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Pim-2 oncogene

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: pim-1, kidney 1, HAD, CAN, AGE
Papers on PIM2
Vitamin D deficiency and length of pediatric intensive care unit stay: a prospective observational study.
Sankar et al., New Delhi, India. In Ann Intensive Care, 31 Dec 2016
On multivariable analysis, the association between length of ICU stay and vitamin D deficiency remained significant, even after adjusting for key baseline variables, diagnosis, illness severity (PIM-2), PELOD, and need for fluid boluses, ventilation, inotropes and mortality [adjusted mean difference (95 % CI): 3.5 days (0.50-6.53); p = 0.024].
Elevated PIM2 gene expression is associated with poor survival of patients with acute myeloid leukemia.
Ugorski et al., Wrocław, Poland. In Leuk Lymphoma, Feb 2016
UNASSIGNED: The PIM2 gene encodes the serine/threonine kinase involved in cell survival and apoptosis.
Red cell transfusions as an independent risk for mortality in critically ill children.
Hassan et al., Grand Rapids, United States. In J Intensive Care, Dec 2015
In this study, we examine if transfusion is an independent predictor of mortality, or if outcomes are merely a result of the initial severity as predicted by Pediatric Risk of Mortality (PRISM) III, Pediatric Index of Mortality (PIM2), and day 1 Pediatric Logistic Organ Dysfunction (PELOD) scores.
Effects of low doses of Tat-PIM2 protein against hippocampal neuronal cell survival.
Choi et al., South Korea. In J Neurol Sci, Dec 2015
Proviral Integration Moloney 2 (PIM2) proteins, one of the families of PIM kinases, play crucial roles in cell survival.
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.
Andreeff et al., Houston, United States. In Plos One, 2014
KPT-185 exhibited a p53-independent anti-lymphoma effect on MCL cells, by suppression of oncogenic mediators (e.g., XPO1, cyclin D1, c-Myc, PIM1, and Bcl-2 family members), repression of ribosomal biogenesis, and downregulation of translation/chaperone proteins (e.g., PIM2, EEF1A1, EEF2, and HSP70) that are part of the translational/transcriptional network regulated by heat shock factor 1. These results elucidate a novel mechanism in which ribosomal biogenesis appears to be a key component through which XPO1 contributes to tumor cell survival.
MYC-mediated synthetic lethality for treatment of hematological malignancies.
Huang et al., Wuhan, China. In Curr Cancer Drug Targets, 2014
SMI-induced MYC-SL can reverse eIF4F- and PIM2-induced multiple chemoresistance.
Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.
Lefevre et al., Leeds, United Kingdom. In Mol Cancer, 2014
METHODS: For these reasons, we tested the efficiency of several PIM kinase inhibitors (AZD1208, SMI4a, PIM1/2 inhibitor VI and Quercetagetin) in preventing proliferation of aggressive NHL-derived cell lines and compared their efficiency with PIM1 and/or PIM2 knockdown.
Control of Pim2 kinase stability and expression in transformed human haematopoietic cells.
Mayeux et al., Paris, France. In Biosci Rep, 2014
The oncogenic Pim2 kinase is overexpressed in several haematological malignancies, such as multiple myeloma and acute myeloid leukaemia (AML), and constitutes a strong therapeutic target candidate.
PIM kinases: an overview in tumors and recent advances in pancreatic cancer.
Zhao et al., Beijing, China. In Future Oncol, 2014
The PIM kinases represent a family of serine/threonine kinases, which is composed of three different members (PIM1, PIM2 and PIM3).
Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update.
Viswanadhan et al., Bengaluru, India. In Expert Opin Ther Pat, 2014
INTRODUCTION: The proviral insertion in murine (PIM) lymphoma proteins for which three isoforms, PIM1, PIM2 and PIM3 have been identified, belonging to the family of serine/threonine kinases has emerged recently as an important therapeutic target for the development of selective inhibitors as the new drugs for treating hematological malignancies and solid tumors.
The PIM family of serine/threonine kinases in cancer.
Carnero et al., Madrid, Spain. In Med Res Rev, 2014
The proviral insertion site in Moloney murine leukemia virus, or PIM proteins, are a family of serine/threonine kinases composed of three different isoforms (PIM1, PIM2, and PIM3) that are highly evolutionarily conserved.
Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.
Blanco-Aparicio et al., Madrid, Spain. In Front Oncol, 2013
Mouse models have also been used to study whether the inhibition of specific PIM isoforms is required to prevent carcinogen-induced sarcomas, indicating that the absence of Pim2 and Pim3 greatly reduces sarcoma growth and bone invasion; the extent of this effect is similar to that observed in the absence of all three isoforms.
RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.
Sleckman et al., Saint Louis, United States. In J Exp Med, 2012
signals from IL-7 and RAG DSBs activate distinct Pim kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.
Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.
Don et al., Ramat Gan, Israel. In Plos One, 2011
While PIM-2 can function as a potent survival factor, it can, under certain circumstances, exhibit pro-apoptotic effects as well.
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.
Wendel et al., New York City, United States. In J Exp Med, 2011
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM 1, 2 kinases in lymphoma
The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
Abe et al., Tokushima, Japan. In Leukemia, 2011
IL-6 and TNF family cytokines upregulate Pim-2 in bone marrow stromal cells and osteoclasts in multiple myeloma. This appears to be a novel anti-apoptotic mechanism for MM cell survival.
Paired box gene 5 may modulate Proviral Integration of Moloney virus 2 gene and protein expression in mature B-cells.
Ouellette et al., Moncton, Canada. In Leuk Lymphoma, 2011
Pax-5 may act as a transcription factor to modulate the expression of Pim-2 in B-cells
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.
Cyster et al., San Francisco, United States. In Immunity, 2004
In monoclonal Ig-transgenic mice, each autoantigen binding B cell receives elevated amounts of BAFF, exhibiting increased levels of NFkappaB p52 and of the prosurvival kinase Pim2.
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.
Romeyn et al., Amsterdam, Netherlands. In Nat Genet, 2002
We applied retroviral insertional mutagenesis in Myc transgenic (E mu Myc) mice lacking expression of Pim1 and Pim2 to search for genes that can substitute for Pim1 and Pim2 in lymphomagenesis.
Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.
Adams et al., Melbourne, Australia. In Cell, 1991
Three quarters contained a provirus within the known pim-1 or pim-2 loci, new loci bmi-1 and emi-1, or combinations of these.
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