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PIN2/TERF1 interacting, telomerase inhibitor 1

PinX1, TRF1-interacting protein, LPTS
Top mentioned proteins: TRF1, CAN, TIN2, TRF2, Thymopentin
Papers on PinX1
Novel role for PINX1 as a coregulator of nuclear hormone receptors.
Langley et al., Mexico. In Mol Cell Endocrinol, Nov 2015
This work shows that Pin2 interacting protein 1 (PINX1) interacts with the N-terminal domain of ERα and functions as a corepressor of ERα.
Increased Stability of Nucleolar PinX1 in the Presence of TERT.
Oh et al., Seoul, South Korea. In Mol Cells, Sep 2015
PinX1, a nucleolar protein of 328 amino acids, inhibits telomerase activity, which leads to the shortening of telomeres.
PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription.
Zheng et al., Nanjing, China. In Oncotarget, Sep 2015
PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) is a novel cloned gene which has been identified as a major haploinsufficient tumor suppressor essential for maintaining telomerase activity, the length of telomerase and chromosome stability.
Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy.
Zhang et al., Zhengzhou, China. In Biomed Pharmacother, Jul 2015
Previous studies suggest that Pin2/TRF1 interacting protein X1 (PinX1) is an intrinsic telomerase inhibitor and a putative tumor suppressor gene in human cancers.
[Influence and mechanism of PinX1 gene on the chemotherapy sensitivity of nasopharyngeal carcinoma cells in response to Cisplatin].
Zhang et al., Guangzhou, China. In Zhonghua Yi Xue Za Zhi, Jul 2015
OBJECTIVE: To explore the influence and mechanism of PinX1 gene on the chemotherapy sensitivity of nasopharyngeal carcinoma cells in response to Cisplatin.
Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study.
Mei et al., New Orleans, United States. In Gene, Jun 2015
RESULTS: Marker rs7840785 (PINX1) was significantly associated with right carotid IMT (p=0.0003) using all participants; mean levels for the CC, TC, and TT genotypes were 0.74 (0.73 to 0.75), 0.76 (0.75 to 0.78), and 0.78 (0.75, 0.81), respectively.
PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-κB/MMP-9 signaling pathway.
Zheng et al., Xuzhou, China. In Mol Cancer, 2014
BACKGROUND: PinX1 (PIN2/TRF1-interacting telomerase inhibitor 1) was suggested to be correlated with tumor progression.
Suppression of PinX1 resulted in telomere dysfunction and enhanced radiosensitivity in osteosarcoma cell lines.
Gao et al., In Neoplasma, 2014
Pin2/TRF1 interacting protein X1 (PinX1) is an intrinsic telomerase inhibitor and a putative tumor suppressor gene in human cancers.
LPTS: A Novel Tumor Suppressor Gene and a Promising Drug Target for Cancer Intervention.
Liu et al., Chongqing, China. In Recent Pat Anticancer Drug Discov, 2014
Liver-related putative tumor suppressor (lpts) is a liver-related tumor suppressor candidate gene initially isolated by positional candidate cloning method.
PinX1 is up-regulated and associated with poor patients' survival in gliomas.
Zheng et al., Xuzhou, China. In Int J Clin Exp Pathol, 2014
PinX1, a conserved nuclear protein, could maintain telomere integrity and plays an important role in regulating telomerase activity.
PinX1 localizes to telomeres and stabilizes TRF1 at mitosis.
Counter et al., Durham, United States. In Mol Cell Biol, 2012
one function of PinX1 is to stabilize TRF1 during mitosis, perhaps to promote transition into M phase of the cell cycle.
PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells.
Wang et al., Guangzhou, China. In J Exp Clin Cancer Res, 2011
PinX1 may play important roles in NPC proliferation, migration and apoptosis and has application potential in tumor-targeted gene therapy
Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation.
Zhou et al., Boston, United States. In J Biol Chem, 2011
the telomerase inhibitor PinX1 is recruited to telomeres by TRF1 and provides a critical link between TRF1 and telomerase inhibition to prevent telomere elongation and help maintain telomere homeostasis.
Plk1-mediated mitotic phosphorylation of PinX1 regulates its stability.
Huang et al., Hangzhou, China. In Eur J Cell Biol, 2010
Polo-like kinase 1 (Plk1) is a novel interacting protein of PinX1 and may negatively regulate the stability of PinX1 by mitotic phosphorylation.
C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition.
Zhao et al., Shanghai, China. In Biochem Biophys Res Commun, 2010
these results suggest that the C-terminal fragment of LPTS/PinX1 (LPTS/PinX1(290-328)) contains a telomerase inhibitory domain that is required for the inhibition of telomere elongation and the induction of cell crisis.
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Lei et al., Ann Arbor, United States. In Science, 2008
Conversely, the TRFH domain of TRF1, but not of TRF2, interacts with another shelterin-associated factor: PinX1.
PTOP interacts with POT1 and regulates its localization to telomeres.
Songyang et al., Houston, United States. In Nat Cell Biol, 2004
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12).
Polypeptide components of telomere nucleoprotein complex.
Kuimov, Moscow, Russia. In Biochemistry (mosc), 2004
The telomere nucleoprotein complex also interacts with various polypeptide macromolecules (e.g., Sir2, PinX1, Rap1, Ku, Rad50/Mre11/Nbs1) responsible for heterochromatin formation, modulation of telomerase activity, DNA repair, and signaling to other cell compartments about telomere state.
POT1 as a terminal transducer of TRF1 telomere length control.
De Lange et al., New York City, United States. In Nature, 2003
Human telomere length is regulated by the TTAGGG-repeat-binding protein TRF1 and its interacting partners tankyrase 1, TIN2 and PINX1 (refs 5-9).
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.
Lu et al., Boston, United States. In Cell, 2001
Here we describe a novel Pin2/TRF1 binding protein, PinX1 that inhibits telomerase activity and affects tumorigenicity.
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