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Inositol polyphosphate-5-phosphatase J

PIPP, inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase, inositol polyphosphate 5-phosphatase 2
hydrolyzes phosphate at the D-5 position of inositol or phosphatidylinositol polyphosphates; may mediate the level of inositol and phosphatidylinositol polyphosphates at membrane ruffles [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, SHIP, ACID, SHIP2, Src
Papers on PIPP
Brevis plant1, a putative inositol polyphosphate 5-phosphatase, is required for internode elongation in maize.
Lukens et al., Guelph, Canada. In J Exp Bot, Feb 2016
We found that an inositol polyphosphate 5-phosphatase orthologue of the rice gene dwarf50 was the molecular basis for the bv1 phenotype, implicating auxin-mediated inositol polyphosphate and/or phosphoinositide signalling in stem elongation.
The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.
Mitchell et al., Australia. In Cancer Cell, Sep 2015
Here, we show depletion of the inositol polyphosphate 5-phosphatase PIPP (INPP5J) increases breast cancer cell transformation, but reduces cell migration and invasion.
Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.
Schiffmann et al., Brussels, Belgium. In Dev Cell, Sep 2015
Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown.
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1.
Vargas-Poussou et al., Paris, France. In Hum Mutat, Aug 2015
Two genetic subtypes have been described to date: Dent disease 1 is caused by mutations of the CLCN5 gene, coding for the chloride/proton exchanger ClC-5; and Dent disease 2 by mutations of the OCRL gene, coding for the inositol polyphosphate 5-phosphatase OCRL-1.
INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability.
Smyth et al., Australia. In J Cell Sci, Feb 2015
Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood.
Nephrolithiasis, kidney failure and bone disorders in Dent disease patients with and without CLCN5 mutations.
Dent Disease Italian Network et al., Padova, Italy. In Springerplus, 2014
CLCN5 encodes the electrogenic chloride/proton exchanger ClC-5 which is involved in the tubular reabsorption of albumin and LMW proteins, OCRL encodes the inositol polyphosphate 5-phosphatase, and was initially associated with Lowe syndrome.
PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.
Cowell et al., Birmingham, United States. In J Neurosci, 2014
We observed bidirectional regulation of novel PGC-1α-dependent transcripts spanning synaptic [synaptotagmin 2 (Syt2) and complexin 1 (Cplx1)], structural [neurofilament heavy chain (Nefh)], and metabolic [neutral cholesterol ester hydrolase 1 (Nceh1), adenylate kinase 1 (Ak1), inositol polyphosphate 5-phosphatase J (Inpp5j), ATP synthase mitochondrial F1 complex O subunit (Atp5o), phytanol-CoA-2hydroxylase (Phyh), and ATP synthase mitrochondrial F1 complex α subunit 1 (Atp5a1)] functions.
Myo-inositol and beyond--emerging networks under stress.
Van den Ende et al., Montpellier, France. In Plant Sci, 2011
Importantly, myo-inositol polyphosphate 5-phosphatase (5PTase) acts, depending on sugar status, as a positive or negative regulator of a global energy sensor, SnRK1.
Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.
Mitchell et al., Australia. In J Biol Chem, 2011
PIPP and CRMP2 exert opposing roles in promoting axon selection and neurite elongation and the complex between these proteins serves to regulate the localization of effectors that promote neurite extension.
Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial.
Fitzgerald et al., Oxford, United Kingdom. In Lancet, 2010
Secondary measures were baseline behavioural and physiological measures, observational pain scores (PIPP), and spinal nociceptive reflex withdrawal activity.
A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity.
Orth et al., Dallas, United States. In Science, 2010
We found that VPA0450 is an inositol polyphosphate 5-phosphatase that hydrolyzed the D5 phosphate from the plasma membrane phospholipid phosphatidylinositol 4,5-bisphosphate.
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease.
Mitchell et al., Australia. In Biochem J, 2009
Futhermore, the 5-ptases SHIP [SH2 (Src homology 2)-domain-containing inositol phosphatase] 2, SKIP (skeletal muscle- and kidney-enriched inositol phosphatase) and 72-5ptase (72 kDa 5-ptase)/Type IV/Inpp5e (inositol polyphosphate 5-phosphatase E) are implicated in negatively regulating insulin signalling and glucose homoeostasis in specific tissues.
Phosphoinositide phosphatases in a network of signalling reactions.
Erneux et al., Brussels, Belgium. In Pflugers Arch, 2007
Another family consists of the inositol polyphosphate 5-phosphatase isoenzymes.
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
Pendergast et al., Durham, United States. In Nat Cell Biol, 2003
Decreasing cellular levels of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PLC-gamma1-mediated hydrolysis or dephosphorylation by an inositol polyphosphate 5-phosphatase (Inp54) results in increased Abl kinase activity.
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Hannan et al., Melbourne, Australia. In J Biol Chem, 2002
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.
Blundell et al., Cambridge, United Kingdom. In J Mol Biol, 2002
crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy
Lowe Syndrome
Brewer et al., Seattle, United States. In Unknown Journal, 2001
DIAGNOSIS/TESTING: Lowe syndrome is caused by markedly reduced activity of an inositol polyphosphate 5-phosphatase OCRL-1, which is encoded by OCRL.
Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase.
Hurley et al., Bethesda, United States. In Cell, 2001
The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling those of several Mg(2+)-dependent nucleases.
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