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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

PIP5K2A, phosphatidylinositol-4-phosphate 5-kinase IIalpha, PIP5KII
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on PIP5K2A
Expression of PIP4K2A in lymphocyte cell lines from a sample of schizophrenia patients with previous evidence for association.
Schwab et al., In Schizophr Res, 2011
The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
Divecha et al., Manchester, United Kingdom. In Biochem J, 2010
PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha.
Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.
Bitter et al., Budapest, Hungary. In Am J Med Genet B Neuropsychiatr Genet, 2010
A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome.
Sørlie et al., Oslo, Norway. In Plos One, 2009
Studies indicate that the gene PIP5K2A was significantly elevated in stroma cells in distant metastasis group, compared to stroma in no distant metastasis group.
PIP4KIIA and beta-globin: transcripts differentially expressed in reticulocytes and associated with high levels of Hb H in two siblings with Hb H disease.
Sonati et al., Campinas, Brazil. In Eur J Haematol, 2009
PIP4KIIA may be one of the factors related to the regulation of the beta-globin gene expression and the different levels of Hb H in alpha-thalassemic patients
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