WCOACH: Protein complex prediction in weighted PPI networks.
In Genes Genet Syst, Feb 2016
The new method, WCOACH, is compared to the COACH, ClusterOne, IPCA, CORE, OH-PIN, HC-PIN and MCODE methods on several PPI networks such as DIP, Krogan, Gavin 2002 and MIPS.
Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation.
Roma, Italy. In Oncotarget, Jan 2016
An in-depth analysis of colon and prostate tissues shows ORF2p expression in preneoplastic stages, namely transitional mucosa and prostate intraepithelial neoplasia (PIN), respectively.Our results show that L1-ORF2p is overexpressed in tumor and in preneoplastic colon and prostate tissues; this latter finding suggests that ORF2p could be considered as a potential early diagnostic biomarker.
Annotating MYC status with 89Zr-transferrin imaging.
New York City, United States. In Nat Med, 2012
Moreover, (89)Zr-transferrin imaging can detect the in situ development of prostate cancer in a transgenic MYC prostate cancer model, as well as in prostatic intraepithelial neoplasia (PIN) before histological or anatomic evidence of invasive cancer.