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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G-protein signaling modulator 2

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: CAN, Insulin, FATE, NuMA, V1a
Papers on Pins
Warts Phosphorylates Mud to Promote Pins-Mediated Mitotic Spindle Orientation in Drosophila, Independent of Yorkie.
Johnston et al., Albuquerque, United States. In Curr Biol, Dec 2015
Here, we describe a role for the Hippo (Hpo) kinase complex in promoting Partner of Inscuteable (Pins)-mediated spindle orientation.
Silver/silver chloride microneedles can detect penetration through the round window membrane.
Lalwani et al., New York City, United States. In J Biomed Mater Res B Appl Biomater, Nov 2015
METHODS: 0.2 mm diameter stainless steel Minutien pins were electroplated with copper, then silver.
Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling.
Zallen et al., New York City, United States. In Dev Cell, Nov 2015
Spitz orients cell divisions through a Pins/LGN-dependent spindle-positioning mechanism and controls cell shape and alignment through a transcriptional pathway that requires the Pointed ETS domain protein.
Mode of interaction of the Gαo subunit of heterotrimeric G proteins with the GoLoco1 motif of Drosophila Pins is determined by guanine nucleotides.
Katanaev et al., Lausanne, Switzerland. In Biosci Rep, 2014
Drosophila GoLoco motif-containing protein Pins is unusual in its highly efficient interaction with both GDP- and the GTP-loaded forms of the α-subunit of the heterotrimeric Go protein.
Overcoming the Rare Event Sampling Problem in Biological Systems with Infinite Swapping.
Meuwly et al., Berlin, Germany. In J Chem Theory Comput, 2013
For these three test systems, PINS is compared to PT, and it is found that in all cases the sampling with PINS is substantially more efficient.
Epithelial polarity and spindle orientation: intersecting pathways.
St Johnston et al., Cambridge, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, 2012
Work in the past 20 years has defined a core ternary complex consisting of Pins, Mud and Gαi that participates in spindle orientation in both asymmetric and symmetric divisions.
The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.
Martin et al., Houston, United States. In Biochem J, 2012
Overexpression of LGN decreases the activity of cellular sGC, whereas knockdown of LGN mRNA and protein correlated with increased sGC activity
GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome.
Zelinski et al., Seattle, United States. In Am J Hum Genet, 2012
GPSM2 is required for orienting the mitotic spindle during cell division in multiple tissues, suggesting that the sensorineural hearing loss and characteristic brain malformations of CMS are due to defects in asymmetric cell divisions during development
Inscuteable regulates the Pins-Mud spindle orientation pathway.
Prehoda et al., Eugene, United States. In Plos One, 2011
Insc-Pins complex requires Galphai for partial activity and that the complex specifically recruits Dlg but not Mud.
Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).
Sumimoto et al., Fukuoka, Japan. In Proc Natl Acad Sci U S A, 2011
mInsc-LGN interaction is vital for stabilization of LGN and for intracellular localization of mInsc.
Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.
Doe et al., Eugene, United States. In J Cell Biol, 2011
The Canoe-Pins(TPR) interaction recruits Canoe to the cell cortex and is required for activation of the Pins(TPR)-Mud (nuclear mitotic apparatus in mammals) spindle orientation pathway
aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.
van den Heuvel et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and acts downstream of the conserved PAR-3-PAR-6-aPKC polarity complex.
Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells.
Doe et al., Eugene, United States. In Cell, 2009
Study identified a previously unrecognized evolutionarily conserved Pins domain (Pins(LINKER)) that requires Aurora-A phosphorylation to recruit Dlg and promote partial spindle orientation.
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
van den Heuvel et al., Utrecht, Netherlands. In Nat Cell Biol, 2009
Spindle positioning is controlled by an evolutionarily conserved pathway, which involves LIN-5/GPR-1/2/Galpha in Caenorhabditis elegans, Mud/Pins/Galpha in Drosophila and NuMA/LGN/Galpha in humans.
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts.
Doe et al., Eugene, United States. In Nat Cell Biol, 2006
In Drosophila, neuroblasts align their spindle with a cortical Partner of Inscuteable (Pins)-G alpha i crescent to divide asymmetrically, but the link between cortical polarity and the mitotic spindle is poorly understood.
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization.
Matsuzaki et al., Kōbe, Japan. In Nat Cell Biol, 2006
Receptor-independent G-protein signalling involving the GoLoco protein Pins is essential for spindle orientation in both cell types.
Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein.
Schatten et al., Beijing, China. In Front Biosci, 2005
NuMA's function in spindle microtubule organization is regulated by RanGTP and Pins-related protein LGN.
Analysis of the roles of Pins and heterotrimeric G proteins in asymmetric division of Drosophila neuroblasts.
Yu, Singapore, Singapore. In Methods Enzymol, 2003
The role of Pins and heterotrimeric GTP-binding proteins in neuroblast asymmetric division was analyzed.
Return of the GDI: the GoLoco motif in cell division.
Siderovski et al., Chapel Hill, United States. In Annu Rev Biochem, 2003
The GoLoco motif is present as an independent element within multidomain signaling regulators, such as Loco, RGS12, RGS14, and Rap1GAP, as well as in tandem arrays in proteins, such as AGS3, G18, LGN, Pcp-2/L7, and Partner of Inscuteable (Pins/Rapsynoid).
The GoLoco motif: heralding a new tango between G protein signaling and cell division.
Siderovski et al., Chapel Hill, United States. In Mol Interv, 2002
Proteins with Galpha-binding GoLoco motifs, such as Drosophila melanogaster Pins (for Partner of Inscuteable) and its mammalian counterpart LGN, participate in multi-protein complexes that maintain cellular asymmetry and orderly segregation of chromosomal content and daughter cell bodies.
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