli, Italy. In Endocr Relat Cancer, 2012
Expression analysis of HMGA1, HMGA2 and PIT1 in human pituitary adenomas of different histological types revealed a direct correlation between PIT1 and HMGA expression levels.
Effect of polymorphic variants of GH, Pit-1, and beta-LG genes on milk production of Holstein cows.
GeneRIF
Zerehdaran et al., Gorgān, Iran. In Genetika, 2012
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 gene (AB) was desirable
POU1F1-mediated activation of hGH-N by deoxyribonuclease I hypersensitive site II of the human growth hormone locus control region.
GeneRIF
Shewchuk et al., Greenville, United States. In J Mol Biol, 2012
HSII confers robust POU1F1-dependent activation of hGH-N in this system.
[Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Holstein cattle].
GeneRIF
Zhong et al., Jinan, China. In Yi Chuan, 2011
results showed that GC genotype at 1178 locus of POU1F1 gene was advantageous for milk yield, milk protein yield, and milk fat yield
CEBPD suppresses prolactin expression and prolactinoma cell proliferation.
GeneRIF
Melmed et al., Los Angeles, United States. In Mol Endocrinol, 2011
CEBPD and Pit1 interact and attenuate each other's binding to the PRL promoter.
Mutations in PROP1 cause familial combined pituitary hormone deficiency.
Impact
Rosenfeld et al., San Diego, United States. In Nat Genet, 1998
Mutations of the pituitary transcription factor gene POU1F1 (the human homologue of mouse Pit1) are responsible for deficiencies of GH, prolactin and thyroid stimulating hormone (TSH) in Snell and Jackson dwarf mice and in man, while the production of adrenocorticotrophic hormone (ACTH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) is preserved.
The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein.
Impact
Karin et al., San Diego, United States. In Cell, 1988
Growth hormone factor 1 (GHF-1) is a pituitary-specific transcription factor that plays a critical role in cell type-specific expression of the growth hormone (GH) gene.
Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1.
Impact
Karin et al., San Diego, United States. In Cell, 1988
Growth hormone (GH) expression in pituitary-derived cells has been attributed to the presence of a positive trans-activator, GHF-1, which binds to two sites on the GH promoter.
A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells.
Impact
Karin et al., In Cell, 1987
These cell lines also contain a specific factor, GHF-1, that binds to two sites upstream to the hGH TATA box.
share on facebooktweetadd +1mail to friends