PTOP interacts with POT1 and regulates its localization to telomeres.
Houston, United States. In Nat Cell Biol, 2004
Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (refs 1-12).
Polypeptide components of telomere nucleoprotein complex.
Moscow, Russia. In Biochemistry (mosc), 2004
The telomere nucleoprotein complex also interacts with various polypeptide macromolecules (e.g., Sir2, PinX1, Rap1, Ku, Rad50/Mre11/Nbs1) responsible for heterochromatin formation, modulation of telomerase activity, DNA repair, and signaling to other cell compartments about telomere state.