GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
PTEN induced putative kinase 1
PINK1, PARK6, PTEN-induced putative kinase 1
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
PINK1
antibodies
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Supplier
In International Journal of Biological Sciences, 2009
... PINK1 RNAi transgenic mice have been characterized ...
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.
Supplier
In PLoS Biology, 2005
... YFP-Parkin, YFP-Parkin mutants, mCherry-Parkin, PINK1-YFP, PINK1KD-YFP, PINK1 Δ1-110-YFP, and Opa3-PINK1 Δ1-110-YFP are in C1 or N1 Clontech vectors ...
Papers on
PINK1
PINK1 rendered temperature sensitive by disease-associated and engineered mutations.
New
Cambridge, United Kingdom. In Hum Mol Genet, 03 Apr 2013
Mutations in Parkin or PINK1 are the most common cause of recessively inherited parkinsonism.
The genetic landscape of high-risk neuroblastoma.
New
Impact
Cambridge, United States. In Nat Genet, 31 Mar 2013
Rare, potentially pathogenic germline variants were significantly enriched in ALK, CHEK2, PINK1 and BARD1.
A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling.
New
Helsinki, Finland. In Neurobiol Dis, 27 Mar 2013
The PTEN induced putative kinase 1 (PINK1) gene is mutated in patients with hereditary early onset Parkinson's disease (PD).
PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.
New
Kyoto, Japan. In Hum Mol Genet, 27 Mar 2013
The recessively inherited familial PD genes PARK2 and PARK6 have been attributed to mutations in the Parkin and PTEN-induced kinase 1 (PINK1) genes, respectively.
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations.
New
Lund, Sweden. In Parkinsonism Relat Disord, 22 Mar 2013
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism.
Tom70 Is Essential for PINK1 Import into Mitochondria.
New
Tübingen, Germany. In Plos One, Dec 2012
PTEN induced kinase 1 (PINK1) is a serine/threonine kinase in the outer membrane of mitochondria (OMM), and known as a responsible gene of Parkinson's disease (PD).
The search for genetic mouse models of prodromal Parkinson's disease.
Review
New
McLean, United States. In Exp Neurol, Oct 2012
Here we discuss the recent finding of prodromal behavioral disturbances in a PINK1 deficient mouse that manifest prior to dopaminergic cell death and correlate to 5-HT fiber losses and mitochondrial morphological changes.
Cellular reprogramming: a new approach to modelling Parkinson's disease.
Review
New
Oxford, United Kingdom. In Biochem Soc Trans, Oct 2012
In the case of PD (Parkinson's disease), reprogramming is advancing rapidly, and cell lines have been generated from patients carrying mutations in several disease-associated genes, including SNCA (α-synuclein), PARK2 (parkin), PINK1 (phosphatase and tensin homologue deleted on chromosome 10-induced putative kinase 1), PARK7 (DJ-1) and LRRK2 (leucine-rich repeat kinase 2), as well as idiopathic cases.
The genetics and neuropathology of Parkinson's disease.
Review
New
London, United Kingdom. In Acta Neuropathol, Sep 2012
We then discuss the identification of mutations in PARK2, PARK7, PINK1, ATP13A2, FBXO7, PANK2 and PLA2G6 genes.
Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders.
Review
New
Amsterdam, Netherlands. In Free Radic Biol Med, Sep 2012
The involvement of parkin, PINK1, and DJ1 in mitochondrial dysfunction, oxidative injury, and impaired functioning of the ubiquitin-proteasome system (UPS) has been intensively investigated in light of Parkinson's disease (PD) pathogenesis.
Kinases and kinase signaling pathways: potential therapeutic targets in Parkinson's disease.
Review
New
Shanghai, China. In Prog Neurobiol, Aug 2012
Causative and risk gene products associated with PD include protein kinases (such as PINK1, LRRK2 and GAK) and proteins related phosphorylation signaling pathways (such as SNCA, DJ-1).
Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.
New
Impact
Leuven, Belgium. In Science, Jul 2012
We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function.
Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients.
GeneRIF
São Paulo, Brazil. In Eur J Endocrinol, 2012
DLGAP5-PINK1 and BUB1B-PINK1 were strong predictors of disease-free survival and overall survival, respectively, among adult patients with ACT.
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.
Impact
GeneRIF
Boston, United States. In Cell, 2011
Study shows that both PINK1 and Parkin halt mitochondrial movement; PINK1 phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin- and proteasome-dependent pathway.
PINK1 and Parkin flag Miro to direct mitochondrial traffic.
Impact
Bethesda, United States. In Cell, 2011
The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy.
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
GeneRIF
Beijing, China. In Neurochem Int, 2011
downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2
What genetics tells us about the causes and mechanisms of Parkinson's disease.
Review
Impact
Paris, France. In Physiol Rev, 2011
An impressive set of data in different model systems strongly suggest that mitochondrial dysfunction plays a central role in clinically similar, early-onset autosomal recessive PD forms caused by parkin and PINK1, and possibly DJ-1 gene mutations.
Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission.
GeneRIF
New York City, United States. In Proc Natl Acad Sci U S A, 2011
Results suggest a unique pathogenic mechanism of PINK1 PD that the loss of PINK1 impairs mitochondrial fission, which causes defective assembly of the ETC complexes, leading to abnormal bioenergetics.
Variation in the PTEN-induced putative kinase 1 gene associated with the increase risk of type 2 diabetes in northern Chinese.
GeneRIF
Tianjin, China. In J Genet, 2011
association study revealed a significant association between Asn521Thr variation in PINK1 gene and type 2 diabetes suggesting that PINK1 gene Thr521 allele carriers have significantly increased susceptibility to type 2 diabetes
