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Phosphatidylinositol-5-phosphate 4-kinase, type II, beta

PIP5K2B, pip4Kiibeta, PIP5KIIbeta
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Lasp-1, SIMPLE, MACF1, MC3R, Rhodopsin
Papers on PIP5K2B
Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta.
Schaefer et al., Frankfurt am Main, Germany. In Biochem Biophys Res Commun, 2014
Phosphatidylinositol-5-phosphate 4-kinase, type II, beta (PIP5K2B) is linked to the pathogenesis of obesity, insulin resistance and diabetes.
Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells.
Fukami et al., Hachiƍji, Japan. In Biochem Biophys Res Commun, 2011
These results indicate that PIPKIIbeta-mediated PI(4,5)P(2) signaling is important for E-cadherin upregulation and inhibition of cellular motility induced by VDR activation.
High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.
Powell et al., The Woodlands, United States. In Obesity (silver Spring), 2008
below the mean for seven (perilipin, SCD1, CB1, MCH1R, PTP1B, GPAT1, PIP5K2B) but close to the mean for NPY Y4R.
Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.
Irvine et al., Cambridge, United Kingdom. In Cell Signal, 2007
PIPkin IIbeta is expressed as a tagged protein, is active as revealed by immunoprecipitation and enzyme assay, and that cellular fractionation reveals that it is indeed nuclear.
Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.
Delattre et al., Paris, France. In Oncogene, 2005
Indeed, the 3'UTR of the PIP5K2B gene on chromosome 17q is directly fused to the (TTAGGG)n repeat of the chromosome 4p telomere, and the (1;4) fusion disrupts the MACF1 (microtubule-actin crosslinking factor 1) and POLN genes, respectively.
Identification and characterization of human ARHGAP23 gene in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
ARHGAP23-KIAA1684-MLLT6-RNF110-PIP5K2B-LASP1-PLXDC1-CACNB1 locus at human chromosome 17q12 and CACNB2-PLXDC2-LASP2-MLLT10-BMI1-PIP5K2A-KIAA1217-ARHGAP21 locus at human chromosome 10p12 were paralogous regions (paralogons) with internal inversion.
Targets of gene amplification and overexpression at 17q in gastric cancer.
El-Rifai et al., Helsinki, Finland. In Cancer Res, 2002
Analysis of DNA copy number changes by comparative genomic hybridization on cDNA microarray revealed increased copy numbers of 11 known genes (ERBB2, TOP2A, GRB7, ACLY, PIP5K2B, MPRL45, MKP-L, LHX1, MLN51, MLN64, and RPL27) and seven expressed sequence tags (ESTs) that mapped to 17q12-q21 region.
Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.
Kratochwil et al., Salzburg, Austria. In Cytogenet Genome Res, 2001
located within a 185-kb contig surrounding a transgene on chromosome 11
A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase.
Chao et al., New York City, United States. In J Biol Chem, 1997
In vitro experiments using recombinant fusion proteins verify the authenticity of the interaction between the p55 receptor and PIP5KIIbeta, a new isoform of PIP5K, but not the previously identified 53-kDa PIP5KIIalpha.
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