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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dynein, light chain, LC8-type 1

PIN, inhibitor of neuronal nitric oxide synthase
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Pin1, Pins, V1a, HAD
Papers using PIN antibodies
EnsMart: a generic system for fast and flexible access to biological data.
Supplier
Blagosklonny Mikhail, In PLoS ONE, 2003
... Samples (PIN prostates and prostate tumors) were collected from transgenic mice (CR2-TAg) expressing simian ...
Papers on PIN
WCOACH: Protein complex prediction in weighted PPI networks.
New
Jamali et al., In Genes Genet Syst, Feb 2016
The new method, WCOACH, is compared to the COACH, ClusterOne, IPCA, CORE, OH-PIN, HC-PIN and MCODE methods on several PPI networks such as DIP, Krogan, Gavin 2002 and MIPS.
Cobalt-Catalyzed Benzylic Borylation: Enabling Polyborylation and Functionalization of Remote, Unactivated C(sp(3))-H Bonds.
New
Chirik et al., Princeton, United States. In J Am Chem Soc, Feb 2016
UNASSIGNED: Cobalt dialkyl and bis(carboxylate) complexes bearing α-diimine ligands have been synthesized and demonstrated as active for the C(sp(3))-H borylation of a range of substituted alkyl arenes using B2Pin2 (Pin = pinacolate) as the boron source.
Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.
New
Sciamanna et al., Roma, Italy. In Oncotarget, Jan 2016
An in-depth analysis of colon and prostate tissues shows ORF2p expression in preneoplastic stages, namely transitional mucosa and prostate intraepithelial neoplasia (PIN), respectively.Our results show that L1-ORF2p is overexpressed in tumor and in preneoplastic colon and prostate tissues; this latter finding suggests that ORF2p could be considered as a potential early diagnostic biomarker.
Revisiting Apoplastic Auxin Signaling Mediated by AUXIN BINDING PROTEIN 1.
Review
New
Kim et al., Chinju, South Korea. In Mol Cells, Dec 2015
ROPs interact with their effectors, such as the ROP interactive CRIB motif-containing protein (RIC), to regulate the endocytosis/exocytosis of the auxin efflux carrier PIN-FORMED (PIN) proteins to mediate polar auxin transport across the PM.
Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis.
New
Fu et al., Chengdu, China. In Acta Pharm Sin B, Nov 2015
Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action.
Pavement cells: a model system for non-transcriptional auxin signalling and crosstalks.
Review
New
Yang et al., Fuzhou, China. In J Exp Bot, Aug 2015
Precise coordination of this interdigitated pattern requires auxin and an extracellular auxin sensing system that activates plasma membrane-associated Rho GTPases from plants and subsequent downstream events regulating cytoskeletal reorganization and PIN polarization.
Cellular events of strigolactone signalling and their crosstalk with auxin in roots.
Review
New
Koltai, Israel. In J Exp Bot, Aug 2015
This signalling pathway may eventually result in changes in actin-filament bundling, cellular trafficking, and PIN localization in the plasma membrane.
Strigolactone signaling in root development and phosphate starvation.
Review
Koltai et al., Israel. In Plant Signal Behav, 2014
Also, we discuss the recent findings on the non-cell autonomous signaling of SLs, that involve PIN polarization, vesicle trafficking, changes in actin architecture and dynamic in response to phosphate starvation.
A current perspective on the role of AGCVIII kinases in PIN-mediated apical hook development.
Review
Chory et al., Los Angeles, United States. In Front Plant Sci, 2014
The PIN-FORMED proteins transport auxin from cell-to-cell and control the distribution of auxin in the plant.
CLASP-mediated cortical microtubule organization guides PIN polarization axis.
Impact
Dhonukshe et al., Utrecht, Netherlands. In Nature, 2013
By localized upregulation of clathrin-dependent endocytosis at cortical microtubule- and clathrin-rich domains orthogonal to the axis of polarity, PINOID accelerates the removal of auxin transporter PIN proteins from those sites.
Annotating MYC status with 89Zr-transferrin imaging.
Impact
Lewis et al., New York City, United States. In Nat Med, 2012
Moreover, (89)Zr-transferrin imaging can detect the in situ development of prostate cancer in a transgenic MYC prostate cancer model, as well as in prostatic intraepithelial neoplasia (PIN) before histological or anatomic evidence of invasive cancer.
The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.
GeneRIF
Heierhorst et al., Melbourne, Australia. In J Exp Med, 2012
a key role for ASCIZ in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate Bim-dependent apoptosis
Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance.
GeneRIF
Zhu et al., Shanghai, China. In Cell Res, 2012
Cytosolic mfGbeta is recruited to dynein by Nudel and transported to the centrosome for rapid sequestration and degradation.
A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants.
Impact
Kleine-Vehn et al., Gent, Belgium. In Nature, 2012
We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS).
Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.
Impact
Maher et al., Birmingham, United Kingdom. In Nat Genet, 2012
DIS3L2 has a different intracellular localization and lacks the PIN domain found in DIS3 and DIS3L1; nevertheless, we show that DIS3L2 has exonuclease activity.
ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.
GeneRIF
Heierhorst et al., Australia. In J Biol Chem, 2012
The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.
The intracellular transport and secretion of calumenin-1/2 in living cells.
GeneRIF
Teng et al., Beijing, China. In Plos One, 2011
Study found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein.
LC8 dynein light chain (DYNLL1) binds to the C-terminal domain of ATM-interacting protein (ATMIN/ASCIZ) and regulates its subcellular localization.
GeneRIF
Rodriguez-Crespo et al., Budapest, Hungary. In Biochem Biophys Res Commun, 2011
these results imply a potential cellular interference between DYNLL1 and ATMIN functions.
Light-mediated polarization of the PIN3 auxin transporter for the phototropic response in Arabidopsis.
Impact
Friml et al., Gent, Belgium. In Nat Cell Biol, 2011
Our results imply that PID phosphorylation-dependent recruitment of PIN proteins into distinct trafficking pathways is a mechanism to polarize auxin fluxes in response to different environmental and endogenous cues.
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