PIP5KI gamma is required for cardiovascular and neuronal development.
Philadelphia, United States. In Proc Natl Acad Sci U S A, 2007
Type I phosphatidylinositol-4-phosphate 5-kinase (PIP5KI) isoforms have overlapping, but not completely redundant, functions within cells; targeted disruption of PIP5KIgamma causes widespread developmental and cellular defects.
Dynamin at actin tails.
New Haven, United States. In Proc Natl Acad Sci U S A, 2002
Here we show that endogenous dynamin 2, as well as green fluorescence protein fusion proteins of both dynamin 1 and 2, is present in actin comets generated by Listeria or by type I PIP kinase (PIPK) overexpression.
Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid.
Madison, United States. In J Biol Chem, 1994
Based on functional studies, the 68-kDa protein is indistinguishable from the type I PIP kinase previously characterized from human erythrocyte membranes (Bazenet, C. E., Ruano, A.R., Brockman, J.L., and Anderson, R.A. (1990) J. Biol.