Visualization of host-polerovirus interaction topologies using Protein Interaction Reporter technology.
Seattle, United States. In J Virol, Jan 2016
Using infectious preparations of a polerovirus (Potato leafroll virus, PLRV) and Protein Interaction Reporter (PIR), a revolutionary technology that couples a mass spectrometric-cleavable chemical cross-linker with high resolution mass spectrometry, we provide the first report of any host-pathogen protein interaction network that includes data-derived, topological features for every cross-linked site that was identified.
A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.
Oklahoma City, United States. In Clin Rev Allergy Immunol, Dec 2015
DAP12 pairs with a number of different immunoreceptors including triggering receptor expressed on myeloid cells 2 (TREM2), myeloid DAP12-associated lectin (MDL-1), and sialic acid-binding immunoglobulin-type lectin 15 (Siglec-15); while FcRγ pairs with a different set of receptors including osteoclast-specific activating receptor (OSCAR), paired immunoglobulin receptor A (PIR-A), and Fc receptors.
Role of inhibitory BCR co-receptors in immunity.
Tokyo, Japan. In Infect Disord Drug Targets, 2012
B lymphocytes (B cells) express a variety of membrane molecules containing immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region such as FcγRIIB, FCRLs, CD22, mouse Siglec-G/human Siglec-10, PECAM-1, mouse PIR-B/human LIRB1 and LIRB2PD-1 and CD72.
[Mast cell inhibitory receptors].
Łódź, Poland. In Postepy Hig Med Dosw (online), 2011
The scope of this paper is to present the current knowledge on mast cell-associated inhibitory receptors, such as FcγRIIB, paired immunoglobulin-like receptor B (PIR-B), CD300, CD172a, gp49B1, CD200R, sialic acid-binding immunoglobulin-like lectin (Siglec) molecules, CD305, allergin-1, mast cell function-associated antigen (MAFA), and CD72.
Fetuin-A: a multifunctional protein.
Ōsaka, Japan. In Recent Pat Endocr Metab Immune Drug Discov, 2011
Fetuin, first isolated from fetal bovine serum and now most commonly known as either fetuin-A, alpha-2-HS-glycoprotein (recommended name by UniprotKB and PIR), or α2-Heremans-Schmid glycoprotein, functions as an important component of diverse normal and pathological processes, including vascular calcification and bone metabolism regulation, insulin resistance, protease activity control, keratinocytes migration, and breast tumor cell proliferative signaling.
Role of PIR-B in autoimmune glomerulonephritis.
Sendai, Japan. In J Biomed Biotechnol, 2010
PIR-B, an inhibitory receptor expressed on murine B cells and myeloid cells, regulates humoral and cellular immune responses via its constitutive binding to the ligand, MHC class I molecules, on the same cells (cis) or on different cells (trans).