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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Pin1, DOD
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: PIN, CAN, ACID, TRF1, CIs
Papers using Pin1 antibodies
Expression profile of PAPSS2 (3′-phosphoadenosine 5′-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo
Supplier
Mueller Jonathan W. et al., In The Journal of Biological Chemistry, 2006
... par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical research ...
Papers on Pin1
Increased sucrose accumulation regulates iron-deficiency responses by promoting auxin signaling in Arabidopsis plants.
New
Zheng et al., Hangzhou, China. In Plant Physiol, Jan 2016
However, exogenous sucrose failed to increase FCR activity and expression of Fe-acquisition-related genes in the auxin transport-impaired mutants aux1-7 and pin1-1, as well as in the wild type plants treated with an auxin transport inhibitor, under Fe-deficiency.
PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population.
New
Li et al., Nanning, China. In Tumour Biol, Jan 2016
UNASSIGNED: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) plays a critical role in different signaling pathways, cell cycle progression and proliferation, and gene expression, and it has been found to overexpress in many tumor tissues.
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.
New
Surh et al., Seoul, South Korea. In Plos One, Dec 2015
Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently isomerization of the phosphorylated bonds.
The volatile 6-pentyl-2H-pyran-2-one from Trichoderma atroviride regulates Arabidopsis thaliana root morphogenesis via auxin signaling and ETHYLENE INSENSITIVE 2 functioning.
New
López-Bucio et al., Nicolás Romero, Mexico. In New Phytol, Dec 2015
Using microscopy and confocal imaging, the effects of 6-PP on root morphogenesis were found to be correlated with DR5:GFP, DR5:VENUS, H2B::GFP, PIN1::PIN1::GFP, PIN2::PIN2::GFP, PIN3::PIN3::GFP and PIN7::PIN7::GFP gene expression.
The role of pre-symbiotic auxin signaling in ectendomycorrhiza formation between the desert truffle Terfezia boudieri and Helianthemum sessiliflorum.
New
Sitrit et al., Beersheba, Israel. In Mycorrhiza, Dec 2015
Auxin also induced expression of Arabidopsis carriers AUX1 and PIN1, both of which are involved in the gravitropic response.
Pin1 liberates the human immunodeficiency virus type-1 (HIV-1): Must we stop it?
Review
New
Zhang et al., Xi'an, China. In Gene, Aug 2015
To our knowledge, this is the first review focusing on the vital role of Pin1 in the infection of HIV-1 and the development of AIDS.
Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation.
New
Impact
Weitzman et al., Paris, France. In Nature, May 2015
We used comparative genomics to identify a homologue of the peptidyl-prolyl isomerase PIN1 in T. annulata (TaPIN1) that is secreted into the host cell and modulates oncogenic signalling pathways.
Does the sequence of pulmonary vasculature ligation have any oncological impact during an anatomical lung resection for non-small-cell lung cancer?
Review
New
Veres et al., Athens, Greece. In Interact Cardiovasc Thorac Surg, Feb 2015
Another study reported no correlation between circulating pin1 mRNA levels in peripheral blood after the completion of the resection and the sequence of ligation of pulmonary vessels (9.95 ± 0.91 vs 14.71 ± 1.64, P > 0.05).
Peptidyl-Prolyl cis/trans Isomerase NIMA-Interacting 1 as a Therapeutic Target in Hepatocellular Carcinoma.
Review
Choi et al., In Biol Pharm Bull, 2014
The recent identification and characterization of the enzyme peptidyl-prolyl cis/trans isomerase never in mitosis A (NIMA)-interacting 1 (PIN1) has led to the discovery of a new mechanism regulating phosphorylation in cell signaling.
What determines a leaf's shape?
Review
Pareek et al., New Delhi, India. In Evodevo, 2013
We found that the underlying factors governing these processes are inherently genetic: PIN1 and KNOX1 are indicators of leaf initiation, HD-ZIPIII, KANADI, and YABBY specify leaf outgrowth while ANGUSTIFOLIA3 and GROWTH-REGULATING FACTOR5 control leaf expansion and maturation; besides, recent research has identified new players such as APUM23, known to specify leaf polarity.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Impact
Lu et al., Houston, United States. In Nat Cell Biol, 2012
Phosphorylated PKM2 Ser 37 recruits PIN1 for cis-trans isomerization of PKM2, which promotes PKM2 binding to importin α5 and translocating to the nucleus.
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
GeneRIF
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
Pin1 enhances the transcriptional activity of all three NR4A nuclear receptors and increases protein stability of Nur77 through inhibition of its ubiquitination.
Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle.
GeneRIF
Hanes et al., Albany, United States. In Mol Cell Biol, 2012
ESS1 associates with the phospho-Ser5 form of the RNA polymerase II (pol II) in vivo, is present along the entire length of coding genes, and is critical for regulating the phosphorylation of Ser7 within the pol II carboxy-terminal domain.
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis.
GeneRIF
Xu et al., Lyon, France. In Development, 2012
COP1 mediates the coordination of root and shoot growth by light through modulation of PIN1- and PIN2-dependent auxin transport in Arabidopsis
Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.
GeneRIF
Lu et al., Boston, United States. In Mol Cell Biol, 2012
Pin1 is a regulator of neural progenitor cell differentiation by acting on beta-catenin and provides a new postphosphorylation signaling mechanism to regulate developmental stage-specific functioning of beta-catenin signaling in neuronal differentiation.
Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.
GeneRIF
Malter et al., Madison, United States. In J Biol Chem, 2012
Results indicate that peptidyl-prolyl isomerase Pin1 Associates with Smad3 and Smad6.
Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors.
Impact
Jürgens et al., Tübingen, Germany. In Nat Cell Biol, 2012
When expressed from the same promoter, GNL2 (in contrast to the early-secretory ARF GEF GNL1) is able to replace GNOM in polar recycling of the auxin efflux regulator PIN1 from endosomes to the basal plasma membrane in non-tip growing cells.
A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta.
Impact
Tsiantis et al., Oxford, United Kingdom. In Nat Genet, 2008
Class I KNOTTED1-like homeobox (KNOX) proteins also promote leaflet initiation in C. hirsuta, and here we provide evidence that this action of KNOX proteins is contingent on the ability to organize auxin maxima via the PINFORMED1 (PIN1) auxin efflux transporter.
The retromer protein VPS29 links cell polarity and organ initiation in plants.
Impact
Gaude et al., Lyon, France. In Cell, 2007
Auxin acts locally as a morphogen and is directionally transported from cell to cell by polarized auxin efflux carriers, termed PIN-FORMED (PIN) proteins.
Combat TBI: History, Epidemiology, and Injury Modes()
Review
DePalma, Boca Raton, United States. In Unknown Journal, 0001
This chapter uses numbers available from public sources for the Department of Defense (DOD) and updated data through 2013 from the tracking tool used by the Department of Veterans Affairs (VA).
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