Mitochondrial quality control in neurodegenerative diseases.
Strasbourg, France. In Biochimie, Sep 2013
UNLABELLED: Mutations causing genetic forms of Parkinson's disease or hereditary neuropathies have been recently shown to affect key molecular players involved in the recycling of defective mitochondria, most notably PARKIN, PINK1, Mitofusin 2 or dynein heavy chain.
Lysosomal impairment in Parkinson's disease.
Bordeaux, France. In Mov Disord, Jun 2013
Furthermore, other PD-related genes, such as leucine-rich repeat kinase-2 (LRRK2), parkin, and phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), have been mechanistically linked to alterations in ALPs.