Lysosomal impairment in Parkinson's disease.
Bordeaux, France. In Mov Disord, Jun 2013
Furthermore, other PD-related genes, such as leucine-rich repeat kinase-2 (LRRK2), parkin, and phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1), have been mechanistically linked to alterations in ALPs.
Function and characteristics of PINK1 in mitochondria.
Nara, Japan. In Oxid Med Cell Longev, 2012
Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson's disease, a neurodegenerative disorder linked to mitochondrial dysfunction.