Genetic perspective on the role of the Autophagy-Lysosome Pathway in Parkinson disease.
Montréal, Canada. In Autophagy, 24 Aug 2015
Interestingly, many of these genetic factors, such as LRRK2, GBA, SMPD1, SNCA, PARK2, PINK1, PARK7, SCARB2 and others, are involved in the autophagy-lysosome pathway (ALP).
Mechanism of phospho-ubiquitin-induced PARKIN activation.
Cambridge, United Kingdom. In Nature, 10 Aug 2015
UNASSIGNED: The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy.
How mitochondrial dynamism orchestrates mitophagy.
Beersheba, Israel. In Circ Res, 22 Jun 2015
Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway.
Quantifying ubiquitin signaling.
Boston, United States. In Mol Cell, 21 Jun 2015
Here, we review how quantitative proteomic tools and enrichment strategies are being used to quantify UB-dependent signaling systems, and to integrate UB signaling with regulatory phosphorylation events, illustrated with the PINK1/PARKIN pathway.
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.
San Francisco, United States. In Nature, Jul 2014
Here we report that USP30, a deubiquitinase localized to mitochondria, antagonizes mitophagy driven by the ubiquitin ligase parkin (also known as PARK2) and protein kinase PINK1, which are encoded by two genes associated with Parkinson's disease.