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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, fibrillin-1
Papers on PIR
Visualization of host-polerovirus interaction topologies using Protein Interaction Reporter technology.
Cilia et al., Seattle, United States. In J Virol, Jan 2016
Using infectious preparations of a polerovirus (Potato leafroll virus, PLRV) and Protein Interaction Reporter (PIR), a revolutionary technology that couples a mass spectrometric-cleavable chemical cross-linker with high resolution mass spectrometry, we provide the first report of any host-pathogen protein interaction network that includes data-derived, topological features for every cross-linked site that was identified.
Accurate estimation of isoelectric point of protein and peptide based on amino acid sequences.
Perez-Riverol et al., Havana, Cuba. In Bioinformatics, Dec 2015
CONTACT: and Implementation: The software and data are freely available at
A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.
Nakamura et al., Oklahoma City, United States. In Clin Rev Allergy Immunol, Dec 2015
DAP12 pairs with a number of different immunoreceptors including triggering receptor expressed on myeloid cells 2 (TREM2), myeloid DAP12-associated lectin (MDL-1), and sialic acid-binding immunoglobulin-type lectin 15 (Siglec-15); while FcRγ pairs with a different set of receptors including osteoclast-specific activating receptor (OSCAR), paired immunoglobulin receptor A (PIR-A), and Fc receptors.
Insulin-related signaling pathways elicited by light in photoreceptor nuclei from bovine retina.
Giusto et al., Bahía Blanca, Argentina. In Exp Eye Res, Dec 2015
In PNF obtained from bovine retinas exposed to light or darkness, the presence of insulin receptor (IR) and phosphorylated insulin receptor (pIR), the activation of Akt, p38 and extracellular signal-regulated kinase (ERK1/2) and the local action of insulin on lipid kinases were studied.
Spatio-Temporal Constrained Human Trajectory Generation from the PIR Motion Detector Sensor Network Data: A Geometric Algebra Approach.
Lv et al., Nanjing, China. In Sensors (basel), 2014
Passive infrared (PIR) motion detectors, which can support long-term continuous observation, are widely used for human motion analysis.
The contribution of Pir protein family to yeast cell surface display.
Qiao et al., Kunming, China. In Appl Microbiol Biotechnol, 2014
Proteins with internal repeats (Pir) in the Baker's yeast are located on the cell wall and include four highly homologous members.
Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.
Munitz et al., Tel Aviv-Yafo, Israel. In Nat Immunol, 2014
Here we demonstrate that IL-5 activity in eosinophils was regulated by paired immunoglobulin-like receptors PIR-A and PIR-B.
Role of inhibitory BCR co-receptors in immunity.
Tsubata, Tokyo, Japan. In Infect Disord Drug Targets, 2012
B lymphocytes (B cells) express a variety of membrane molecules containing immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region such as FcγRIIB, FCRLs, CD22, mouse Siglec-G/human Siglec-10, PECAM-1, mouse PIR-B/human LIRB1 and LIRB2PD-1 and CD72.
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome.
Tassone et al., New York City, United States. In Genes Brain Behav, 2012
Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP interactor, is detected in fragile X syndrome.
Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis.
Weil et al., Tel Aviv-Yafo, Israel. In Dis Markers, 2011
blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 compared to the levels of expression in control subjects.
[Mast cell inhibitory receptors].
Brzezińska-Błaszczyk et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2011
The scope of this paper is to present the current knowledge on mast cell-associated inhibitory receptors, such as FcγRIIB, paired immunoglobulin-like receptor B (PIR-B), CD300, CD172a, gp49B1, CD200R, sialic acid-binding immunoglobulin-like lectin (Siglec) molecules, CD305, allergin-1, mast cell function-associated antigen (MAFA), and CD72.
Pirin inhibits cellular senescence in melanocytic cells.
Alcalay et al., Milano, Italy. In Am J Pathol, 2011
pirin may have a relevant role in melanoma progression.
Fetuin-A: a multifunctional protein.
Inaba et al., Ōsaka, Japan. In Recent Pat Endocr Metab Immune Drug Discov, 2011
Fetuin, first isolated from fetal bovine serum and now most commonly known as either fetuin-A, alpha-2-HS-glycoprotein (recommended name by UniprotKB and PIR), or α2-Heremans-Schmid glycoprotein, functions as an important component of diverse normal and pathological processes, including vascular calcification and bone metabolism regulation, insulin resistance, protease activity control, keratinocytes migration, and breast tumor cell proliferative signaling.
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
Chen et al., New York City, United States. In Immunity, 2011
Herein, we investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also known as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation, and its role in tumor-induced immunity.
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
Rustgi et al., Philadelphia, United States. In Cancer Res, 2011
Studies identify a novel proapoptotic gene target, CYFIP2, which is downregulated by IMP-1, and mediates the regulation of cell survival and K-Ras expression in colon cancer cells.
Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice.
Kruszewski et al., Warsaw, Poland. In Redox Rep, 2010
Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain.
Role of PIR-B in autoimmune glomerulonephritis.
Endo et al., Sendai, Japan. In J Biomed Biotechnol, 2010
PIR-B, an inhibitory receptor expressed on murine B cells and myeloid cells, regulates humoral and cellular immune responses via its constitutive binding to the ligand, MHC class I molecules, on the same cells (cis) or on different cells (trans).
Resistance to therapy caused by intragenic deletion in BRCA2.
Ashworth et al., London, United Kingdom. In Nature, 2008
We derived PARP-inhibitor-resistant (PIR) clones from the human CAPAN1 pancreatic cancer cell line, which carries the protein-truncating c.6174delT frameshift mutation.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
Mello et al., Worcester, United States. In Cell, 2006
One interactor, the conserved RNA-phosphatase homolog PIR-1, is required for the processing of a putative amplified DCR-1 substrate.
The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
Lowell et al., San Francisco, United States. In Immunity, 2005
These kinases may mediate their effect through the inhibitory receptor PIR-B since neutrophils and DCs from pir-b-/- mice were also hyperresponsive to chemokine stimulation.
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